| Not Yet Recruiting | Sodium Lactate in Severe TBI NCT06701760 | University of California, Los Angeles | Phase 2 |
| Not Yet Recruiting | Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury NCT07326059 | Healing Hope International | — |
| Not Yet Recruiting | PASTRAMI : Patient-specific Statistics for Microstructure-augmented Connectomics NCT07527949 | Rennes University Hospital | N/A |
| Not Yet Recruiting | Comparing Approaches to Helping People With Chronic Traumatic Brain Injury Manage Their Health Care NCT07483528 | Indiana University | N/A |
| Enrolling By Invitation | Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy NCT07521384 | Healing Hope International | — |
| Recruiting | Ketamine in Severe Traumatic Brain Injury NCT06062628 | University of Texas Southwestern Medical Center | EARLY_Phase 1 |
| Not Yet Recruiting | Treating Traumatic Brain Injury With Transcranial Direct Current Stimulation NCT06989970 | Johns Hopkins University | N/A |
| Not Yet Recruiting | Modulating Inflammation in Neuro-Trauma NCT07510074 | The University of Texas Health Science Center at San Antonio | N/A |
| Not Yet Recruiting | Promoting Neuroplastic Changes of Patients With TBI NCT06465290 | University of Maryland, Baltimore | N/A |
| Not Yet Recruiting | Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II NCT07287358 | Maastricht University Medical Center | N/A |
| Not Yet Recruiting | Implementation of TBI-RECOVER in Substance Use Treatment NCT07215221 | Ohio State University | N/A |
| Recruiting | Carbon Dioxide Administration and Brain Waste Clearance NCT07357090 | Andrew Mayer | N/A |
| Not Yet Recruiting | Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis NCT07492602 | Casa Colina Hospital and Centers for Healthcare | N/A |
| Recruiting | Improving Speech in Noise Using Noninvasive Stimulation NCT07176936 | University of Florida | N/A |
| Recruiting | Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: NCT07473505 | Reset Medical and Wellness Center | — |
| Recruiting | Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI NCT07351305 | The University of Texas Health Science Center at San Antonio | N/A |
| Not Yet Recruiting | TBI- Efficacy of Steroids in Acute Vasogenic Edema NCT07358312 | Meditech Foundation | — |
| Not Yet Recruiting | Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI) NCT07038889 | Indiana University | N/A |
| Not Yet Recruiting | Regional Ventilation Evaluation During Neuro-injury Weaning Study NCT07067671 | Assistance Publique - Hôpitaux de Paris | — |
| Not Yet Recruiting | Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials NCT06963775 | Ramon Diaz-Arrastia | — |
| Recruiting | A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults a NCT07455136 | Hoffmann-La Roche | — |
| Enrolling By Invitation | TRACK-TBI Precision Medicine Part 3 - Option II NCT06790095 | University of California, San Francisco | Phase 2 |
| Recruiting | Remote Stimulation and Training to Advance Recovery From TBI in Seniors NCT07332299 | Minneapolis Veterans Affairs Medical Center | N/A |
| Not Yet Recruiting | Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI) NCT07338383 | The Geneva Foundation | — |
| Recruiting | tPBM in Older Adults With Traumatic Brain Injury NCT06956404 | NYU Langone Health | N/A |
| Recruiting | Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments NCT07404761 | Motion Informatics LTD | N/A |
| Not Yet Recruiting | Protein Intake Dosage on the Prognosis of Neurocritical Patients NCT07295301 | Wenshan City People's Hospital | N/A |
| Not Yet Recruiting | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for TBI NCT05018832 | The Foundation for Orthopaedics and Regenerative Medicine | Phase 1 |
| Not Yet Recruiting | Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic NCT07271524 | Friedhelm Hummel | N/A |
| Recruiting | Reliability and Validity of the PReFS NCT07280923 | Baylor University | — |
| Recruiting | Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Inv NCT07230002 | Pôle Saint Hélier | N/A |
| Terminated | Cervical Transcutaneous SCS for TBI NCT07147816 | Roberto de Freitas | N/A |
| Recruiting | Hypnosis and Attention in Patients With a Neurological Disease (Stroke, Traumatic Brain Injury and Multiple Sc NCT07256704 | Luzerner Kantonsspital | N/A |
| Recruiting | Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures NCT07225101 | University of Michigan | Phase 4 |
| Not Yet Recruiting | Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model NCT06193382 | University of Miami | N/A |
| Completed | Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and With NCT07406555 | Universitas Jenderal Soedirman | Phase 4 |
| Recruiting | Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAI NCT07237386 | University Hospital, Ghent | N/A |
| Recruiting | Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury NCT06848140 | Beth Israel Deaconess Medical Center | N/A |
| Not Yet Recruiting | Methylprednisolone for Moderate to Severe Traumatic Brain Injury NCT07180277 | Zhangjiagang First People's Hospital | Phase 4 |
| Not Yet Recruiting | Clinical Feasibility & Validation of the Augmented Reality GlenxRose Acquired Brain Injury Rehabilitation Prog NCT05897593 | University of Alberta | N/A |
| Not Yet Recruiting | Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect NCT07017140 | University of Vic - Central University of Catalonia | N/A |
| Not Yet Recruiting | Diagnosis of Intracranial Hypertension Using TCCD, ONSD and ODH by Bedside Ultrasound NCT07151287 | Xiangya Hospital of Central South University | — |
| Not Yet Recruiting | Neuromodulation and FMRI in Neurodegenerative Diseases Study NCT06873750 | Sunnybrook Health Sciences Centre | N/A |
| Not Yet Recruiting | Spinal Stimulation and Gait Training to Improve Mobility in TBI NCT06886152 | Kessler Foundation | N/A |
| Not Yet Recruiting | An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI) NCT07120373 | University of Nottingham | — |
| Recruiting | Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents NCT07267819 | Uniformed Services University of the Health Sciences | — |
| Recruiting | NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury NCT06584591 | Kessler Foundation | N/A |
| Active Not Recruiting | Feasibility and Outcomes of 3D-printed External Cranial Orthosis After Craniectomy NCT07122752 | Tan Tock Seng Hospital | — |
| Recruiting | Visual Plasticity Following Brain Lesions NCT07105358 | Georgetown University | N/A |
| Recruiting | A Study to Evaluate the SENSE Device's Ability to Detect TBI NCT06828107 | Sense Diagnostics, LLC | — |
| Recruiting | An Gong Niuhuang Wan Promotes the Postoperative Neurological Function Recovery of Patients With Traumatic Brai NCT07074938 | Huaqiu Zhang | N/A |
| Recruiting | Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans NCT06217575 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Comparison of Haloperidol and Dexmedetomidine for Delirium and Agitation in ICU Patients With Traumatic Brain NCT06993194 | Benha University | N/A |
| Active Not Recruiting | Metaverse Applications in Clinical Neurorehabiliation: Device Feasibility NCT07456475 | Istituto per la Ricerca e l'Innovazione Biomedica | N/A |
| Completed | Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Br NCT07244822 | Universitas Jenderal Soedirman | N/A |
| Recruiting | Effect of Semi-elemental Enteral Nutrition on Gastrointestinal Tolerance in Patients With Traumatic Brain Inju NCT07092423 | Tang-Du Hospital | N/A |
| Recruiting | Crainio Non-invasive ICP Monitor for TBI NCT06453733 | Crainio Ltda | N/A |
| Recruiting | Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Bala NCT06893029 | Dominik Straumann | N/A |
| Recruiting | TBI Rehabilitation and Activation in Veterans NCT06562127 | Northern California Institute of Research and Education | N/A |
| Recruiting | Neural Mechanism of Cerebrocardiac Syndrome Following Traumatic Brain Injury NCT06958406 | Shanghai 6th People's Hospital | — |
| Not Yet Recruiting | Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury NCT06927063 | Turku University Hospital | — |
| Recruiting | Improving Sleep in Veterans With the Polytrauma Clinical Triad NCT06477796 | VA Office of Research and Development | N/A |
| Recruiting | Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide NCT06866691 | Wake Forest University Health Sciences | Phase 4 |
| Enrolling By Invitation | Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury NCT05616910 | University of Pennsylvania | Phase 2 |
| Recruiting | Assessment of Noninvasive Neuromodulation in a Group of Traumatic Brain Injured Patients and Healthy Volunteer NCT07373366 | University of Sao Paulo | Phase 2 |
| Active Not Recruiting | Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Pr NCT06884319 | Benha University | — |
| Not Yet Recruiting | AI-driven Personalized Exercise Feedback Program on Exercise Adherence in Traumatic Brain Injury NCT06817564 | National Defense Medical Center, Taiwan | N/A |
| Not Yet Recruiting | Validation Study of Simplified Chinese Version of LOTCA Scale in the Assessment of Cognitive Impairment in Pat NCT06850584 | Nanjing Broad Biopharmaceutical Ltd. | — |
| Not Yet Recruiting | An Observational Exploration of Clinical Trials Targeting Traumatic Brain Injury NCT06264518 | Power Life Sciences Inc. | — |
| Completed | High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction NCT06945835 | University of Hartford | N/A |
| Enrolling By Invitation | Feasibility Study: The Contribution of Hypnosis in the Management of Adults With Brain Injuries NCT06817837 | Centre Hospitalier Universitaire de Liege | N/A |
| Recruiting | Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patient NCT07413562 | Beijing Tiantan Hospital | N/A |
| Not Yet Recruiting | Expanding Access to mTBI Treatment for Veterans and Service Members With Co-occurring Substance Use NCT06620900 | Shepherd Center, Atlanta GA | N/A |
| Enrolling By Invitation | Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instruc NCT05917665 | University of Southern California | — |
| Recruiting | Evaluation of the Abbott i-STAT TBI Biomarker Test NCT06766435 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | The Safety and the Efficiency of Hyperbaric Oxygen in Traumatic Brain Injury NCT06816199 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Not Yet Recruiting | The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study NCT06726135 | ThomasCorbett | — |
| Recruiting | Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention NCT06073106 | Tan Tock Seng Hospital | — |
| Not Yet Recruiting | Therapeutic Normothermia in TBI NCT06540768 | London Health Sciences Centre | N/A |
| Recruiting | Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing Wit NCT06782464 | Centre National de Rééducation Fonctionnelle et de Réadaptation | N/A |
| Active Not Recruiting | 3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hem NCT06780436 | The Geneva Foundation | — |
| Not Yet Recruiting | Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion NCT06718608 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | Treating Word Finding Difficulties in Traumatic Brain Injury With HD-tDCS NCT06840808 | The University of Texas at Dallas | N/A |
| Recruiting | Personalized Cognitive Integrated Motor Training Using Virtual Reality to Improve Gait and Balance NCT06473987 | Kessler Foundation | N/A |
| Not Yet Recruiting | Role of Electrocardiogram Abnormalities in Prediction of Mortality in Patients With Isolated Traumatic Brain I NCT06701279 | Assiut University | — |
| Recruiting | CoMind Early Feasibility Study NCT06368648 | CoMind Technologies Limited | — |
| Recruiting | Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics NCT06697808 | Wake Forest University Health Sciences | — |
| Recruiting | Prismatic Adaptation in Cognitive Rehabilitation NCT06920784 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Recruiting | Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation NCT06544408 | Florida State University | N/A |
| Recruiting | Rapid MRI for Assessing Functional Abilities and Predicting TBI Outcomes NCT06454591 | D.J Cook | — |
| Recruiting | Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care NCT06241482 | Shanghai 6th People's Hospital | N/A |
| Completed | Transcranial Doppler in Traumatic Brain Edema NCT07107997 | Alexandria University | — |
| Recruiting | Development and Implementation of an Intervention Enhancing Involvement of Relatives to Patients With Acquired NCT06796335 | Rigshospitalet, Denmark | — |
| Not Yet Recruiting | Effects of Dexmedetomidine on Agitation in Critically Ill TBI Patients NCT06620393 | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | Phase 2 / Phase 3 |
| Recruiting | Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (Bo NCT06293300 | University of Miami | Phase 2 |
| Recruiting | Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury NCT06581003 | University of South Florida | Phase 3 |
| Not Yet Recruiting | Tbit System Precision and Correlation of Different Blood Samples NCT04478812 | BioDirection Inc | N/A |
| Enrolling By Invitation | Improving In-hospital and Post-discharge Patient Education for Mild Traumatic Brain Injury NCT06595914 | Medical College of Wisconsin | N/A |
| Recruiting | Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation NCT06589362 | Shirley Ryan AbilityLab | N/A |
| Suspended | Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans NCT05671692 | Christine Marx, MD | Phase 2 |
| Recruiting | Acute EpiDural Hematoma Treated With Middle Meningeal Artery Embolization: a Randomized Trial (AEDH-MT) NCT06292585 | Changhai Hospital | N/A |
| Completed | Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury NCT06520358 | University of Florida | N/A |
| Recruiting | The Relationship Between Obesity and Chronic Headache NCT06445595 | Karaman Training and Research Hospital | — |
| Recruiting | Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI NCT06429774 | Beijing Tiantan Hospital | — |
| Enrolling By Invitation | Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury NCT05826912 | University of California, San Francisco | Phase 2 |
| Not Yet Recruiting | Pilot Study of Whole Blood Transfusion for Trauma Brain Injury (TBI) NCT06184828 | Oregon Health and Science University | Phase 3 |
| Recruiting | The REACH Intervention for Caregivers of Veterans and Service Members With TBI NCT06111794 | University of Virginia | N/A |
| Recruiting | Sildenafil for Microvasculopathy in Chronic TBI NCT05782244 | University of Pennsylvania | Phase 2 |
| Not Yet Recruiting | Intensive Physical Exercise Versus Standard Exercise During Rehabilitation of Patients With Traumatic Brain In NCT06431139 | Christian Riberholt | N/A |
| Recruiting | Effects of Intravascular Administration of Mesenchymal Stromal Cells Derived from Wharton's Jelly of the Umbil NCT06146062 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Recruiting | Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients NCT06311604 | University Hospital, Grenoble | N/A |
| Not Yet Recruiting | Study on the Efficacy of Long-term Drainage of Subdural Effusion After Decompressive Craniectomy NCT06391203 | RenJi Hospital | N/A |
| Active Not Recruiting | Machine Learning to Predict Factors Affecting Rehabilitation Length of Stay and Healthcare Costs for Neurologi NCT06704997 | Tan Tock Seng Hospital | — |
| Active Not Recruiting | Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients Wi NCT06253923 | SHINKEI Therapeutics, Inc | Phase 2 |
| Unknown | Multiomic Analysis of Serum in Acute Period of Traumatic Brain Injury NCT05867992 | RenJi Hospital | — |
| Recruiting | Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury NCT06282965 | University of Arizona | Phase 1 / Phase 2 |
| Recruiting | Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App NCT06494319 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Interve NCT06276894 | Craig Hospital | N/A |
| Recruiting | CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms NCT05663034 | Johns Hopkins University | N/A |
| Active Not Recruiting | Telerehabilitation Early After CNS Injury NCT06069999 | TRCare, Inc. | N/A |
| Unknown | Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients NCT06319638 | Copka Sonpashan | N/A |
| Recruiting | Ventilatory Parameters in Acute Neurological Injury NCT06192342 | Ramos Mejía Hospital | — |
| Recruiting | Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model NCT06188364 | Virginia Commonwealth University | EARLY_Phase 1 |
| Recruiting | Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions NCT05885529 | Centre Hospitalier Princesse Grace | — |
| Recruiting | Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury NCT05951777 | Hope Biosciences LLC | Phase 2 |
| Recruiting | MENTOR Wellness Program NCT06148324 | NYU Langone Health | N/A |
| Completed | Walking After Traumatic Brain Injury in Older Adults NCT06222502 | Timothy Morris | N/A |
| Completed | Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury NCT06375421 | Vanderbilt University Medical Center | N/A |
| Completed | Intermittent Oro-esophageal Tube Feeding in Traumatic Brain Injury Patients NCT06328985 | Copka Sonpashan | N/A |
| Recruiting | Evaluating the Effect of Tranexamic Acid on the Clinical Outcomes in Patients With Traumatic Brain Injury NCT06330935 | Mansoura University | Phase 1 / Phase 2 |
| Recruiting | Brain Balance Study NCT05714150 | VA Office of Research and Development | N/A |
| Unknown | Effect of Lidocaine Block in Traumatic Brain Injury NCT06304116 | Muhammad | N/A |
| Withdrawn | Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old NCT04766944 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Unknown | Impact of v Release on Dysphagia in Patients With Traumatic Brain Injury NCT06328309 | Copka Sonpashan | N/A |
| Not Yet Recruiting | Ketamine Treatment for PTSD and MDD in TBI NCT06228391 | Minneapolis Veterans Affairs Medical Center | Phase 2 |
| Unknown | Effect of Myofascial Release on Dysphagia in Patients With Traumatic Brain Injury NCT06256861 | Zeng Changhao | N/A |
| Unknown | Different Feeding in Traumatic Brain Injury Patients NCT06249022 | Zeng Changhao | N/A |
| Withdrawn | Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patient NCT06261281 | Zeng Changhao | N/A |
| Recruiting | Metabolomic Profiling of Patients With Traumatic Brain Injury NCT07292766 | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | — |
| Withdrawn | Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients NCT06228170 | Zeng Changhao | N/A |
| Enrolling By Invitation | BETTER (Brain Injury Education, Training, and Therapy to Enhance Recovery) NCT05929833 | Duke University | N/A |
| Recruiting | TMS-fNIRS Personalized Dosing NCT05916417 | Florida State University | N/A |
| Recruiting | Virtual Reality in Rehabilitation of Executive Functions in Children With Mild or Moderate Traumatic Brain Inj NCT06127459 | Merja Nikula | N/A |
| Unknown | "Cognitive Rehabilitation With Direct Current Transcranial Stimulation in Post-Traumatic Brain Injury Patients NCT06228872 | Mutual de Seguridad Hospital Clinico | N/A |
| Completed | Beyond One Option for the Treatment of Severe Traumatic Brain Injury NCT06787040 | Meditech Foundation | — |
| Recruiting | Robotic Balance Training to Improve Postural Control and Balance Post-Traumatic Brain Injury NCT06184295 | Kessler Foundation | N/A |
| Recruiting | Connectivity and Neural Signatures of Consciousness in Unresponsive States NCT06426615 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Terminated | Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury NCT05970575 | Neurological Associates of West Los Angeles | Phase 2 |
| Recruiting | GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI NCT06028334 | Albert Einstein Healthcare Network | N/A |
| Recruiting | Investigation on the Cortical Communication System NCT06207591 | UMC Utrecht | N/A |
| Unknown | Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Br NCT06096415 | Abalonex, LLC | Phase 2 |
| Completed | Blended Reality Immersion for Geriatric Head Trauma: The BRIGHT Study NCT06074328 | University of Maryland, Baltimore | N/A |
| Recruiting | Cognitive and Vascular Functioning Following TBI NCT06034509 | Walter Reed National Military Medical Center | — |
| Active Not Recruiting | Narrative Discourse Treatment Development NCT05008419 | VA Office of Research and Development | N/A |
| Recruiting | Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions NCT06065046 | Tang-Du Hospital | Phase 2 |
| Completed | Feasibility of a Motor-cognitive Training Program in Patients With Traumatic Brain Injury NCT06149975 | Swiss Federal Institute of Technology | N/A |
| Recruiting | Effect of Graded Aerobic Exercise in Mild Traumatic Brain Injury NCT06177509 | Sunnaas Rehabilitation Hospital | N/A |
| Recruiting | Intracranial PrEssure Time dOse (ImPETO) NCT04459806 | University of Milano Bicocca | — |
| Unknown | Assessment of the Feasibility of a Systematic Multidimensional Evaluation of the Outcome of Traumatic Brain In NCT06194071 | Nantes University Hospital | — |
| Unknown | Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Ge NCT06072001 | Apurano Pharmaceuticals GmbH | Phase 3 |
| Unknown | Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis NCT06071949 | Apurano Pharmaceuticals GmbH | Phase 3 |
| Completed | The Effect of Mannitol Volume with Changes in Osmolarity in Traumatic Brain Injury NCT06846307 | Universitas Diponegoro | Phase 3 |
| Active Not Recruiting | Brain Stimulation for Concussion NCT05889117 | The Mind Research Network | N/A |
| Recruiting | Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury NCT06103201 | University of Maryland, Baltimore | Phase 1 |
| Recruiting | Eye Recovery Automation for Post Injury Dysfunction (iRAPID) NCT06105892 | New Jersey Institute of Technology | N/A |
| Unknown | ICP Threshold After Decompressive Craniectomy NCT06083792 | Tang-Du Hospital | — |
| Unknown | A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score NCT06036732 | Istanbul University - Cerrahpasa | — |
| Recruiting | The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury NCT05095857 | Rigshospitalet, Denmark | Phase 4 |
| Completed | A Pilot Randomized Controlled Trial: CoINTEGRATE NCT05732285 | University of Michigan | N/A |
| Completed | Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the IC NCT06052787 | Ain Shams University | Phase 3 |
| Unknown | Neutral Versus Liberal fLuId In Traumatic Brain Injury: a Randomised Controlled Trial NCT05983549 | Universita degli Studi di Genova | N/A |
| Completed | Repeatability Assessment of Neurovisual Tasks for the Construction of a New Concussion Monitoring Tool (SPORTI NCT05992194 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Enrolling By Invitation | Hybrid Approach to Pediatric Rehabilitation NCT06547762 | Alyn Pediatric & Adolescent Rehabilitation Hospital | N/A |
| Recruiting | Evaluation of Consciousness Impairment in Severe TBI and Full-cycle Neuroregulation Based on Multimodal Imagin NCT06469827 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Completed | Exploring Accessible Beauty for Individuals With Upper Extremity Deficits NCT05945784 | Casa Colina Hospital and Centers for Healthcare | — |
| Recruiting | Community-based Implementation of Online EmReg NCT05933629 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort NCT05855876 | Stella Center | — |
| Recruiting | Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research NCT04806620 | Brain Inflammation Collaborative | — |
| Active Not Recruiting | Cerebral Oxygenation and Metabolism and Severe Head Injury in Paediatrics (COMetSHIP) NCT05717647 | Cambridge University Hospitals NHS Foundation Trust | — |
| Active Not Recruiting | Improving Grasp Function in People With Sensorimotor Impairments by Combining Electrical Stimulation With a Ro NCT05976087 | Andrea Cimolato | N/A |
| Completed | Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Dee NCT06067750 | Nottingham University Hospitals NHS Trust | — |
| Unknown | Assistive Soft Skills and Employment Training (ASSET) in TBI Injury NCT05705817 | Kessler Foundation | N/A |
| Recruiting | MUSic Therapy In Complex Specialist Neurorehabilitation NCT05777499 | University College, London | N/A |
| Active Not Recruiting | Expanding Delivery of an Evidence-based Weight-loss Intervention to Enhance Access and Reach Underserved Group NCT05699772 | Baylor Research Institute | N/A |
| Recruiting | Evaluation of the SCALED (SCaling AcceptabLE cDs) NCT05628207 | University of Minnesota | — |
| Recruiting | Continuous Passive Motion Versus Heterotopic Ossification NCT05906056 | University of Ioannina | N/A |
| Suspended | Virtual Reality Treadmill Training in Individuals With Traumatic Brain Injury NCT05721209 | NYU Langone Health | N/A |
| Recruiting | Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury NCT05716048 | Kessler Foundation | Phase 1 |
| Unknown | TeleRehab to Restore Upper Limb Function in People With Chronic TBI NCT06184932 | Kessler Foundation | N/A |
| Active Not Recruiting | Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI NCT05671874 | University of Massachusetts, Worcester | N/A |
| Recruiting | High Intensity Step Training After Traumatic Brain Injury NCT05702138 | Craig Hospital | Phase 2 |
| Active Not Recruiting | Intervention to Change Affect Recognition and Empathy NCT05636020 | Indiana University | N/A |
| Recruiting | The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children NCT07090057 | University of Alberta | N/A |
| Recruiting | Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries NCT05819008 | Umeå University | — |
| Recruiting | Predict Severe Traumatic Brain Injury NCT06966713 | University of Chicago | — |
| Unknown | Heart Rate Variability Biofeedback Following Traumatic Brain Injury NCT05913505 | Brigham Young University | EARLY_Phase 1 |
| Recruiting | Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery NCT05622461 | Children's Hospital Medical Center, Cincinnati | N/A |
| Completed | Pilot Trial for Adults With Acquired Brain Injury NCT05793827 | Colorado State University | N/A |
| Enrolling By Invitation | Impact of Pre-Military Life Experiences/Exposures on Active-Duty Service Members' Psychological Health NCT06070025 | University of Southern California | — |
| Completed | Investigating CBF and ICP Using DCS NCT06039098 | Queen Mary University of London | — |
| Unknown | Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness NCT06283901 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin NCT04932096 | Oregon Health and Science University | Phase 2 |
| Completed | Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries NCT07493889 | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | N/A |
| Completed | Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-H NCT05408975 | The University of Texas at Dallas | N/A |
| Completed | m-Health Supportive Care Transition Program in Improving Post-Discharged Outcomes NCT05951335 | Prince of Songkla University | N/A |
| Recruiting | Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT) NCT05337618 | University of Cincinnati | Phase 2 |
| Recruiting | Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control NCT07056361 | Jorge Gonzalez-Martinez | N/A |
| Unknown | Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Pe NCT05048966 | Kessler Foundation | N/A |
| Terminated | Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain In NCT05464277 | Evangelismos Hospital | N/A |
| Unknown | Role of Combined Therapy of Propranolol and Gabapentin in Paroxysmal Sympathetic Hyperactivity in Traumatic Br NCT05427474 | Zagazig University | Phase 3 |
| Completed | Video Review of the Frequency and Assessment of Head Impacts During the FIFA World Cup 2022TM NCT05629169 | Federation Internationale de Football Association | — |
| Terminated | Effect of High-Intensity Gait Training Using a Treadmill on Locomotion Recovery in Traumatic Brain Injury Pati NCT05622786 | Carilion Clinic | N/A |
| Unknown | Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could it Make a Dif NCT05551871 | Assiut University | N/A |
| Unknown | VIrtual Reality in Cognitive Rehabilitation of Processing Speed for Persons With ABI NCT05443542 | Sunnaas Rehabilitation Hospital | N/A |
| Unknown | The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System NCT05503316 | University Hospital, Ghent | N/A |
| Recruiting | Clinical and Molecular Biological Data Collection and Analysis in Patients With TBI NCT05533060 | Shanghai 6th People's Hospital | — |
| Terminated | Post-Brain Injury Walking and Balance Recovery Program NCT05934773 | The University of Texas Medical Branch, Galveston | N/A |
| Recruiting | Effects of Nurse-Guided BBTi for Improving Insomnia : in Patients at the Recovery Following Traumatic Brain In NCT05402761 | Taipei Medical University | N/A |
| Unknown | Blood Biomarkers to Improve Management of Children With Traumatic Brain Injury NCT05413499 | Nantes University Hospital | N/A |
| Unknown | Purpose in Life Survey NCT05790278 | Mary Radomski | — |
| Active Not Recruiting | Neuropsychological Rehabilitation Over the Internet NCT05413733 | Helsinki University Central Hospital | N/A |
| Unknown | Cortical Excitability in Post-traumatic Epilepsy NCT05517954 | Mid-Atlantic Epilepsy and Sleep Center, LLC | — |
| Withdrawn | TMS-EEG for Cortical Excitability NCT05472363 | Mayo Clinic | N/A |
| Recruiting | University of Colorado - Restoring Efficient Sleep After TBI NCT05683145 | VA Eastern Colorado Health Care System | N/A |
| Recruiting | Neuroplasticity After Proprioceptive Rehabiliation NCT05277519 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Unknown | Efficacy of Lung and Inferior Vena Cava Sonography for Fluid Optimization NCT05400343 | Mansoura University | N/A |
| Terminated | Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy NCT06199778 | Zeng Changhao | N/A |
| Completed | Effect of Oral Enteral Nutrition on Severe Traumatic Brain Injury NCT06304012 | Muhammad | N/A |
| Terminated | The Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheos NCT06248970 | Zeng Changhao | N/A |
| Unknown | Feasibility of tDCS as an Adjunct to Outpatient Physiotherapy in Children With ABI NCT05637957 | Holland Bloorview Kids Rehabilitation Hospital | N/A |
| Unknown | To Compare the Effect of Receiving the Technology-based Training Along With the Conventional Therapy to the Co NCT06080269 | Hamad Medical Corporation | N/A |
| Completed | Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury NCT04933448 | Gillette Children's Specialty Healthcare | N/A |
| Recruiting | Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function NCT07056348 | Jorge Gonzalez-Martinez | N/A |
| Completed | Eye Tracking Technology in the Diagnosis of Neurological Patients NCT05536921 | AssisTech Sp. z o.o. | — |
| Unknown | Usability Study of CEREBO® - A Novel Non-invasive Intracranial Bleed Detector NCT05340114 | Bioscan Research Pvt. Ltd. | N/A |
| Completed | Dry Needling Effects Post-traumatic Brain Injury NCT05460728 | Anas Radi Hassan Alashram | N/A |
| Completed | Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder NCT02990793 | Wave Neuroscience | N/A |
| Unknown | Near Infra-red Spectroscopy for Detection of Intracranial Haematoma NCT03653728 | Chinese University of Hong Kong | — |
| Completed | The Effects of Hyperbaric Oxygen on Non-acute Traumatic Brain Injury NCT05387018 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Cold-stored Platelet Early Intervention in TBI NCT04726410 | Jason Sperry | Phase 2 |
| Unknown | Cohort Study on the Effects of Aging in Acquired Brain Injury Patients NCT05499806 | University Medical Center Groningen | — |
| Recruiting | Phase I Human Analytics (HALO) Study NCT05423860 | HALO Diagnostics | — |
| Completed | Effect of Fixed vs. Tailored Intensity tDCS for Attention Deficit After TBI NCT05302362 | Seoul National University Hospital | N/A |
| Completed | Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients NCT05081063 | Loma Linda University | Phase 3 |
| Active Not Recruiting | TRACK-TBI Longitudinal Biomarker Study NCT05201833 | University of Pennsylvania | — |
| Active Not Recruiting | Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI) NCT05823766 | University of Pennsylvania | — |
| Withdrawn | Foundations in Developing Precision Cognitive Restoration NCT05117502 | VA Office of Research and Development | N/A |
| Completed | ACTIVE: Activity Therapy to Increase Veteran Engagement NCT04976621 | VA Office of Research and Development | N/A |
| Completed | Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance NCT07273864 | Li Hai | N/A |
| Terminated | Descriptive and Prospective Study of Sphincter Disorders in the Severe Traumatic Brain Injury Population NCT05163262 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Selective CT for Anticoagulated Head Injured Patients NCT05364749 | Dr. Kerstin de Wit | — |
| Unknown | Prevalence, Severity, Risk Factors, and Prognostic Value of Hyponatremia in Patients With Traumatic Brain Inju NCT05301049 | University Hospital, Montpellier | — |
| Recruiting | Longitudinal Assessment of Traumatic Microvascular Injury-2 NCT05725993 | University of Pennsylvania | — |
| Unknown | Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Br NCT05279599 | Tang-Du Hospital | — |
| Recruiting | Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury NCT05236010 | University of New Mexico | N/A |
| Enrolling By Invitation | Aerobic Exercise After Traumatic Brain Injury NCT05786729 | Centre for Neuro Skills | Phase 1 / Phase 2 |
| Unknown | Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury NCT05182619 | Sohag University | EARLY_Phase 1 |
| Completed | A Study to Test the SENSE Device in Military-Age Patients With Traumatic Brain Injury NCT05155800 | Sense Diagnostics, LLC | — |
| Recruiting | Register Study: Implementation of Pharyngeal Electrostimulation Therapy for the Treatment of Acute Neurogenic NCT05190718 | Karl Landsteiner University of Health Sciences | — |
| Unknown | Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury NCT05531383 | Minia University | N/A |
| Unknown | Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity NCT04815967 | Supernus Pharmaceuticals, Inc. | Phase 2 / Phase 3 |
| Completed | Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Bra NCT05058677 | The University of Texas Health Science Center, Houston | Phase 4 |
| Recruiting | Amygdala Memory Enhancement NCT05065450 | Washington University School of Medicine | N/A |
| Completed | "The Effect of Stellate Ganglion Block in Severe Brain Injury" NCT04208477 | University Medical Centre Ljubljana | N/A |
| Withdrawn | Importance of Substance P in Intracranial Pressure Elevation Following Traumatic Brain Injury NCT03035838 | Arun Gupta | EARLY_Phase 1 |
| Unknown | To Evaluate the Effect of Glibenclamide in Reducing Brain Edema of TBI NCT05148403 | Beijing Tiantan Hospital | Phase 1 / Phase 2 |
| Completed | Nutritional Treatment for the Amelioration of Traumatic Brain Injury NCT04418440 | Queen Mary University of London | N/A |
| Unknown | Long-term Follow-up in Severe Traumatic Brain Injury NCT05235802 | Karolinska University Hospital | — |
| Completed | Plasticity of Deep Brain Structures in Mild Cognitive Impairment and Healthy Aging NCT06822283 | Friedhelm Hummel | N/A |
| Unknown | MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression NCT05009511 | Kessler Foundation | N/A |
| Withdrawn | Fundamental and Applied Concussion Recovery Modality Research and Development: Applications for the Enhanced R NCT05062148 | West Virginia University | N/A |
| Withdrawn | Cognitive Rehabilitation and Brain Activity of Attention-Control Impairment in TBI NCT04199130 | University of Florida | N/A |
| Completed | Near-infrared Spectroscopy (NIRS) for Intracranial Hematoma Detection NCT05189561 | National Institute of Mental Health and Neuro Sciences, India | N/A |
| Completed | NeuroAiD II™ (MLC901) in Mild Traumatic Brain Injury NCT04861688 | Moleac Pte Ltd. | Phase 3 |
| Completed | The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL NCT04901286 | Kessler Foundation | N/A |
| Unknown | Systemic Nitrosative/Oxidative Stress in Patients with Acute Brain Injury NCT04951453 | Rigshospitalet, Denmark | — |
| Completed | Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress NCT04935697 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Completed | Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers NCT04972786 | University of New Mexico | N/A |
| Recruiting | Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation NCT04869059 | The University of Texas at Dallas | N/A |
| Recruiting | Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury. NCT04349852 | NYU Langone Health | N/A |
| Terminated | Minor Traumatic Brain Injury : MRI Examination of Consequences and Social Insertion NCT04364568 | University Hospital, Grenoble | N/A |
| Completed | Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members NCT05183087 | Massachusetts General Hospital | — |
| Completed | The Use of LIFUP in Chronic Disorders of Consciousness NCT04921683 | Casa Colina Hospital and Centers for Healthcare | N/A |
| Completed | Genome-Wide Assocation Study in Patients With Brain Injury Associated Fatigue and Altered Cognition (BIAFAC) NCT04548180 | The University of Texas Medical Branch, Galveston | — |
| Recruiting | Non-invasive BCI-controlled Assistive Devices NCT05183152 | University of Texas at Austin | N/A |
| Unknown | Online Intervention for Traumatic Brain Injury Wellbeing NCT05115656 | Kessler Foundation | N/A |
| Unknown | Treatment of Spontaneous Hyperventilation With Remifentanil in Traumatic Brain Injury Patients NCT04974060 | Capital Medical University | N/A |
| Completed | Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury NCT05958277 | KRL Hospital, Islamabad | Phase 3 |
| Completed | Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis NCT04678115 | Massachusetts Eye and Ear Infirmary | N/A |
| Unknown | Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocri NCT04977843 | Jinnah Hospital | N/A |
| Active Not Recruiting | Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 NCT04602806 | University of California, San Francisco | — |
| Completed | SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI NCT04603443 | VA Office of Research and Development | N/A |
| Recruiting | Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI NCT04550377 | NYU Langone Health | Phase 2 |
| Completed | Translation of Modified Fatigue Impact Scale in Urdu Language NCT05405517 | Riphah International University | — |
| Unknown | Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study NCT04935866 | CHU de Quebec-Universite Laval | — |
| Enrolling By Invitation | Internet Delivered Cognitive Rehabilitation for Mild Cognitive Impairments NCT06973018 | Aniko Bartfai | N/A |
| Completed | Using Virtual Technologies to Prevent Injuries in Adolescents With Acquired Brain Injury NCT04768946 | Ohio State University | — |
| Completed | Comparison Between Effect of Vitamin D Versus Dexmedetomidine in Patients with Head Trauma Using Interleukin 6 NCT06565338 | Minia University | — |
| Recruiting | Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults NCT04521881 | London School of Hygiene and Tropical Medicine | Phase 3 |
| Completed | Emotional Processing Intervention for Children With TBI NCT04826068 | Kessler Foundation | N/A |