NCT06718608

Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage. Patients will be assessed two weeks, one month, three months and six months after their brain lesion. Secondary objectives: To compare the muscle stiffness and structure of patients who will develop muscle overactivity to patients who won't develop muscle overactivity. To compare the muscle structure and muscle stiffness of the spastic lower limb muscles and the non-spastic lower limb muscles in the affected limb. To compare the muscle structure and muscle stiffness of the affected and the non-affected lower limb. To study the relationship between impairment and function by applying a comprehensive and original method to assess all aspects from muscle structure and mechanics to patient's functional capacities.

Conditions

• Stroke, Acute
• Traumatic Brain Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	imaging	Magnetic resonance imaging (MRI) Shear wave elastography (SWE) Electronic oscillatory device (EOD)

Timeline

• Start date: 2024-12-02
• Primary completion: 2025-12-31
• Completion: 2026-03-01
• First posted: 2024-12-05
• Last updated: 2024-12-05

Locations

1 site across 1 country: Belgium