NCT06476379

Can the Origin of Sperm Affect Embryo Ploidy in Patients With Severe Male Factor Infertility?

Can the Origin of Sperm - Ejaculated or Testicular- Affect Embryo Ploidy in Patients With Severe Male Factor Infertility?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Ganin Fertility Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical outcomes following transfers of euploid embryos. This comparison will be conducted between cases where ejaculated sperm and cases where testicular sperm were used for intracytoplasmic sperm injection (ICSI), specifically focusing on severe male factor infertility patients.

Conditions

• Male Infertility

Interventions

Type	Name	Description
PROCEDURE	Testicular sperm extraction (TESE)	Surgical procedure used to retrieve sperm directly from the testicles of men who have low sperm production or no sperm in their ejaculate
OTHER	Ejaculate	Ejaculate processing for ICSI

Timeline

• Start date: 2024-06-25
• Primary completion: 2025-04-30
• Completion: 2025-04-30
• First posted: 2024-06-26
• Last updated: 2025-08-15

Locations

1 site across 1 country: Egypt