NCT06846307

The Effect of Mannitol Volume with Changes in Osmolarity in Traumatic Brain Injury

The Effect of Mannitol Volume Administration with Changes in Osmolarity in Traumatic Brain Injury: an Observational Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Universitas Diponegoro · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This observational study is designed to research the effect of mannitol volume administration with changes in osmolarity in patients with traumatic brain injury to guide the safe use of mannitol in these patients.

Detailed description

This study used an analytic observational design with a prospective cohort approach to evaluate the relationship between mannitol administration volume and changes in osmolarity in TBI patients at Dr. Kariadi Central General Hospital, Semarang, Indonesia. The study included 32 non-operative TBI patients admitted to the Emergency Department (ED) and inpatient wards from November 2023 to January 2024. Samples were selected using a consecutive sampling method based on the inclusion criteria. The independent variable in this study was the volume of mannitol administered (3x125 cc, 2x250 cc, 3x250 cc; each 250 cc contains 50g mannitol) given as an IV drip for 15-20 minutes, while the dependent variable was blood osmolarity (mOsm/L).

Conditions

• Anesthesia
• Traumatic Brain Injury

Interventions

Type	Name	Description
DRUG	Mannitol	mannitol administration across all three dosages (3x125 cc, 2x250 cc, 3x250 cc) given as an IV drip for 15-20 minutes

Timeline

• Start date: 2023-11-01
• Primary completion: 2024-01-29
• Completion: 2024-01-31
• First posted: 2025-02-26
• Last updated: 2025-03-03

Locations

1 site across 1 country: Indonesia