Trials / Unknown
UnknownNCT06183255
"System Medicine" Approach for Prevention Strategies for Comorbidities in Infertile Men
New "System Medicine" Approach for the Development of Primary Prevention Strategies for Comorbidities in Infertile Men
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- IRCCS San Raffaele · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- —
Summary
By applying a "system medicine" approach, the project aims to identify new biomarkers and/or prognostic tools aimed at developing personalized strategies to prevent the onset of comorbidities in infertile men.
Detailed description
By applying a "system medicine" approach, the project aims to identify new biomarkers and/or prognostic tools aimed at developing personalized strategies to prevent the onset of comorbidities in infertile men. The findings will provide new insights into the relationship between male infertility and somatic health, and shed light on the role of the microbiome in modulating the activity of the immune system. A "signature" of lack of immunological tolerance and biomarkers could be useful to predict future oncologic and non-oncological comorbidities in infertile men. This will let the development of a more clinically reliable and cost-effective personalized primary/secondary prevention strategy in a population at high risk of clinically relevant diseases.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Observation and evaluation of clinical parameters in the two cohorts | During medical history evaluation, all factors that could negatively affect male fertility, like prevalent comorbidities, previous testis surgery, and any disorder affecting testicular function will be investigated in fertile and infertile men. Moreover, family history will be deeply investigated, including fertility status and prevalence of malignant Non Communicables Diseases. A comprehensive physical examination will be performed on each infertile and fertile man. |
Timeline
- Start date
- 2021-01-18
- Primary completion
- 2025-07-01
- Completion
- 2025-07-01
- First posted
- 2023-12-27
- Last updated
- 2023-12-27
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06183255. Inclusion in this directory is not an endorsement.