NCT04901286

The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL

The Effects of a Single Bout of Moderate Intensity Aerobic Exercise Combined With Different Environments on Executive Function and Processing Speed in Individuals With TBI

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Kessler Foundation · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Aerobic exercise is a promising treatment modality for cognition in persons with TBI, but effects are consistently small. This study aims to investigate the effect of difference environments during moderate intensity cycling sessions on cognition.

Detailed description

The proposed research study would be the first to investigate the acute effects of aerobic exercise with different environments relative to control and comparison conditions on several domains of cognition in people with TBI. This critical investigation will be a first step toward systematically identifying an optimal exercise training intervention for managing common cognitive consequences of TBI.

Conditions

• Traumatic Brain Injury

Interventions

Type	Name	Description
BEHAVIORAL	Exercise Only	Cycling in a lab environment
BEHAVIORAL	Exercise + Non-Immersive Virtual Reality	Cycling with an environment simulated by non-immersive virtual reality
BEHAVIORAL	Exercise + Immersive Virtual Reality	Cycling with an environment simulated by immersive virtual reality

Timeline

• Start date: 2021-08-19
• Primary completion: 2023-02-21
• Completion: 2023-03-30
• First posted: 2021-05-25
• Last updated: 2025-09-02

Locations

1 site across 1 country: United States