| Not Yet Recruiting | Intratesticular Artery Resistive Index Changes After Varicocelectomy NCT07517952 | Assiut University | N/A |
| Recruiting | Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential NCT07456397 | Fecundis Lab SL | — |
| Recruiting | Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress NCT07375238 | Ginefiv | N/A |
| Not Yet Recruiting | Warfarin Effects on Male Fertility After Cardiac Surgery NCT07330869 | Città di Lecce Hospital, GVM Care & Research | — |
| Not Yet Recruiting | Royal Jelly Supplementation in Unexplained Male Infertility NCT07337265 | Medipol University | N/A |
| Active Not Recruiting | To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized NCT07369362 | MotilityCount aps | N/A |
| Active Not Recruiting | Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men NCT07402759 | South Valley University | Phase 3 |
| Completed | Identifying Candidates for Limited Dissection at Microdissection TESE. NCT07286279 | Clinique Ovo | — |
| Not Yet Recruiting | Effect of Graminex on Infertility Related to Male Accessory Glands Inflammation NCT06974175 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Withdrawn | A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0 NCT02839447 | Aytu BioPharma, Inc. | — |
| Recruiting | The Efficiency of a New Sperm-Wash Device for Intrauterine Insemination in Couples With Infertility NCT06956287 | Chung Shan Medical University | N/A |
| Recruiting | Male Infertility and Assisted Reproductive Technologies Research Biobank NCT06880302 | Reproductive Medicine Associates of New Jersey | — |
| Recruiting | Efficacy and Safety of a New Sperm Capacitation Method NCT06742437 | Fecundis Lab SL | — |
| Not Yet Recruiting | Supplementation for Male Subfertility NCT06091969 | Hamilton Health Sciences Corporation | Phase 2 |
| Enrolling By Invitation | Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome NCT07523022 | Szeged University | Phase 4 |
| Recruiting | Live Birth Rate Between ICSI and AOA and ICSI Alone in Patients With Severe Teratospermia NCT06561451 | ShangHai Ji Ai Genetics & IVF Institute | N/A |
| Active Not Recruiting | Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA) NCT06566599 | Inception Fertility Research Institute, LLC | — |
| Completed | Can the Origin of Sperm Affect Embryo Ploidy in Patients With Severe Male Factor Infertility? NCT06476379 | Ganin Fertility Center | N/A |
| Enrolling By Invitation | Biobank Aimed to Study Gynecological Pathologies, of Male and Female Infertility and Pregnancy Pathologies NCT07265908 | IRCCS San Raffaele | — |
| Active Not Recruiting | Trial to Improve Fertilization Rate and Embryo Development in Intracytoplasmic Sperm Injection (ICSI) Cycles NCT07056400 | Ain Shams University | N/A |
| Recruiting | Study to Verify the Efficacy of a Product Containing 125 mg of TetraSOD® for the Treatment of Male Infertility NCT06324071 | Fitoplancton Marino, S.L. | N/A |
| Active Not Recruiting | Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Mal NCT06100432 | Duta Wacana Christian University | Phase 4 |
| Completed | Home Semen Analysis Tests As a Screening Tool for Fertility Patients NCT06188936 | University of Aberdeen | EARLY_Phase 1 |
| Completed | Identifying Molecular Determinants of Infertility in Men (MODIFY) NCT06147700 | Institute for Human Development and Potential (IHDP), Singapore | — |
| Recruiting | Probiotics on Sperm Quality in Male Infertility Patients NCT07345455 | Mackay Memorial Hospital | N/A |
| Completed | Human Papilloma Virus In Male Infertility NCT07121530 | South Valley University | — |
| Unknown | Oxidative Stress and Male Infertility. NCT06210568 | IRCCS San Raffaele | — |
| Unknown | Personalized Signature of Chronic Inflammation and Early Aging Predictive of the Comorbidities in Infertile Me NCT06082362 | IRCCS San Raffaele | — |
| Not Yet Recruiting | Relationship of the Microenvironment and Male Fertility NCT04704141 | University of Illinois at Chicago | — |
| Unknown | Efficacy and Safety of Linggui Yangyuan Paste in Patients With Male Infertility NCT05792813 | Xiyuan Hospital of China Academy of Chinese Medical Sciences | EARLY_Phase 1 |
| Completed | Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF NCT07004309 | Hanoi Medical University | N/A |
| Recruiting | Platelet Rich Plasma Testis Treatment for Infertile Men NCT05479474 | Stanford University | N/A |
| Unknown | Excision Versus Preservation of Spermatic Cord Lipoma Detected During Subinguinal Varicocelectomy NCT06257459 | Tanta University | N/A |
| Active Not Recruiting | SpermQT Prospective Observational Trial NCT05966883 | Inherent Biosciences | — |
| Completed | A Novel Sperm Selection Method Provides Advantages Over Conventional Approaches NCT06545318 | Center of Innovation Technology & Reproductive Medicine | N/A |
| Completed | Home Semen Testing in Men Beginning Attempts to Conceive NCT05503862 | Northwestern University | N/A |
| Unknown | Characterization of Sperm Population Following Different Selection Procedures NCT05383599 | Universitair Ziekenhuis Brussel | — |
| Completed | Management of Non Obstructive Azoospermia in Men NCT06983626 | South Valley University | N/A |
| Unknown | Expanding Fertility Care to Poor and Low Resourced Settings Study NCT05205733 | University of California, San Francisco | N/A |
| Unknown | CMV IGG Antibodies in Semen as a Predictor for Blood Testis Barrier Damage NCT05302856 | Hadassah Medical Organization | N/A |
| Completed | Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters NCT05616598 | Benha University | Phase 2 / Phase 3 |
| Active Not Recruiting | The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled NCT05290558 | KK Women's and Children's Hospital | Phase 2 |
| Unknown | Use of Testicular Spermatozoa in Non-azoospermic Patients NCT05203211 | Istituto Clinico Humanitas | — |
| Unknown | Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infe NCT05200663 | Sharif Medical Research Center | Phase 2 |
| Recruiting | Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragme NCT04959864 | GYNOV | N/A |
| Unknown | The Impact of Sinopharm COVID-19 Vaccination on Male Fertility NCT04946565 | Cairo University | — |
| Completed | The Effectiveness of Spermotrend Food Supplement in the Treatment of Male Infertility NCT05222841 | Catalysis SL | Phase 2 / Phase 3 |
| Completed | Spermatozoa Morphology Selection by Thermotaxis NCT04849156 | Instituto Valenciano de Infertilidade de Lisboa | — |
| Completed | Investigation of The Effectiveness of Antioxidant Therapy in Oligoasthenoteratozoospermic Infertile Men NCT06042738 | Ondokuz Mayıs University | N/A |
| Completed | Effect of Antioxidant Probiotic Administration on Seminal Quality and Reproductive Outcomes. NCT04585984 | Fundación IVI | N/A |
| Unknown | "System Medicine" Approach for Prevention Strategies for Comorbidities in Infertile Men NCT06183255 | IRCCS San Raffaele | — |
| Unknown | Vitamin D Level vs Semen Parameters NCT03167008 | Assiut University | — |
| Unknown | Validation of New Devices Against Ambient Electromagnetic Radiation NCT04541459 | Waveguard GmbH | EARLY_Phase 1 |
| Completed | Strategies for Reducing Sperm DNA Fragmentation in ICSI Semen Samples: a Prospective Randomized Controlled Tri NCT04496232 | Ganin Fertility Center | N/A |
| Completed | Human Sperm Epigenetics in Embryonic Development. NCT04256668 | University Hospital, Basel, Switzerland | N/A |
| Completed | Administration of Antioxidants to Infertile Men and Sperm Quality NCT04256278 | Aristotle University Of Thessaloniki | N/A |
| Unknown | Epigenetic and Genetic Effects in Cancer Patients: Analysis Pre and After Treatment NCT04200118 | IVI Barcelona | — |
| Unknown | The Impact of Lifestyle on Sperm Telomere Length and Telomerase Activity in Men Undergoing IVF Treatments NCT04158765 | Hillel Yaffe Medical Center | — |
| Completed | The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor NCT03960229 | Bezmialem Vakif University | N/A |
| Completed | Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine NCT03802864 | Weill Medical College of Cornell University | Phase 4 |
| Unknown | To Evaluate the Effect of Reveratrol,Folic Acid, Vitamin D, Vitamin B12 and B6 in Male Infertility NCT03864198 | University Of Perugia | N/A |
| Unknown | Myo-inositol and an Antioxidant Mix for the Treatment of Vietnamese Infertile Men NCT03726450 | Andrology and Fertility Hospital of Hanoi | N/A |
| Completed | Tobacco and Sperm Genome: Effects of Smoking Cessation NCT03552081 | University Hospital, Toulouse | N/A |
| Completed | Andrositol® TEST as Diagnostic Assay to Predict the Fertilization Potential in IVF NCT03677011 | Lo.Li.Pharma s.r.l | N/A |
| Completed | Effect of Two Doses of Coenzyme Q10 on Seminal Fluid and Semen Antioxidant Status NCT03850561 | University of Sumer | N/A |
| Completed | Impact of Coenzyme Q10 and Selenium on Seminal Fluid and Semen Antioxidant Status NCT03834831 | University of Sumer | N/A |
| Completed | Investigating the Physiological Effects of Weight Loss on Male Fertility NCT03553927 | Imperial College London | N/A |
| Completed | ICSI Versus Conventional IVF in Couples With Non-severe Male Infertility NCT03298633 | Jie Qiao | N/A |
| Unknown | Evaluation of Personalised Support Program Effectiveness in Sperm Quality Improvement NCT03475199 | FabLife | N/A |
| Unknown | Effect of Liver Cirrhosis on Semen Parameters and Reproductive Hormones NCT03167749 | Assiut University | — |
| Unknown | Relationship Between Nitric Oxide (NO) in Follicular Fluid and Sperm Fertilization Ability NCT03307655 | IVI Murcia | N/A |
| Completed | The Acceptance, Safety, and Efficacy of MadaJet Versus Needle Injection for Sperm Retrieval in Patients With A NCT03181243 | Vietnam National University | N/A |
| Completed | Treatment of Severe Male Infertility - Predictive Factors (Imaging) NCT02931721 | Turku University Hospital | — |
| Completed | Semen Analysis and Insight Into Male Infertility NCT04178954 | Batool Mutar | — |
| Completed | Males, Antioxidants, and Infertility Trial NCT02421887 | Yale University | Phase 2 |
| Terminated | Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Pati NCT02605070 | Instituto de Investigacion Sanitaria La Fe | Phase 3 |
| Completed | Impact of Antioxidant Treatment on DNA Fragmentation Index NCT03466229 | Region Skane | N/A |
| Recruiting | Protocol N. 2014 - Observational Study on the Quality of Life of Outpatients NCT06193850 | IRCCS San Raffaele | — |
| Completed | Body Mass Index and Age Correlate With Antioxidant Supplementation Effects on Sperm Quality NCT04177667 | University of Roma La Sapienza | N/A |
| Completed | Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation NCT02268123 | Reproductive Medicine Associates of New Jersey | — |
| Completed | RA-2 13-cis Retinoic Acid (Isotretinoin) NCT02061384 | University of Washington | Phase 2 |
| Completed | Choline Dehydrogenase and Sperm Function: Effects of Betaine NCT02122211 | University of North Carolina, Chapel Hill | Phase 1 |
| Completed | Small RNA Pathways in Mammalian Gametogenesis NCT02864329 | Weill Medical College of Cornell University | — |
| Terminated | IMSI in Couples With Previous Implantation Failures NCT02107521 | Sapientiae Institute | N/A |
| Completed | Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin Therapy NCT05110391 | ANDROFERT - Clinica de Andrologia e Reproducao Humana | — |
| Completed | Relationship Between Sperm Head Vacuoles and Sperm DNA Alterations in Infertile Men NCT02006446 | University Hospital, Rouen | — |
| Completed | Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility NCT02889341 | Vida Recoletas Sevilla | N/A |
| Completed | Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Admini NCT01880086 | Weill Medical College of Cornell University | Phase 2 |
| Completed | Metabolic Syndrome and Male Infertility NCT01974947 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | Ramipril for the Treatment of Oligospermia NCT01856361 | Weill Medical College of Cornell University | N/A |
| Completed | Effect of Sorting of Apoptotic Spermatozoa on the Outcome of Assisted Reproduction NCT02166567 | University Hospital, Basel, Switzerland | N/A |
| Completed | MSCs For Treatment of Azoospermic Patients NCT02025270 | Al-Azhar University | Phase 1 / Phase 2 |
| Completed | Swim up and Gradient Methods Used in Assisted Reproduction Techniques on DNA Fragmentation of Spermatozoa NCT01859520 | Gazi University | N/A |
| Completed | Herbal Tonic Fertile Supplement(ZO2C5) NCT01895816 | Arash Khaki | Phase 3 |
| Completed | Regulation of Stem Spermatogonia in the Mature Testis NCT02756923 | Weill Medical College of Cornell University | — |
| Completed | Endocrine Disrupting Chemicals: Potential Effects on Male and Female Reproductive Health in Saskatchewan NCT02272439 | University of Saskatchewan | — |
| Unknown | Oxidative Stress and Lipidomics in Male Infertility NCT02062229 | University of Roma La Sapienza | — |
| Completed | Impact of Folates in the Care of the Male Infertility NCT01407432 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Withdrawn | The Paleolithic Diet and Male Factor Infertility NCT01346631 | HaEmek Medical Center, Israel | N/A |
| Completed | A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers NCT01595308 | POM Wonderful LLC | Phase 1 |
| Completed | Effects of Korean Red Ginseng on Male Infertility NCT02202382 | Pusan National University Hospital | Phase 4 |
| Completed | Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controll NCT02204826 | Pusan National University Hospital | Phase 4 |
| Completed | Male Infertility Related With Post Infection Inflammatory Syndrome NCT01407484 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial NCT01304927 | Rigshospitalet, Denmark | Phase 2 / Phase 3 |
| Unknown | Proposed Research Protocol For Male Infertility NCT01255397 | HaEmek Medical Center, Israel | N/A |
| Completed | FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy NCT02349945 | Azienda USL Modena | Phase 2 / Phase 3 |
| Completed | Impact of Sperm DNA Integrity on In Vitro Cycles NCT01232465 | Northwell Health | — |
| Unknown | Is a Carnitine Based Food Supplement (PorimoreTM) for Infertile Men Superior to Folate and Zinc With Regard to NCT01075334 | Shaare Zedek Medical Center | N/A |
| Unknown | Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoosp NCT01178463 | Hillel Yaffe Medical Center | — |
| Completed | Spermotrend in the Treatment of Male Infertility NCT00975117 | Catalysis SL | Phase 3 |
| Completed | HOP-2A - Intratesticular Hormone Levels NCT00756561 | University of Washington | — |
| Completed | A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight NCT00596739 | University of Pennsylvania | — |
| Completed | Patient-Centered Implementation Trial for Single Embryo Transfer NCT00315029 | Radboud University Medical Center | N/A |
| Completed | Study of Sperm Molecular Factors Implicated in Male Fertility NCT00481403 | Instituto Valenciano de Infertilidad, IVI VALENCIA | — |
| Unknown | 'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologis NCT00119925 | Radboud University Medical Center | N/A |
| Completed | Vitamin E and Male Infertility NCT00178516 | University of Rochester | — |
| Completed | Genetic Causes of Male Infertility NCT00341120 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Completed | Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm NCT00012480 | National Institute of Environmental Health Sciences (NIEHS) | — |
| Completed | Genetic Studies Spermatogenic Failure NCT00548977 | National Cheng-Kung University Hospital | — |
| Completed | Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele NCT00044369 | National Institute of Environmental Health Sciences (NIEHS) | — |
| Terminated | Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectom NCT00961558 | Mount Sinai Hospital, Canada | N/A |