Trials / Completed
CompletedNCT04395144
COVid-19: Awake Proning and High-flow Nasal Cannula in respiratorY DistrEss
Randomized-controlled Trial of HFNC Alone vs HFNC and Awake Self-proning for Treatment of Severe COVID-19
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 13 (actual)
- Sponsor
- Hôpital de Verdun · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Prone positioning is an established intervention in mechanically ventilated acute respiratory distress syndrome (ARDS) patients, with demonstrated reductions in mortality. Preliminary data suggest that awake proning in patients with COVID-19 treated with high-flow nasal oxygenation (HFNO) improves gas exchanges, and might be associated with a reduced need of mechanical ventilation, and reduced mortality. Further investigation in a formal randomized-controlled trial is need.
Conditions
- Coronavirus Infection
- COVID
- Severe Acute Respiratory Syndrome
- Respiratory Failure
- Respiratory Insufficiency
- Respiratory Distress Syndrome
- ARDS
- Lung Diseases
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Awake Prone Positioning | Patients will receive instruction to remain in prone position as long and as often as possible, up to 16h/24h |
| PROCEDURE | Standard care | Patients will not receive any special instructions with regards to proning. |
Timeline
- Start date
- 2020-05-15
- Primary completion
- 2021-03-15
- Completion
- 2021-03-15
- First posted
- 2020-05-20
- Last updated
- 2021-03-23
Locations
5 sites across 1 country: Canada
Source: ClinicalTrials.gov record NCT04395144. Inclusion in this directory is not an endorsement.