NCT07128524

Ketones for Opioid Craving

Ketone Supplementation for Opioid Craving and Withdrawal

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) undergoing in-patient acute withdrawal management. The main questions it aims to answer are: * Does KS reduce craving for opioids in patients with opioid use disorder? * Does KS reduce symptoms of opioid withdrawal such as low mood and pain? Researchers will compare KS to a placebo to see if KS works to reduce craving for opioids and reduce withdrawal symptoms in adults entering in-patient acute withdrawal management for opioid use disorder. Participants will: * Be given KS or a placebo three (3) times daily for seven (7) days * Complete mood, pain tolerance, and subjective opioid withdrawal assessments

Conditions

• Opioid Use Disorder

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Treatment with Ketone Supplement	Participants (n=25) will receive three doses of a ketone supplement drink daily for seven days.
DIETARY_SUPPLEMENT	Treatment with Placebo	Participants (n=25) will receive three doses of a placebo drink for seven days.

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-08-31
• Completion: 2027-09-01
• First posted: 2025-08-19
• Last updated: 2026-03-13

Locations

1 site across 1 country: United States