NCT06954402

Resilience Among Individuals With Opioid Use Disorder

A Novel Human Laboratory Model of Resilience Among Individuals With Opioid Use Disorder

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 125 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.

Detailed description

This study is an outpatient, within-subject, randomized controlled trial designed to develop and validate a novel laboratory-based model for assessing resilience in individuals with opioid use disorder (OUD). The study employs a dual-condition design where participants complete two experimental sessions administered in a randomized order: one under a stress condition and under a non-stress condition. In each session, participants will perform a series of standardized laboratory tasks aimed at evaluating cognitive, emotional, and control aspects of resilience. Objective measures (e.g., task performance data and physiological indices) and subjective ratings of stress reactivity will be collected to capture both behavioral and self-perceived responses.

Conditions

• Opioid Use Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Acute Stress Intervention (MAST-based)	This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.
BEHAVIORAL	Non-Stress Intervention (NST-based)	In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.

Timeline

• Start date: 2026-04-30
• Primary completion: 2029-04-30
• Completion: 2029-04-30
• First posted: 2025-05-01
• Last updated: 2026-01-07

Locations

1 site across 1 country: United States