NCT04177667

Body Mass Index and Age Correlate With Antioxidant Supplementation Effects on Sperm Quality

Body Mass Index and Age Correlate With Antioxidant Supplementation Effects on Sperm Quality: Post-hoc Analyses From a Double-blind Placebo-controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 104 (actual)
• Sponsor: University of Roma La Sapienza · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Spermatozoa are vulnerable to lack of energy and oxidative stress as a result of elevated levels of reactive oxygen species. Therefore, it is essential that appropriate nutrients are available during maturation. This randomized, double-blind, placebo-controlled trial investigated the effect of 6 months supplementation with carnitines and other micronutrients on sperm quality in 104 subjects with oligo- and/or astheno- and/or teratozoospermia with or without varicocele. Semen analyses were done at the beginning and end of the treatment. In addition to main analyses, post-hoc analyses for age and body mass index (BMI) were carried out. Results were interpreted by dividing the population into two age and BMI classes.

Conditions

• Male Infertility

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Proxeed	Treatment with dietary supplement for male infertility for Proxeed Arm
OTHER	Placebo	Treatment with placebo for Placebo Arm

Timeline

• Start date: 2014-12-01
• Primary completion: 2015-06-30
• Completion: 2017-11-30
• First posted: 2019-11-26
• Last updated: 2019-11-26