NCT02202382

Effects of Korean Red Ginseng on Male Infertility

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Pusan National University Hospital · Academic / Other
• Sex: Male
• Age: 25 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Objective: Several in vitro studies report positive effects of ginseng on spermatogenesis. However, no controlled human clinical study of the effect of Korean red ginseng (KRG) on spermatogenesis has been performed. This study was performed to investigate the effects of KRG on semen parameters in male infertility patients in a randomized, double-blind, placebo-controlled study. Methods: A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups: non-V + P group, placebo; V + P group, placebo and varicocelectomy; non-V + KRG group, 1.5-g KRG daily; V + KGR group, 1.5-g KRG daily and varicocelectomy. Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks.

Conditions

• Male Infertility

Interventions

Type	Name	Description
DRUG	Korean Red Ginseng, Varicocelectomy
DRUG	Placebo	Placebo were provided by Korean Ginseng Corporation (Daejeon, Korea). The placebo capsules were identical in shape, color, and taste.
PROCEDURE	Varicocelectomy	Surgical microscope-assisted varicocelectomy using the subinguinal approach was conducted by a single surgeon.

Timeline

• Start date: 2011-04-01
• Primary completion: 2012-01-01
• First posted: 2014-07-29
• Last updated: 2014-07-31

Locations

1 site across 1 country: South Korea