Trials / Conditions / Opioid Use Disorder

Opioid Use Disorder

649 registered clinical trials studyying Opioid Use Disorder — 181 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Dynamic Treatment Regimes for Opioid Use Disorder NCT07011758	Brigham and Women's Hospital	Phase 2
Not Yet Recruiting	Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans NCT06766331	VA Office of Research and Development	N/A
Not Yet Recruiting	Family-Focused Study to Support Medication for Opioid Use Disorder NCT07451197	University of Wisconsin, Madison	N/A
Withdrawn	Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder NCT06005662	Johns Hopkins University	Phase 2
Not Yet Recruiting	Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment NCT07024498	University of California, Davis	N/A
Not Yet Recruiting	Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine NCT07361432	VA Office of Research and Development	Phase 3
Not Yet Recruiting	Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder NCT04231708	Wayne State University	Phase 2
Not Yet Recruiting	A Bundled Intervention to End Opioid Overdoses NCT07485335	University of Alabama at Birmingham	Phase 4
Not Yet Recruiting	The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study NCT07216963	Duke University	N/A
Recruiting	A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use NCT06726200	Rachel R. Luba	EARLY_Phase 1
Not Yet Recruiting	Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Person NCT06799702	University of Georgia	N/A
Not Yet Recruiting	Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons NCT05382091	Go Medical Industries Pty Ltd	Phase 2
Not Yet Recruiting	Development of an Opioid Withdrawal Clinical Outcome Assessment NCT07094672	University of Maryland, Baltimore	—
Not Yet Recruiting	NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions i NCT06854029	Duke University	Phase 4
Not Yet Recruiting	Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to NCT07469501	University of California, San Francisco	Phase 4
Not Yet Recruiting	Sublingual Buprenorphine Through Telemedicine vs In-Person Care as Usual NCT05339256	New York State Psychiatric Institute	Phase 2
Not Yet Recruiting	Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment NCT07456930	Tools4Patient	—
Recruiting	Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine NCT07278518	Medical University of South Carolina	N/A
Not Yet Recruiting	Examining Analgesic Synergy and Efficacy in Trauma Care NCT07435077	Wake Forest University Health Sciences	Phase 4
Not Yet Recruiting	Ketones for Opioid Craving NCT07128524	University of Maryland, Baltimore	Phase 2
Not Yet Recruiting	Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial NCT07148206	Montefiore Medical Center	Phase 3
Not Yet Recruiting	Resilience Among Individuals With Opioid Use Disorder NCT06954402	Johns Hopkins University	N/A
Recruiting	Social Functioning in Opioid Use Disorder NCT07044466	Medical University of South Carolina	N/A
Suspended	Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and W NCT06577454	National Institute on Drug Abuse (NIDA)	N/A
Not Yet Recruiting	Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Inter NCT06341608	University of Pennsylvania	N/A
Not Yet Recruiting	A Clinical Trial of Telehealth Treatment for Opioid Use Disorders NCT07362082	Yale University	N/A
Not Yet Recruiting	Kentucky Women's Justice Community Overdose Innovation Network - Phase II NCT07179614	Michele Staton	N/A
Not Yet Recruiting	iSTEP-N 101b: Pharmacokinetics and Safety Study of Low- and High-Dose Naltrexone Implants vs Monthly Vivitrol NCT07064564	Akyso Therapeutics, LLC	Phase 1
Recruiting	Pilot of Mailing Buprenorphine NCT07421102	Medical University of South Carolina	EARLY_Phase 1
Not Yet Recruiting	Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic NCT07232641	Boston University	—
Recruiting	Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery NCT07115030	Yale University	N/A
Not Yet Recruiting	Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic NCT07176351	Yale University	Phase 4
Not Yet Recruiting	Methadone Patient Access to Collaborative Treatment NCT06556602	University of Arizona	N/A
Not Yet Recruiting	Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retenti NCT07439783	Alicia Bunger	N/A
Recruiting	A Study of Brenipatide in Participants With Opioid Use Disorder NCT07420283	Eli Lilly and Company	Phase 2
Not Yet Recruiting	EMS-Initiated Buprenorphine NCT07475728	Yale University	—
Not Yet Recruiting	Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study NCT07001371	Loma Linda University	N/A
Not Yet Recruiting	Transition From Acute to Chronic Opioid Use and Chronic Pain NCT07211399	Jacques E. Chelly	EARLY_Phase 1
Not Yet Recruiting	Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial NCT07439549	Pouya Azar	Phase 4
Recruiting	Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder NCT07158853	University of Minnesota	N/A
Recruiting	Ketamine for Opioid Use Disorder NCT06943859	University of Maryland, Baltimore	Phase 2
Recruiting	Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain NCT06947122	Arizona State University	N/A
Not Yet Recruiting	Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement NCT07369089	University of California, San Diego	Phase 2
Not Yet Recruiting	Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder NCT06526286	University of Colorado, Denver	—
Not Yet Recruiting	Evaluation of Clinical Decision Support in Opioid Tapering NCT06527079	University of Colorado, Denver	—
Withdrawn	Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Diso NCT06784180	University of North Carolina, Chapel Hill	Phase 4
Recruiting	HIV, Equity, and Addiction Training (HEAT) Program NCT06370481	University of Alabama at Birmingham	N/A
Recruiting	Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder NCT06651177	T. John Winhusen, PhD	Phase 2
Not Yet Recruiting	Integrating MOUD in Nonmedical Community Settings (Better Together) NCT06416020	Howard University	N/A
Recruiting	Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioi NCT07342504	University of Notre Dame	N/A
Recruiting	Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT NCT06969261	University of Pennsylvania	N/A
Not Yet Recruiting	Reentry Incentives and Support for Engagement With Contingency Management NCT07322588	Oregon Health and Science University	N/A
Withdrawn	fNIRs-based Neurofeedback to Reduce Relapse in pOUD/AUD NCT03595293	Milton S. Hershey Medical Center	N/A
Recruiting	Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioi NCT07197801	Geisinger Clinic	N/A
Recruiting	Psilocybin on Brain Mechanisms of Motivation in OUD NCT06810310	Anna Rose Childress, Ph.D.	Phase 2
Recruiting	Psilocybin for Opioid Use Disorder (OUD) NCT06796062	NYU Langone Health	Phase 2
Recruiting	Mobile Platform for Optimizing Wellness and Engagement in Recovery NCT07178990	University of Michigan	N/A
Enrolling By Invitation	Older Adults, Methadone, and Cognitive Function NCT07153029	University of Maryland, Baltimore	N/A
Not Yet Recruiting	Enhancing Recovery Capital Amid Opioid Use Disorder Pharmacotherapy: A Pilot Randomized Trial NCT05245513	Massachusetts General Hospital	N/A
Enrolling By Invitation	Evaluating the Feasibility, Acceptability, and Preliminary Outcomes of Heart Rate Variability Biofeedback for NCT07361731	Arizona State University	N/A
Recruiting	Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder NCT06872164	The City College of New York	N/A
Recruiting	Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons NCT06999811	Medical University of South Carolina	N/A
Recruiting	Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents NCT06732596	Boston Medical Center	N/A
Recruiting	NavSTAR Implementation Effectiveness Trial Across a Health System NCT07262190	Friends Research Institute, Inc.	N/A
Recruiting	Extended-release Buprenorphine as a Novel Low-dose Induction Strategy NCT06441604	Brigham and Women's Hospital	Phase 2
Recruiting	Wellcome Leap Psilocybin for OUD NCT06786325	Anna Rose Childress, Ph.D.	Phase 2
Not Yet Recruiting	PRoducing Outcome Measures for OTP Quality Improvement NCT07214389	RTI International	N/A
Not Yet Recruiting	TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) NCT07171359	Washington State University	N/A
Enrolling By Invitation	Measurement Based Care in Opioid Treatment Programs NCT06965010	University of Pittsburgh	N/A
Recruiting	The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD) NCT06832007	University of Alabama at Birmingham	N/A
Not Yet Recruiting	Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Departme NCT07129902	University of Vermont	N/A
Recruiting	Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment NCT06157840	Medical University of South Carolina	N/A
Active Not Recruiting	Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals With Co-Occurring Internalizing Dis NCT06545071	University of Minnesota	Phase 1
Recruiting	Towards Testing the Effectiveness of Recovery Community Centers (RCCs) NCT07010978	Massachusetts General Hospital	N/A
Recruiting	Autobiographical Memory in Opioid Use Disorder NCT06643988	University of Pennsylvania	N/A
Recruiting	Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD NCT06718491	Ohio State University	Phase 2
Withdrawn	Feasibility of Pediatric Emergency Department-Initiated Treatment for Adolescents With Opioid Use Disorder NCT04737603	University of California, Davis	Phase 2
Enrolling By Invitation	Mobile Mindfulness Training (mMT) for People in Medication Treatment of Opioid Use Disorder (MOUD) NCT06857968	Amy Meadows	N/A
Recruiting	CEDRN: Opioid Registry NCT07466784	University of British Columbia	—
Recruiting	Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disord NCT06642181	Rutgers, The State University of New Jersey	Phase 1
Recruiting	Buprenorphine for Individuals in Jail NCT06306443	Friends Research Institute, Inc.	Phase 3
Recruiting	Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform NCT06573476	Friends Research Institute, Inc.	N/A
Enrolling By Invitation	Impact of Collaborative Care for Pregnant Women With Opioid Use Disorder in Low-Resource Obstetric Settings NCT06956352	University of Pittsburgh	—
Recruiting	Infectious Disease (ID) Testing OUtreach in Carceral Hubs NCT06679751	Boston Medical Center	—
Recruiting	Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings NCT07169409	Boulder Care	Phase 1
Recruiting	Telehealth vs In-Person Evaluation of Addiction Treatment After Visiting the Emergency Department NCT06961058	University of California, Davis	N/A
Recruiting	Emotional Awareness and Expression Therapy for Chronic Pain and Opioid Use Disorder NCT06865560	University of Michigan	N/A
Recruiting	Semaglutide for Helping Opioid Recovery NCT06639464	Brigham and Women's Hospital	Phase 2
Recruiting	Assessing Optimal XRB Initiation Points in Jail NCT06051890	NYU Langone Health	Phase 4
Not Yet Recruiting	Injectable Buprenorphine in Prison: a Preference Trial NCT06880718	Lifespan	Phase 4
Withdrawn	A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management NCT06711640	USWM, LLC (dba US WorldMeds)	Phase 1
Active Not Recruiting	Telemedicine XR-B for Individuals in Jail NCT07524738	Friends Research Institute, Inc.	Phase 3
Recruiting	Evaluation of a Physical Device for Medical Use (ADTPM 1) for Opioid Withdrawal Symptoms NCT07079215	Nu Eyne Co., Ltd.	N/A
Recruiting	Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD) NCT06160284	Yale University	Phase 1
Recruiting	Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects NCT06981195	Virginia Commonwealth University	Phase 2
Completed	Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction NCT07344233	Icahn School of Medicine at Mount Sinai	N/A
Recruiting	Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use NCT06379984	University of Pennsylvania	Phase 2
Withdrawn	HMP for Addictions Study NCT06063499	University of Wisconsin, Madison	N/A
Recruiting	Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery NCT06949826	Jenna-Leigh Wilson	Phase 4
Recruiting	Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency NCT06872190	University of California, San Francisco	N/A
Completed	Effect of Music on Cue Reactivity for Patients With Opioid Use Disorder NCT06948890	Brigham and Women's Hospital	N/A
Recruiting	Using AI and Peer Coaching to Address Racial Disparities Among People Who Use Opioids NCT06569667	Friends Research Institute, Inc.	N/A
Completed	Adaptive Decision Support for Addiction Treatment (ADAPT) Factorial Trial NCT06793696	Yale University	N/A
Recruiting	Adaptive Decision Support for Addiction Treatment Master NCT06799117	Yale University	N/A
Recruiting	Improving Social Connectedness Through Digital Health to Enhance Recovery from OUD Among the Justice Involved NCT06896656	Rhode Island Hospital	N/A
Enrolling By Invitation	Assessing Concentrations of Methadone and Its Metabolites NCT06835582	Cari Health Inc.	—
Recruiting	Machine-Learning Prediction and Reducing Overdoses With EHR Nudges NCT06806163	University of Pittsburgh	N/A
Recruiting	Integrated Treatment for Opioid Use Disorder and PTSD NCT06641115	Medical University of South Carolina	N/A
Enrolling By Invitation	Workforce and System Change to Treat Adolescent Opioid Use Disorder Within Integrated Pediatric Primary Care NCT06477848	Indiana University	N/A
Recruiting	Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder NCT06487533	Spark Biomedical, Inc.	—
Completed	PEERS Pilot: Peer Recovery Support Program to Support Engagement in Medication for Opioid Use Disorder NCT06696066	Geisinger Clinic	N/A
Recruiting	Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention NCT06843213	University of Pennsylvania	N/A
Recruiting	A Bundled Intervention NCT06593093	University of Alabama at Birmingham	Phase 1 / Phase 2
Recruiting	Opioid Use Disorder and Pain NCT06800703	Yale University	—
Recruiting	Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD NCT06774248	Potomac Health Foundations	N/A
Recruiting	A Study to Test Whether BI 1356225 Improves Impulsive Behavior in People With Opioid Use Disorder Who Are Taki NCT06628622	Boehringer Ingelheim	Phase 1
Recruiting	Brain Training for Substance Use Disorders NCT06870110	Neurotype Inc.	N/A
Completed	Remote Methadone Ingestion Surveillance Trial (RMIST) NCT05259501	University of Texas Southwestern Medical Center	N/A
Recruiting	GLP-1R Agonist Treatment for Opioid Use Disorder NCT06548490	Milton S. Hershey Medical Center	Phase 2
Recruiting	Adversity, Brain and Opioid Use Study NCT06355778	University of Michigan	N/A
Recruiting	Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythm NCT06104280	University of Alabama at Birmingham	—
Recruiting	Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose NCT06316830	Rhode Island Hospital	Phase 2 / Phase 3
Completed	The Acupuncture for Pain, Opioid Use Disorder and Mood NCT06543355	Albert Einstein College of Medicine	N/A
Active Not Recruiting	Retention and Re-Engagement in Treatment for Addiction Following Serious Injection Related Infections (RETAIN) NCT06489535	Boston Medical Center	N/A
Recruiting	OUD (Opioid Use Disorder) Target Trial NCT06585709	Duke University	N/A
Recruiting	Remotely Observed Methadone Evaluation II NCT06338280	Sonara Health	Phase 2
Recruiting	PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study NCT05769218	Boston Medical Center	N/A
Recruiting	Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data NCT06768814	University of Washington	N/A
Recruiting	Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics NCT06624137	Yale University	—
Recruiting	Standard Versus High Dose ED-Initiated Buprenorphine Induction NCT06494904	Yale University	Phase 3
Recruiting	Low-Intensity Focused Ultrasound and the Complex Patient NCT06297200	Virginia Polytechnic Institute and State University	N/A
Not Yet Recruiting	PEX010-Assisted Therapy for Opioid Use Disorder (OUD): a Feasibility Study NCT06608459	Filament Health Corp.	Phase 2
Recruiting	EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residenc NCT06696157	Potomac Health Foundations	N/A
Recruiting	Pain Self-Management and Treatment Engagement for Patients Taking Opioids NCT06855732	University of Pittsburgh	N/A
Active Not Recruiting	E-cigarette Switching Older Adults NCT06534905	University of Maryland, Baltimore	N/A
Recruiting	Systems Analysis and Improvement to Optimize Opioid Use Disorder Care Quality and Continuity for Patients Exit NCT06593353	University of Washington	N/A
Recruiting	AvertD Post-Approval Study NCT07135323	Prescient Medicine Holdings, Inc.	—
Completed	Opioid Use and Criminal Justice: Intervening to Improve the Outcomes of Women NCT06682364	Abenaa Jones, Ph.D.	N/A
Recruiting	Adolescent Outcomes of Post-operative Opioid EXposure NCT06350409	Sharon Levy	—
Recruiting	Low-dose Buprenorphine Initiation for Opioid Use Disorder NCT05450718	Montefiore Medical Center	Phase 4
Recruiting	Combined THC and CBD for OUD and Chronic Pain NCT06544291	Yale University	Phase 2
Recruiting	Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid NCT06538558	Proniras Corporation	Phase 1
Not Yet Recruiting	The Feasibility of the OpiVenture Program for Clients Undergoing Opioid Agonist Therapy NCT06211972	Dalhousie University	N/A
Recruiting	Longitudinal Neural Fingerprinting of Opioid-use Trajectories NCT06207162	Yale University	N/A
Recruiting	Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder NCT06827288	RAND	N/A
Recruiting	Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications Fro NCT06513156	Elana Rosenthal	N/A
Not Yet Recruiting	Evaluation of Switch to Dolutegravir/Lamivudine (DTG/3TC) From Current Suppressive Antiretroviral Therapy in P NCT06580873	Saskatchewan Health Authority - Regina Area	Phase 4
Recruiting	Intervening on Opioid Use and Loneliness NCT06458335	University of Rochester	N/A
Recruiting	Cannabis and Opioid Use Disorder NCT05729932	University of Kentucky	Phase 1
Recruiting	Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction NCT06540105	University of California, San Diego	—
Completed	Philly NavSTAR Implementation Trial NCT06634277	Friends Research Institute, Inc.	N/A
Recruiting	E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder NCT05722561	NYU Langone Health	Phase 2
Completed	Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpart NCT06496230	Medical University of South Carolina	EARLY_Phase 1
Active Not Recruiting	Effective Caregiving for Neonatal Abstinence Syndrome: Testing an Instructional Mobile Technology Platform for NCT04783558	Washington State University	N/A
Completed	Assessing the Efficacy of Self-Driven Repetitive Artmaking Practice NCT06554431	Montefiore Medical Center	N/A
Recruiting	Emergency Medicine Peer Outreach Worker Engagement for Recovery NCT06320015	University of California, Los Angeles	—
Recruiting	An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT) NCT06576323	University of Pennsylvania	N/A
Active Not Recruiting	tAN for PTSD and OUD in Buprenorphine Therapy NCT06130501	University of Cincinnati	N/A
Completed	Study of the BIOPIN 6 Naltrexone Implant in Healthy Adults NCT06216132	Akyso Therapeutics, LLC	Phase 1
Active Not Recruiting	Low-dose Versus a High-dose Sublingual Buprenorphine Induction NCT05944952	Friends Research Institute, Inc.	Phase 4
Terminated	Ketamine for OUD and Suicidal Ideation in the ED NCT06111339	Brigham and Women's Hospital	Phase 2
Completed	Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnan NCT06262347	T. John Winhusen, PhD	N/A
Recruiting	Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders NCT06608979	Clemson University	N/A
Completed	Proof of Concept and Dose-ranging Study of INDV-2000 in Individuals With Moderate to Severe Opioid Use Disorde NCT06384157	Indivior Inc.	Phase 2
Recruiting	Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatme NCT06323824	Yale University	Phase 4
Completed	Oral Buprenorphine as a Novel Low-dose Induction Strategy for Opioid Use Disorder NCT06086275	Brigham and Women's Hospital	Phase 1
Recruiting	Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD NCT06288711	University of Vermont	N/A
Withdrawn	Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimu NCT06434714	Inova Health Care Services	N/A
Recruiting	Aim 2 - Conversations Can Save Lives: TALKing About Buprenorphine & Methadone for Opioid Use Treatment Initiat NCT06527820	Baystate Medical Center	N/A
Active Not Recruiting	Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment NCT06367387	Erin Winstanley	Phase 4
Recruiting	Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy NCT05985850	BC Centre on Substance Use	Phase 2
Recruiting	Disclosure Intervention for People in Treatment for Opioid Use Disorder NCT06458985	University of Delaware	N/A
Completed	Piloting a Web Resource for Pregnancy OUD in Jail NCT05853289	Johns Hopkins University	N/A
Terminated	Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmaco NCT06406400	AstraZeneca	Phase 1
Recruiting	LIFU for Treatment for Refractory Opioid Use Disorder NCT06218706	Ali Rezai	N/A
Recruiting	Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing NCT06311838	Ohio State University	N/A
Completed	STAMPS: South Carolina Buprenorphine Treatment Initiation, Adherence, and Retention Utilizing Mobile Health Un NCT06384781	Prisma Health-Upstate	N/A
Active Not Recruiting	KIOS Mobile App Evaluation NCT06212557	The University of Texas Health Science Center at San Antonio	N/A
Completed	Telehealth Treatment for Opioid Use Disorders NCT05832879	Yale University	N/A
Recruiting	Focused Ultrasound for the Complex Patient NCT06453109	Washington D.C. Veterans Affairs Medical Center	N/A
Recruiting	MBC2OTP Project (Measurement-Based Care Implementation in Community Opioid Treatment Programs) NCT06345274	Northwestern University	N/A
Recruiting	tDCS to Decrease Opioid Relapse (UH3) NCT06432465	Butler Hospital	N/A
Recruiting	MDMA for Co-occurring PTSD and OUD After Childbirth NCT05219175	University of New Mexico	Phase 2
Recruiting	Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement NCT05897788	University of Pennsylvania	N/A
Completed	The Effects of Mass Media Photographs on Drug-Related Stigma NCT06743178	Johns Hopkins Bloomberg School of Public Health	N/A
Completed	Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washi NCT06187064	University of Washington	N/A
Completed	Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System NCT06261905	Yale University	Phase 1
Completed	Women's Opioid Treatment Follow-up Study NCT05776966	Mclean Hospital	N/A
Completed	Social Networks and Methadone Maintenance Treatment Retention and Antiretroviral Therapy Retention in Tanzania NCT04479475	Johns Hopkins Bloomberg School of Public Health	N/A
Recruiting	Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 NCT05834478	Emory University	Phase 3
Enrolling By Invitation	Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder NCT06415994	Indiana University	—
Recruiting	Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder NCT06067737	Johns Hopkins University	Phase 2
Active Not Recruiting	Biopsychosocial Markers of Addiction in Opioid Users: an Integrated Approach NCT06021548	University Hospital, Strasbourg, France	—
Unknown	Assessing Dose Taken in Opioid Use Disordered Patients With an Electrochemical Sensor NCT05998876	Cari Health Inc.	—
Unknown	SafeMedWaste At-Home, Environmentally-Friendly Opioid Disposal Kit for Orthopedic Post-Operative Surgical Pati NCT06215170	SafeMedWaste, Inc.	Phase 1
Not Yet Recruiting	Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate. NCT06231849	Assiut University	—
Completed	Symptom-inhibited Fentanyl Induction NCT05905367	Pouya Azar	Phase 4
Withdrawn	Suboxone Dispenser for OUD NCT05790551	Addinex Technologies, Inc.	N/A
Recruiting	Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fen NCT06089707	Johns Hopkins University	Phase 3
Terminated	New Beginnings Following Trauma NCT05817344	Jesse McCann	N/A
Active Not Recruiting	MHealth Incentivized Adherence Plus Patient Navigation NCT06027814	University of Washington	N/A
Completed	A Stepped-Wedge Cluster Randomized Trial of a Digital App to Support Medication-Assisted Treatment in Individu NCT07140926	Bright Therapeutics	N/A
Withdrawn	Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder NCT03804619	Stanford University	N/A
Active Not Recruiting	Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering NCT05924022	Washington State University	Phase 1
Withdrawn	Psilocybin for Opioid Use Disorder in Patients on Methadone Maintenance With Ongoing Opioid Use NCT05242029	Johns Hopkins University	Phase 2
Recruiting	Translation and Validation of the COMM and ASI-SR NCT06084520	Uppsala University	—
Recruiting	Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE) NCT05790252	Washington University School of Medicine	Phase 3
Completed	Evaluating the SUBLOCADE Treatment Exit Strategy NCT05878210	Indivior Inc.	—
Recruiting	Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD NCT05817825	Brigham and Women's Hospital	N/A
Withdrawn	Assessing Optimal XR-Buprenorphine Initiation Points in Jail NCT05481112	NYU Langone Health	Phase 4
Recruiting	Integrating Brain, Neurocognitive, and Computational Tools in OUD NCT06136247	University of Pennsylvania	—
Recruiting	Using Facebook to Support Opioid Recovery Among American Indian Women NCT05995886	Mayo Clinic	N/A
Completed	Cannabidiol in the Treatment of Opioid Use Disorder NCT06206291	Yasmin Hurd	Phase 2
Completed	Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) NCT06612788	West Virginia University	N/A
Completed	Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion NCT05976646	Virginia Commonwealth University	Phase 1 / Phase 2
Completed	Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial NCT06028126	Unity Health Toronto	N/A
Active Not Recruiting	Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT NCT06021431	BehaVR LLC	N/A
Recruiting	Following Outcomes Remotely Within Addiction Recovery Domains NCT06001437	Mclean Hospital	—
Completed	SUBLOCADE Long-term Outcomes NCT05860959	Indivior Inc.	—
Recruiting	Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy NCT05942313	Ilana Hull	—
Active Not Recruiting	Continuous And Data-drivEN CarE (CADENCE) Pilot NCT05609669	University of South Florida	N/A
Completed	Mobile & Online-Based Interventions to Lessen Pain NCT05152134	Stanford University	Phase 3
Active Not Recruiting	Maternal Brain Imaging in Opioid Use Disorder NCT06008990	Indiana University	—
Suspended	Measuring Acute Drug Demand in Humans NCT05829655	University of Maryland, Baltimore	EARLY_Phase 1
Recruiting	Expanding Medication-Assisted Therapies in Central Asia NCT05579470	Yale University	N/A
Active Not Recruiting	Therapy for People With Opioid Use Disorder NCT06008769	Philadelphia College of Osteopathic Medicine	N/A
Completed	Safety, Tolerability, and Pharmacokinetics of CSX-1004 NCT06005402	Cessation Therapeutics, Inc.	Phase 1
Recruiting	Treating Polysubstance Use Using a Novel Digital Technology NCT05766631	Friends Research Institute, Inc.	Phase 3
Recruiting	Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women NCT05547048	Yale University	Phase 4
Active Not Recruiting	Peer Recovery Support Services for Individuals in Recovery Residences on MOUD NCT05616949	Potomac Health Foundations	N/A
Completed	Single Dose Study of [14C]-IDV184001AN ([14C]-IDV184001) in Healthy Adult Male Participants NCT05974046	Indivior Inc.	Phase 1
Recruiting	Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders NCT06434818	Evon Medics LLC	Phase 2
Recruiting	Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews NCT06354465	Lifespan	—
Recruiting	Stepped Care for Patients to Optimize Whole Recovery NCT05155163	Yale University	N/A
Completed	Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance an NCT06581276	Montefiore Medical Center	N/A
Active Not Recruiting	Pain Care at Home to Amplify Function (Pain CHAMP) NCT05333341	Yale University	N/A
Terminated	Impact of Bridge™ Device to Treat Opioid Withdrawal Symptoms NCT05924945	Masimo Corporation	N/A
Recruiting	Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial NCT06565416	University of New Mexico	N/A
Completed	Tai Chi Easy for Opioid Use Disorder, Anxiety, and Chronic Pain NCT05850533	Asana Recovery	N/A
Completed	Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study NCT05447286	Yale University	Phase 1
Completed	Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD) NCT05776823	University of Arkansas	N/A
Active Not Recruiting	Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial NCT05571917	University of New Mexico	N/A
Active Not Recruiting	Contingency Management for Drug Use: Does Age Matter? NCT05521854	Wake Forest University Health Sciences	N/A
Active Not Recruiting	Personalization of Opioid Prescription Following Orthognathic Surgery NCT05708521	Nova Scotia Health Authority	Phase 4
Recruiting	Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder NCT05011266	New York State Psychiatric Institute	Phase 2 / Phase 3
Completed	Auricular Acupressure as a Non-Opioid Adjuvant in Opioid Tolerant Patients NCT05711537	Wake Forest University Health Sciences	N/A
Completed	Pre-exposure Prophylaxis (PrEP) Rapid Access NCT05528562	Boston Medical Center	N/A
Withdrawn	Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use NCT04181515	Wayne State University	Phase 2
Recruiting	High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED) NCT05589181	Rutgers, The State University of New Jersey	Phase 3
Completed	Enhancing Prospective Thinking in Early Recovery (PARK) NCT05908097	Indiana University	EARLY_Phase 1
Active Not Recruiting	Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD NCT05944133	Kaiser Permanente	—
Recruiting	STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancrea NCT05603702	Indiana University	Phase 1
Recruiting	OMAR Opioid Use Disorder NCT05683184	Yale University	Phase 1
Completed	Natural Language Processing for Screening Opioid Misuse NCT05745480	University of Wisconsin, Madison	—
Completed	Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Recept NCT05547542	Cerevel Therapeutics, LLC	Phase 1
Recruiting	Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP NCT05669534	University of Connecticut	Phase 4
Completed	Evaluation of Buprenorphine Extended-Release Subcutaneous Injection at Alternative Injection Locations NCT05704543	Indivior Inc.	Phase 4
Terminated	Behavioral Effects of Drugs Inpatient 44 Neurobehavioral Mechanisms of Opioid Choice NCT06312657	Joshua A. Lile, Ph.D.	EARLY_Phase 1
Active Not Recruiting	Sublingual Dexmedetomidine for Treating Opioid Withdrawal NCT05712707	New York State Psychiatric Institute	Phase 1 / Phase 2
Recruiting	IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs NCT05492825	Albert Einstein College of Medicine	N/A
Recruiting	Divided or Single Exposure (DOSE) Study NCT05459402	University of Maryland, Baltimore	Phase 2 / Phase 3
Recruiting	Postpartum Intervention for Mothers With Opioid Use Disorders NCT05614661	Stony Brook University	N/A
Active Not Recruiting	Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; NCT05688410	Case Western Reserve University	N/A
Completed	Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot NCT05546749	Albert Einstein College of Medicine	N/A
Terminated	Novel Induction to Buprenorphine/Naloxone NCT05644587	Bicycle Health	Phase 4
Completed	A Study of SPG Block for Opioid Withdrawal NCT04946656	New York State Psychiatric Institute	N/A
Recruiting	Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment NCT05039554	Albert Einstein College of Medicine	N/A
Terminated	Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1 NCT04480554	University of Pennsylvania	Phase 2
Active Not Recruiting	Buprenorphine Integration Research and Community Health NCT05668780	Yale University	N/A
Unknown	A Multi-site Intervention to Expand Hospital Based OUD Treatment Provision NCT06291090	University of Colorado, Denver	N/A
Recruiting	Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation NCT05733442	Washington State University	N/A
Recruiting	Neuroplasticity in Maternal Opioid Use Disorder (OUD) NCT05495984	Yale University	N/A
Completed	Night Respite for Postpartum Mothers With SUD NCT05746507	Massachusetts General Hospital	N/A
Recruiting	Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine) NCT05610072	William Stoops	EARLY_Phase 1
Active Not Recruiting	Evaluating Buspirone to Treat Opioid Withdrawal NCT05511909	Johns Hopkins University	Phase 2
Completed	Suvorexant for Opioid/Stimulant Co-use NCT05546515	Johns Hopkins University	Phase 2
Completed	Clinical Outcomes Following Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention: A Long-te NCT05591703	Spark Biomedical, Inc.	—
Terminated	Reward-based Technology to Improve OUD Treatment NCT05180669	Q2i, LLC	N/A
Completed	Feasibility Study of Novel Prescription Digital Therapeutic Supporting Unobserved Buprenorphine Initiation & A NCT05412966	Pear Therapeutics, Inc.	N/A
Completed	Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Op NCT05325788	Yale University	N/A
Completed	Endocannabinoids, Stress, Craving And Pain Effects Study NCT05480072	Brigham and Women's Hospital	EARLY_Phase 1
Recruiting	Adjunctive Bright Light Therapy for Opioid Use Disorder NCT05459922	Arizona State University	N/A
Recruiting	Community-based Education, Navigation, and Support Intervention for Military Veterans NCT05343169	New York University	N/A
Completed	The Feasibility of VR for OUD NCT06255119	3D Therapy, LLC	N/A
Unknown	Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose NCT04815590	BC Centre on Substance Use	—
Terminated	Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization NCT05118204	Montefiore Medical Center	Phase 4
Completed	Remotely Observed Methadone Evaluation NCT06200740	Sonara Health	N/A
Active Not Recruiting	Multi-System Analysis of Opioid Receptor Binding NCT05528848	University of Pennsylvania	Phase 1
Completed	Assessment of Methadone and Buprenorphine in Interstitial Fluid NCT05546229	Cari Health Inc.	—
Completed	A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users. NCT05587998	AstraZeneca	Phase 1
Completed	Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses NCT04634279	RAND	N/A
Completed	Implementing a Pharmacist-Integrated Collaborative Model of Medication Treatment for Opioid Use Disorder NCT05310786	Trustees of Dartmouth College	N/A
Completed	Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Op NCT04976855	Indivior Inc.	Phase 1
Unknown	Investigation of the Relationship Between Different Assesments in Individuals in Opioid Maintenance Treatment NCT05635682	Gazi University	—
Completed	Cariprazine for Comorbid Cocaine and Opioid Use Disorder NCT05063201	Kyle Kampman	Phase 2
Withdrawn	Olanzapine in OUD Patients NCT05179772	University of Pennsylvania	Phase 2
Completed	Computer Based Treatment for Cognitive Behavioral Therapy and Cooperative Pain Education and Self-Management NCT05204576	Yale University	N/A
Unknown	Evaluating the Pharmacokinetics and Patient Outcomes of Buprenorphine Microdosing NCT05307458	United Health Services Hospitals, Inc.	—
Terminated	Epigenetic Biomarker for Opioid Use Disorder NCT05419986	University Hospital, Strasbourg, France	N/A
Completed	Pharmacokinetic and Safety Study of Naltrexone Release From Subcutaneous BICX104 Pellets Compared to Vivitrol NCT04828694	BioCorRx Inc	Phase 1

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