NCT02025270

MSCs For Treatment of Azoospermic Patients

Using of Bone Marrow Derived Mesenchymal Stem Cells For Treatment of Azoospermic Patients

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: Male
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

In this study, we performed autologous BMDMSC transplantation to the testis of Azoospermic patients in a trial to enhance and activate the spermatogonial stem cells of the testis and aiming to produce motile sperm.

Detailed description

Bone marrow aspirated and stem cells were isolated, cultured and characterized using flow cytometer. Stem cells prepared according to GMP regulations then injected into rete testis using special syringe. Patients follow up will carried out for a year , three month interval. FSH, testosterone, testicular size as well as sexual potency will assessed every three months.

Conditions

• Male Infertility

Interventions

Type	Name	Description
BIOLOGICAL	Stem Cells	60 ml of bone marrow will aspirated and used for stem cells isolation. Then stem cells will cultured using autologous serum, characterized and prepared using GMP rules and finally injected into rete testis.

Timeline

• Start date: 2012-10-15
• Primary completion: 2016-10-15
• Completion: 2022-12-20
• First posted: 2014-01-01
• Last updated: 2023-03-01

Locations

1 site across 1 country: Egypt