NCT06355778

Adversity, Brain and Opioid Use Study

A Mechanistic Investigation of Risk Factors for Opioid Use Disorder: Examining Hippocampal-based Context-dependent Learning and Memory Associated With Adverse Childhood Experiences

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 185 (estimated)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.

Conditions

• Opioid Use Disorder
• Healthy

Interventions

Type	Name	Description
OTHER	Magnetic Resonance Imaging (MRI)	Enrolled participants will have one MRI during the study on day 2 after having Day 1 visit. During the MRI the participants will complete various tasks.
BEHAVIORAL	Computer Tasks	Eligible participants will complete computer tasks (cognitive tasks, spatial navigation tasks, context dependent fear learning, etc.) at visit 1 and then during the MRI.

Timeline

• Start date: 2025-01-09
• Primary completion: 2028-04-01
• Completion: 2028-04-01
• First posted: 2024-04-09
• Last updated: 2025-12-12

Locations

1 site across 1 country: United States