NCT07105358

Visual Plasticity Following Brain Lesions

Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Georgetown University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.

Conditions

• Visual Field Defect
• Stroke
• Hemianopia
• Quadrantanopia
• Cortical Blindness
• Brain Tumor
• Traumatic Brain Injury
• Visual Field Defect, Peripheral

Interventions

Type	Name	Description
DEVICE	transcranial random noise stimulation (tRNS)	Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: 1 mA current intensity, with a frequency range of 101-640 Hz.
DEVICE	Sham Stimulation	Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: Ramp up stimulation at 1mA with a frequency range of 101-640Hz for the first 30 seconds followed by no current for the remainder of the duration.
BEHAVIORAL	Perceptual learning-based training	A motion discrimination task, judging the global direction of moving dot stimuli with two different coherence levels.

Timeline

• Start date: 2025-07-17
• Primary completion: 2028-06-30
• Completion: 2028-06-30
• First posted: 2025-08-05
• Last updated: 2025-08-05

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study