| Withdrawn | A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management Opioid Withdrawal (Disorder), Opioid Use Disorder | Phase 1 | 2025-06-01 |
| Completed | A Study Evaluating the Relative Bioavailability of Lofexidine Granules for Reconstitution Compared to LUCEMYRA Normal Healthy Volunteers | Phase 1 | 2021-02-16 |
| Active Not Recruiting | Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Neoplasms | Phase 2 | 2019-12-31 |
| Terminated | Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Withdrawal (Disorder) | Phase 2 | 2019-08-02 |
| Completed | Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Substance Withdrawal Syndrome, Opiate Addiction, Opiate Dependence | Phase 1 | 2016-06-01 |
| Completed | Lofexidine Pharmacokinetics in the Presence of Paroxetine in Healthy Volunteers Healthy | Phase 1 | 2016-01-01 |
| Completed | Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy Subjects Healthy | Phase 1 | 2015-05-01 |
| Completed | Open-Label, Safety Study of Lofexidine Opioid Withdrawal | Phase 3 | 2015-02-01 |
| Completed | Single-dose Pharmacokinetics and Safety of Oral Lofexidine in Renally-Impaired Subjects Renally Impaired Subjects | Phase 1 | 2014-11-01 |
| Completed | Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects Liver Failure | Phase 1 | 2014-06-01 |
| Completed | Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdr Opioid Dependence, Acute Opioid Withdrawal Syndrome | Phase 3 | 2013-06-01 |
| Completed | Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Pati Opioid Dependence, Buprenorphine Withdrawal Syndrome | Phase 1 | 2013-03-01 |
| Completed | Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients Opioid Dependence, Methadone Withdrawal Syndrome | Phase 1 | 2012-07-01 |
| Completed | Lofexidine Mass Balance in Volunteers Normal Healthy Volunteers | Phase 1 | 2012-05-01 |
| Completed | Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients Opioid Dependence, Methadone Withdrawal Syndrome | Phase 1 | 2012-02-01 |
| Completed | Lofexidine Food Effect Study in Healthy Volunteers Healthy | Phase 1 | 2011-10-01 |
| Completed | Lofexidine ADME & Mass Balance in Volunteers Normal Healthy Volunteers Will be Treated With Lofexidine to Understand the Absolute Bioavailability and Mass Balance Recovery of the Product | Phase 1 | 2011-07-01 |