NCT04849156

Spermatozoa Morphology Selection by Thermotaxis

Sperm Selection by Thermotaxis: a Novel Technique to Enhance Assisted Reproductive Technologies' Outcomes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Instituto Valenciano de Infertilidade de Lisboa · Network
• Sex: Male
• Age: 18 Years – 39 Years
• Healthy volunteers: —

Summary

This study aims to eventually assess the usefulness of thermotaxis for sperm selection in routine clinical practice.

Detailed description

As the world's total fertility rate decline, every year more couples require assisted reproductive technologies (ART) in order to achieve their desire to become parents. However, these techniques are not guaranteed solutions and still many couples with unexplained infertility fail to conceive. One of the reasons might be the relative selection of spermatozoa for the following ART. To minimize a poor selection made by the operator and to standardize spermatozoa selection, we suggest a new method might be used in combination with the routine spermatozoa selection techniques. Thermotaxis might be used in the ART setting as a tool to select the best spermatozoa as human spermatozoa after capacitation responds positively to a temperature gradient change. Moreover, this might be the possible navigation mechanism of spermatozoa in the female genital tract. We hypothesize that spermatozoa selected by thermotaxis behavior might increase the morphologically normal spermatozoa number in the cohort used during ART. The aim of this study is to evaluate if thermotaxis is a good method for selecting morphologically normal sperm for ART.

Conditions

• Male Infertility

Interventions

Type	Name	Description
OTHER	Sperm selection by thermotaxis	Selection of healthy sperm by thermotaxis procedure

Timeline

• Start date: 2021-04-12
• Primary completion: 2022-01-05
• Completion: 2022-03-09
• First posted: 2021-04-19
• Last updated: 2022-08-04

Locations

1 site across 1 country: Portugal