NCT05277519

Neuroplasticity After Proprioceptive Rehabiliation

Neuroplasticity Induced by Functional Muscle Tendon Vibrations in Patients With Acquired Brain Injury

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 56 (estimated)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. It is known that such a treatment promotes motor recovery after stroke assuming that it enhances neuroplasticity. The aim of the research is to study the activity in cerebrospinal circuitry to evaluate the neuroplastic changes during and after instrumented proprioceptive rehabilitation relying on sequences of muscle vibration in subacute stroke stages.

Detailed description

Randomized control trial : 28 patients with active vibrations vs. 28 patients with sham stimulation Subacute phase : D15 to 6 months after stroke or patients with traumatic brain injury with similar semiology as stroke (hemiparesis) Measure at baseline : Electrophysiological investigations (EMG,EEG, MRI, clinical evaluation) Treatment of 5 weeks with 3 sessions of vibrations or sham a week Evaluation at mid time (electrophysiology and clinical examinations) Final examination (electrophysiology, MRI and clinical examination)

Conditions

• Stroke
• Hemiparesis
• Traumatic Brain Injury

Interventions

Type	Name	Description
DEVICE	Vibrations	Sequenced muscle vibrations during 30 min., 3 times a week during 5 weeks

Timeline

• Start date: 2022-06-16
• Primary completion: 2026-06-15
• Completion: 2026-12-15
• First posted: 2022-03-14
• Last updated: 2026-03-09

Locations

1 site across 1 country: France