Trials / Conditions / Major Depressive Disorder

Major Depressive Disorder

1,717 registered clinical trials studyying Major Depressive Disorder — 181 currently recruiting.

Status	Trial	Sponsor	Phase
Suspended	Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder NCT03787290	Massachusetts General Hospital	Phase 2
Not Yet Recruiting	Accelerated iTBS for Depression and Suicidality NCT04441008	University of Iowa	N/A
Not Yet Recruiting	Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder NCT06532604	Centre Psychothérapique de Nancy	N/A
Not Yet Recruiting	PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder NCT06452290	Central Hospital, Nancy, France	N/A
Not Yet Recruiting	Enhancing Veteran-Clinical Collaboration in VA PRRCs NCT06898879	VA Office of Research and Development	N/A
Not Yet Recruiting	Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression NCT07528157	Stanford University	N/A
Not Yet Recruiting	Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder NCT02129751	Bausch Health Americas, Inc.	Phase 4
Not Yet Recruiting	Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Dis NCT07503275	CHU de Reims	N/A
Recruiting	Peer-Delivered Behavioral Activation in a CCBHC NCT07219394	Wayne State University	N/A
Recruiting	Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocogni NCT06705478	National Institute of Allergy and Infectious Diseases (NIAID)	Phase 2
Not Yet Recruiting	Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT NCT07534475	Medipol University	N/A
Not Yet Recruiting	CARED : A Novel Rapid Treatment Paradigm for Depression NCT07507370	University of North Carolina, Chapel Hill	N/A
Not Yet Recruiting	Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments NCT06976840	Marta Peciña, MD PhD	N/A
Not Yet Recruiting	Mindfulness Engaged Neurostimulation for Depression (MEND II) NCT07512284	University of California, San Diego	Phase 2
Not Yet Recruiting	Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder NCT07427966	Karolinska Institutet	—
Not Yet Recruiting	Accelerated Treatment of Depressive Patients With tDCS NCT07444242	University of Regensburg	N/A
Recruiting	Neutralizing Interleukin (IL)-6 NCT07493317	Icahn School of Medicine at Mount Sinai	Phase 2
Not Yet Recruiting	Intradermal Acupuncture for Assisting SSRI Dose Reduction in Major Depressive Disorder NCT07390981	First People's Hospital of Hangzhou	N/A
Withdrawn	N2O for Acute Suicidality and Depression in the ED NCT05710887	University of Chicago	Phase 2
Not Yet Recruiting	Mitochondrial Function After Ketamine NCT07399756	Sheba Medical Center	—
Not Yet Recruiting	Testing a Precision Psychotherapy System for Low-income Patients NCT05118594	National Council of Scientific and Technical Research, Argentina	N/A
Not Yet Recruiting	Sustained Mood Improvement With Laughing Gas Exposure NCT07262008	Women's College Hospital	Phase 3
Not Yet Recruiting	A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients NCT03833206	BioLite, Inc.	Phase 1 / Phase 2
Enrolling By Invitation	NQ Square TMS for MDD 1Dx3S Adults Multi-site Sham-controlled Protocol NCT07369180	NeuroQore Inc.	N/A
Suspended	Transcranial Magnetic Stimulation for Youth With Treatment-Resistant Major Depressive Disorder NCT05652465	National Institute of Mental Health (NIMH)	Phase 2
Recruiting	A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder NCT07115329	Syndeio Biosciences, Inc	Phase 2
Recruiting	Exercise-priming of CBT for Depression: the CBT+ Trial NCT07221929	University of Wisconsin, Madison	N/A
Not Yet Recruiting	Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression NCT07174557	Dartmouth-Hitchcock Medical Center	N/A
Not Yet Recruiting	Stony Brook Medicine Anti-Inflammatory Trial NCT06699966	Stony Brook University	Phase 4
Recruiting	A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With NCT07276997	AbbVie	Phase 2
Recruiting	Integrated Suicide & Trauma Therapy for Suicide Risk NCT05613972	Unity Health Toronto	N/A
Not Yet Recruiting	Efficacy and Safety of Low-dose Laser Acupuncture on Treating Insomnia Associated With Major Depressive Disord NCT06443242	Mohammad Farris Iman Leong Bin Abdullah	N/A
Enrolling By Invitation	Mindfulness-Based Therapy for Serious Mental Illness NCT06880796	Butler Hospital	N/A
Recruiting	An Individual-specific Synchrony Signature NCT06749392	University of Haifa	N/A
Recruiting	Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness NCT07316803	Centre hospitalier de Ville-Evrard, France	N/A
Not Yet Recruiting	A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety NCT06820723	Ohio State University	Phase 2
Not Yet Recruiting	Therapy and Tech Study NCT07225192	University of California, Irvine	N/A
Enrolling By Invitation	To Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Food Effects of LY03021 in Healthy C NCT07371065	Luye Pharma Group Ltd.	Phase 1
Recruiting	Optimizing Brain Excitability in Depression NCT07242105	Stanford University	N/A
Recruiting	Cohort Study on Medical Students' Mental Health NCT07305701	Centre Hospitalier Régional d'Orléans	—
Recruiting	Stress Dynamics and Familial Risk for Depression in Female Adolescents NCT06816329	Mclean Hospital	N/A
Recruiting	An Empirical Study on the Mechanisms of Biopsychosocial Functional Improvement in Patients With Major Depressi NCT07180342	Shandong Provincial Hospital	N/A
Completed	Effectiveness of Traditional Chinese Metacognitive Training (MCT) in Patients With Schizophrenia, Depression, NCT07051746	ZI-YU LIN	N/A
Recruiting	A Study of Vortioxetine in Japanese Pediatric Patients With Major Depressive Disorder NCT07204314	Takeda	Phase 3
Recruiting	Using TMS to Understand Neural Processes of Social Motivation NCT06274112	Auburn University	N/A
Recruiting	Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics NCT05877885	AdventHealth	N/A
Recruiting	Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obes NCT07136714	Nordsjaellands Hospital	Phase 4
Recruiting	JAK Signaling in Depression NCT07003997	Emory University	Phase 2
Recruiting	Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy NCT07473648	The Second Hospital of Anhui Medical University	N/A
Recruiting	A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Re NCT07105111	Neurocrine Biosciences	Phase 4
Recruiting	Accelerated TMS for MDD NCT07147218	Neuronetics	N/A
Recruiting	A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Majo NCT07196501	Neurocrine Biosciences	Phase 3
Recruiting	Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD) NCT07111390	NYU Langone Health	N/A
Recruiting	Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (Pa NCT06979154	University of North Carolina, Chapel Hill	N/A
Recruiting	Antidepressant Response of DMT Masked With Propofol NCT06927076	University Hospital, Basel, Switzerland	N/A
Recruiting	Accelerated TMS for Perinatal Depression NCT06968390	Brigham and Women's Hospital	N/A
Enrolling By Invitation	Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) NCT06605105	Cybin IRL Limited	Phase 3
Recruiting	Ketamine Augmentation of ECT in Treatment-Resistant Depression NCT07088380	Università Vita-Salute San Raffaele	Phase 3
Recruiting	A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3) NCT07076407	Xenon Pharmaceuticals Inc.	Phase 3
Completed	Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive Therapy NCT07273851	Fauji Foundation Hospital	N/A
Completed	Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder NCT07526454	Tanta University	N/A
Not Yet Recruiting	Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling NCT06748950	Stanford University	N/A
Recruiting	The Friendship Bench Plus Trial NCT06384209	University of Bern	N/A
Completed	Feasibility Pilot of Accelerated Stimulation With TMS for Treatment of Major Depressive Disorder (FAST-MDD) NCT06961851	University of Minnesota	EARLY_Phase 1
Recruiting	Mood Effects of Serotonin Agonists: Depression NCT07017478	University of Chicago	EARLY_Phase 1
Recruiting	Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method NCT07028216	Georgetown University	N/A
Recruiting	NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Part NCT06963021	Neurocrine Biosciences	Phase 3
Recruiting	A Randomized Neuroimaging Trial of Psilocybin in Depression NCT06072898	Sunnybrook Health Sciences Centre	Phase 2
Recruiting	Temporal Interference and Depression NCT05295888	Unity Health Toronto	N/A
Recruiting	Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression Afte NCT05603104	Dr. Inge Winter	Phase 3
Recruiting	Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders NCT06450704	Fundación de Investigación Biomédica - Hospital Universitario de La Princesa	N/A
Recruiting	Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participant NCT06966401	Neurocrine Biosciences	Phase 3
Active Not Recruiting	A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge) NCT06941844	Definium Therapeutics US, Inc.	Phase 3
Recruiting	Maintenance rTMS for Depression (Maitr-De) NCT06938841	University of California, San Diego	N/A
Recruiting	In-patient SCC TMS NCT05645575	University of California, Los Angeles	N/A
Recruiting	Sensory Synchronized Imaging and Neuromodulation NCT06548113	VA Office of Research and Development	N/A
Recruiting	Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression NCT06724666	Babes-Bolyai University	N/A
Recruiting	NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Part NCT06911112	Neurocrine Biosciences	Phase 3
Recruiting	Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-I NCT06897670	Mayo Clinic	—
Not Yet Recruiting	The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patient NCT06826469	First Affiliated Hospital of Zhejiang University	N/A
Enrolling By Invitation	An Open-Label Study of Azetukalner in Major Depressive Disorder NCT06922110	Xenon Pharmaceuticals Inc.	Phase 3
Recruiting	Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation NCT06763081	University of Manitoba	—
Recruiting	Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder NCT06592833	Icahn School of Medicine at Mount Sinai	Phase 2
Enrolling By Invitation	Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric I NCT06823024	Psyrin Inc.	—
Completed	ENX-104 MAD Study for Participants With Major Depressive Disorder With Anhedonia (aMDD) NCT07253324	Engrail Therapeutics INC	Phase 1
Recruiting	Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder NCT06547489	Syndeio Biosciences, Inc	Phase 2
Recruiting	Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depress NCT06507787	Alcediag	N/A
Recruiting	Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness NCT06376734	Brigham and Women's Hospital	Phase 2
Recruiting	Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major D NCT06786624	Neurocrine Biosciences	Phase 3
Withdrawn	Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT NCT06733558	University of New Mexico	EARLY_Phase 1
Recruiting	Psilocybin rTMS for Treatment Resistant Depression NCT06132178	University of Texas at Austin	Phase 2
Recruiting	Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression NCT06559826	Icahn School of Medicine at Mount Sinai	Phase 2
Recruiting	Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults NCT06860724	University of Delaware	N/A
Recruiting	The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression NCT06163625	Unity Health Toronto	N/A
Recruiting	Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents NCT06523439	University of Texas at Austin	N/A
Not Yet Recruiting	Effective of Transcranial Magnetic Stimulation (TMS) vs Treatment as Usual for First-Episode Depression in Adu NCT06644833	Sultan Qaboos University	Phase 4
Recruiting	A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder NCT06775379	Xenon Pharmaceuticals Inc.	Phase 3
Recruiting	Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder NCT06695767	The University of Texas Health Science Center, Houston	N/A
Recruiting	"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" NCT06564818	Cybin IRL Limited	Phase 3
Completed	Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depr NCT06746441	Khyber Medical University Peshawar	Phase 2
Enrolling By Invitation	Precision Care for Major Depressive Disorder NCT06580041	University of California, San Francisco	Phase 4
Completed	A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case NCT06655623	Region of Southern Denmark	N/A
Recruiting	Treating Loneliness In The Older Adult With Depression With tDCS NCT06658795	Guangzhou Psychiatric Hospital	N/A
Active Not Recruiting	Individualized Targeting and Neuromodulation of Late-Life Depression NCT04543773	University of New Mexico	N/A
Recruiting	Comorbid Obesity and Depression With an Anti-inflammatory Medication NCT06537921	King's College London	N/A
Completed	Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression NCT06730841	University of California, San Diego	N/A
Recruiting	Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY) NCT06633016	Autobahn Therapeutics, Inc.	Phase 2
Recruiting	Physical Activity Program for TRD NCT06404320	Unity Health Toronto	N/A
Not Yet Recruiting	Effects of rTMS Compared to SSRI as Early Treatment of Depression (Early-TMS) NCT06545474	University Hospital Tuebingen	N/A
Recruiting	The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder NCT06247839	Sharmin Ghaznavi	Phase 3
Recruiting	Natural History of Depression, Bipolar Disorder and Suicide Risk NCT06462196	National Institute of Mental Health (NIMH)	—
Active Not Recruiting	Testing a Transdiagnostic TMS Treatment Target NCT06282146	Brigham and Women's Hospital	EARLY_Phase 1
Completed	Effects of Ghrelin Administration on Motivation NCT06576440	University Hospital Tuebingen	N/A
Recruiting	Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depr NCT06610305	University of North Carolina, Chapel Hill	Phase 4
Withdrawn	Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD) NCT04594616	Massachusetts General Hospital	N/A
Recruiting	Imaging Depression in Parkinson's Disease NCT06402955	Yale University	Phase 2
Recruiting	Taking Action for College Students NCT06700902	Temple University	N/A
Enrolling By Invitation	Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Popu NCT05989412	Erasmus Medical Center	N/A
Recruiting	The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treat NCT05973851	Dr. Inge Winter	Phase 3
Not Yet Recruiting	A Biological Signature for the Early Differential Diagnosis of Psychosis NCT06515522	IRCCS San Raffaele	—
Recruiting	Self-Identification Program NCT06183359	University Hospital, Montpellier	N/A
Recruiting	A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Dep NCT06570369	Sirtsei Pharmaceuticals, Inc.	Phase 1
Recruiting	Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilo NCT06626152	University of British Columbia	Phase 2
Recruiting	Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulat NCT06542094	West China Hospital	N/A
Completed	Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD) NCT06423781	Biohaven Therapeutics Ltd.	Phase 2
Enrolling By Invitation	Cortical rTMS as a Treatment for Depression NCT05487911	Baylor College of Medicine	N/A
Completed	Transcranial Direct Current Stimulation (tDCS) in Young Individuals with Major Depressive Disorder: a Literatu NCT06518642	The University of Hong Kong	N/A
Completed	Amygdala TIS for Depression NCT06477276	Ruijin Hospital	N/A
Recruiting	Sleep Modulation to Treat Depression NCT06443216	Christoph Nissen	N/A
Active Not Recruiting	Psilocybin for Treatment-Resistant Depression NCT06230757	University of Colorado, Denver	Phase 2
Recruiting	Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy NCT06529029	Michigan State University	Phase 2 / Phase 3
Terminated	The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition NCT03693105	Magnus Medical	Phase 2 / Phase 3
Terminated	SAINT for MDD in an Inpatient Setting Follow-on NCT06462820	Magnus Medical	Phase 2 / Phase 3
Enrolling By Invitation	Operation of Brain Stimulation Equipment Under Remote Viewing Effectiveness Registry NCT06512324	Biomedical Discoveries and Neuroscientific Foundations LLC	—
Completed	Diet and Depression NCT06252701	University of California, San Francisco	N/A
Recruiting	Whole-body Hyperthermia for Depression NCT06323785	University of Zurich	N/A
Suspended	Evaluation of Response to a Course of Repetitive Transcranial Magnetic Stimulation Using Vocal Biomarkers NCT06451835	GCS CIPS	—
Suspended	Prediction of the Response to a Course of Transcranial Magnetic Stimulation (rTMS) Based on Heart Rate Variabi NCT06451809	GCS CIPS	—
Not Yet Recruiting	Exergames-acceptance and Commitment Therapy Program for Treatment of Major Depressive Disorder NCT05812001	Universiti Sains Malaysia	N/A
Completed	A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Se NCT05932407	Takeda	—
Not Yet Recruiting	Clinical, Cognitive and Neural Effects of Potentiation of ECT by rTMS in Treatment-Resistant Depression NCT06391723	Centre Hospitalier du Rouvray	N/A
Recruiting	Improving Treatment of Major Depressive Disorder by Reducing Negative Future-Oriented Mental Imagery NCT06454695	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	N/A
Completed	Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline NCT06466655	University of Delaware	N/A
Completed	A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET NCT06476509	Vigonvita Life Sciences	Phase 1
Not Yet Recruiting	To Evaluate the Long-term Efficacy and Safety of Toludevenlafaxine Hydrochloride Sustained-release Tablets NCT06426485	Luye Pharma Group Ltd.	Phase 4
Active Not Recruiting	Individualized (fMRI-guided) TMS Treatment for Depression NCT06266390	University of Pennsylvania	N/A
Completed	Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression NCT06419608	Biohaven Therapeutics Ltd.	Phase 2
Recruiting	Relevance of a Telemedicine Monitoring in the Management of Depression NCT06076317	Assistance Publique - Hôpitaux de Paris	N/A
Recruiting	Amygdala MRI-TIS for Depression NCT06461260	Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University	N/A
Recruiting	Amygdala and dLPFC MRI-TIS for Depression in Adolescents NCT06452849	Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University	N/A
Active Not Recruiting	Mindfulness Engaged Neurostimulation for Depression NCT06399406	University of California, San Diego	Phase 2
Withdrawn	First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM) NCT05921929	ReST Therapeutics	Phase 1
Recruiting	Trial of Mirtazapine for Depression in IBD NCT06309472	King's College London	Phase 2
Recruiting	Pharmacologic Treatment Augmentation in Chronic Depression NCT06410599	University Hospital Tuebingen	Phase 2
Completed	New Investigational Stimulation Protocol for Treatment of Major Depression Disorder (MDD) NCT06357832	Brainsway	N/A
Recruiting	pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression NCT06350396	Changping Laboratory	N/A
Withdrawn	Sleep Quality, Cognitive Performance, and Computerized Cognitive Training NCT06328140	George West Mental Health Foundation d/b/a Skyland Trail	—
Recruiting	Impact of Psychomotor Therapy on the Quality of Life in Depression NCT06234176	Centre Hospitalier Esquirol	N/A
Not Yet Recruiting	Stress Management in Depressive Disorder: Resilience Training vs. Yoga: Biological, Epigenetic, and Brain Corr NCT06229652	Medical University Innsbruck	N/A
Recruiting	A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder NCT06254612	Sirtsei Pharmaceuticals, Inc.	Phase 2
Completed	PD, PK, and Safety of ALTO-203 in Patients With MDD NCT06391593	Alto Neuroscience	Phase 2
Recruiting	Adolescent Interpersonal Counseling in Primary Care NCT06390462	Finnish Institute for Health and Welfare	—
Recruiting	Regulation of Affect and Physiology in Depression NCT06345859	University of Southern California	Phase 2
Completed	A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder NCT06267846	Neurocrine Biosciences	Phase 2
Completed	Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol NCT06360419	Axsome Therapeutics, Inc.	Phase 3
Recruiting	Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neuro NCT06050070	University of Michigan	N/A
Recruiting	Targeting Specific Brain Networks to Treat Specific Symptoms in Depression NCT05523817	Massachusetts General Hospital	N/A
Completed	Standardized Assessment in Depression Treatment in Routine Psychiatric Services NCT06332261	Karolinska Institutet	—
Not Yet Recruiting	Ketamine Treatment for PTSD and MDD in TBI NCT06228391	Minneapolis Veterans Affairs Medical Center	Phase 2
Unknown	pBFS Guided rTMS Over Different Targets for Treatment-Resistant Depression NCT06255561	Changping Laboratory	N/A
Recruiting	Relationship Between Major Depression and Periodontal Diseases NCT05950009	Universidad Complutense de Madrid	—
Suspended	Low-Intensity Focused Ultrasound for Treatment-Resistant Depression NCT06013384	Medical University of South Carolina	N/A
Recruiting	Getting Out of the House: Using Behavioral Activation to Increase Community Participation NCT06336616	Temple University	N/A
Completed	Open-Label of SPN-820 in Adults With Major Depressive Disorder NCT06235905	Navitor Pharmaceuticals, Inc.	Phase 2
Completed	Positive Feedback vs. No-Feedback Games for Behavioral Change NCT06025838	Bard College	N/A
Recruiting	Behavioral Activation for Depression and Habitual Rumination NCT06322420	Ragnar Pétur Ólafsson	N/A
Recruiting	Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psiloc NCT06341426	University Health Network, Toronto	Phase 2
Completed	Study Evaluating Safety and Efficacy of Ropanicant in MDD Patients NCT06126497	Suven Life Sciences Limited	Phase 2
Completed	A Clinical Study to Evaluate of Single and Multiple Oral Doses of GM-1020 in Patients With MDD NCT06309277	Gilgamesh Pharmaceuticals	Phase 2
Recruiting	A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD NCT06236880	Gilgamesh Pharmaceuticals	Phase 2
Recruiting	Neural Circuit Effects of Ketamine in Depression NCT06213324	Icahn School of Medicine at Mount Sinai	Phase 4
Unknown	Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression NCT06211140	Xuanwu Hospital, Beijing	N/A
Recruiting	Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression NCT06132581	Florida State University	N/A
Unknown	Predictors of Intravenous Ketamine Response in TRD NCT05625555	Abraham Nunes	Phase 3
Unknown	Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis NCT06329414	University of Utah	—
Unknown	Ketogenic Diet Therapy Major Depressive Disorder NCT05558995	Queen's University	N/A
Recruiting	i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Cl NCT06480500	University Health Network, Toronto	Phase 2
Recruiting	RESISTance Exercise for Depression Trial NCT06110897	University of Wisconsin, Madison	N/A
Withdrawn	Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder NCT03804619	Stanford University	N/A
Suspended	Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression NCT06480201	Texas A&M University	Phase 1
Not Yet Recruiting	Feasibility of Conducting a Clinical Trial Assessing Efficacy of Lactate as Adjunctive Therapy in Patients Wit NCT06168175	Centre Hospitalier Universitaire Vaudois	Phase 2
Withdrawn	Psilocybin for Major Depressive Disorder NCT05675800	Washington University School of Medicine	Phase 2
Active Not Recruiting	Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression NCT05902312	Centre hospitalier de l'Université de Montréal (CHUM)	N/A
Not Yet Recruiting	Ketogenic Diet for Depression NCT06105762	University Psychiatric Clinics Basel	N/A
Recruiting	A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Sympt NCT06223880	Axsome Therapeutics, Inc.	Phase 4
Active Not Recruiting	Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder NCT06058039	Neumora Therapeutics, Inc.	Phase 3
Active Not Recruiting	Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder NCT06058013	Neumora Therapeutics, Inc.	Phase 3
Completed	The CARE (Collaborative Adolescent Running Experience) Project NCT05837351	University of Michigan	N/A
Recruiting	Neuromodulation of Different Doses to Treat TRD Guided by pBFS Technique NCT06112652	Changping Laboratory	N/A
Recruiting	Behavioral and Neuronal Correlates of Human Mood States NCT06159595	Stanford University	N/A
Recruiting	Study to Assess the Safety and Effectiveness of NMRA-335140-501 NCT06029439	Neumora Therapeutics, Inc.	Phase 3
Unknown	rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS NCT06095778	Changping Laboratory	N/A
Unknown	Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With NCT05889234	First Affiliated Hospital of Chongqing Medical University	—
Completed	Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder NCT05399498	University of Chicago	Phase 2
Recruiting	Positioning of Esketamine Treatment in the Real-world Management of Depression NCT06103760	Royal North Shore Hospital	Phase 4
Recruiting	Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer NCT05947383	Sunstone Medical	Phase 2
Unknown	Acquisition and Analysis of Relationships Between Longitudinal Emotional Signals Produced by an Artificial Int NCT05988840	Emobot	—
Active Not Recruiting	Self-guided Treatment for Depression NCT06028984	Big Health Inc.	N/A
Completed	Vulnerability Markers for Depression NCT06402422	The Hong Kong Polytechnic University	—
Recruiting	40 Hz Light Neurostimulation for Patients With Depression (FELIX) NCT05680220	Klaus Martiny	N/A
Terminated	Alexithymia Intervention for Suicide NCT05724953	VA Office of Research and Development	Phase 1
Recruiting	RIVER At Home Ketamine Protocols NCT06070766	RIVER Foundation	—
Recruiting	Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression NCT05892744	University of Texas at Austin	Phase 4
Recruiting	5-HTP and Creatine for Depression R33 Phase NCT05895747	University of Utah	Phase 2
Recruiting	Interleaved TMS-fMRI in Ultra-treatment Resistant Depression NCT05813093	Sunnybrook Health Sciences Centre	N/A
Unknown	Assessing Dopamine Transporter Occupancy in the Patients With Depression Brain With Toludesvenlafaxine Hydroch NCT06026917	Shanghai Mental Health Center	Phase 4
Active Not Recruiting	EMA-Guided Maintenance TMS for Depression NCT06145594	Butler Hospital	N/A
Recruiting	INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder NCT05644301	Universiteit Antwerpen	Phase 3
Completed	Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorde NCT06029426	Neumora Therapeutics, Inc.	Phase 3
Recruiting	Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality NCT05925322	Weill Medical College of Cornell University	N/A
Recruiting	Positive Processes and Transition to Health (PATH) NCT06093906	Case Western Reserve University	N/A
Recruiting	Prediction of the Therapeutic Response in Depression Based on Neuro-computational Modeling Assessment of Motiv NCT05866575	Centre Hospitalier St Anne	N/A
Unknown	Brain Oscillation-synchronized Stimulation of the Frontal Cortex in Major Depressive Disorder NCT06345651	University Hospital Tuebingen	N/A
Completed	CBT+ for Depression NCT06001346	University of Wisconsin, Madison	N/A
Unknown	Personalized, Predictive, Precise & Preventive Medicine for Major Depression NCT06027177	Hannover Medical School	—
Recruiting	Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysi NCT05996900	Stanford University	N/A
Completed	Frequency and E-field Enhancement of ITBS for Depression (FREED) NCT06003309	University of California, San Diego	N/A
Completed	Rise Study for Depression NCT06003361	Big Health Inc.	N/A
Unknown	pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression NCT05976009	Changping Laboratory	N/A
Recruiting	Presynaptic Imaging in Major Depressive Episodes After COVID-19 NCT06086366	Centre for Addiction and Mental Health	—
Completed	Musical Attention Control and Executive Function Training for Adults With MDD NCT05694156	Unity Health Toronto	N/A
Terminated	Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD NCT06011577	Levomecor Inc.	Phase 3
Enrolling By Invitation	Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements NCT06002100	Kernel	—
Recruiting	Imagery Rescripting as Treatment for Depression NCT05976945	University of Amsterdam	N/A
Active Not Recruiting	Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive NCT06550037	Alessio Fasano	—
Unknown	pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression NCT05976022	Changping Laboratory	N/A
Enrolling By Invitation	Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics NCT05910957	Mayo Clinic	—
Completed	Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness NCT05725785	University of Washington	N/A
Unknown	Using Sleep Wearables to Adapt Cognitive-behavioral Therapy for Insomnia in the Context of Depression (CBTiA) NCT05990855	University of Ottawa	N/A
Unknown	pBFS Guided 20min Inter-session Interval rTMS Treatment for MDD NCT05957341	Changping Laboratory	N/A
Unknown	pBFS-guided High-dose TMS Over DMPFC for Treatment-resistant Major Depressive Disorder NCT05964036	Changping Laboratory	N/A
Completed	Microdosing Psychedelics to Improve Mood NCT05259943	Rotem Petranker	Phase 2
Recruiting	Network Neurofeedback Using 7-Tesla MRI to Reduce Rumination Levels in Depression NCT05933148	Icahn School of Medicine at Mount Sinai	N/A
Unknown	pBFS Guided rTMS Over DMPFC for Treatment-Resistant Depression NCT05948839	Changping Laboratory	N/A
Unknown	The Dosage Effect of pBFS Guided rTMS Treatment for MDD NCT05842278	Changping Laboratory	N/A
Withdrawn	PET Synaptogenesis After Psilocybin In DEpression Recovery NCT05601648	Washington University School of Medicine	Phase 2
Recruiting	Non-invasive BCI and Application Verification for Depressed People NCT06417437	Shanghai Mental Health Center	Phase 4
Unknown	Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treat NCT05785312	Khushal Khan Khattak Univeristy, Karak, Pakistan	N/A
Completed	The Role of Social Determinants in Cardiovascular Health and Vascular Function NCT05772221	Baylor Research Institute	N/A
Completed	Psilocybin-assisted CBT for Depression NCT05227612	University of California, Los Angeles	Phase 1
Completed	A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion NCT06372210	Otsuka Pharmaceutical Development & Commercialization, Inc.	N/A
Completed	Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation NCT05893173	University of Pennsylvania	—
Unknown	Prospective Clinical Cohort Study of Depression NCT05775809	Sir Run Run Shaw Hospital	—
Unknown	Exosome for Early Diagnosis of Bipolar Affective Disorder NCT05915312	Tianjin Anding Hospital	—
Active Not Recruiting	Home-based Non-invasive Brain Stimulation for Treatment-resistant Depression Feasibility, Efficacy and Biomark NCT05930509	Institut Guttmann	N/A
Recruiting	Study of ALTO-300 in MDD NCT05922878	Alto Neuroscience	Phase 2
Recruiting	Amygdala Neurofeedback for Depression - Large Scale Clinical Trial NCT05703256	Kymberly Young	N/A
Recruiting	EEG Microstates Across At-Risk Mental States NCT06045897	Centre Hospitalier St Anne	N/A
Completed	Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tar NCT05859698	Neurocrine Biosciences	Phase 4
Recruiting	Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder NCT05850689	Intra-Cellular Therapies, Inc.	Phase 3
Active Not Recruiting	Clinical Validation of Samsung Smartwatch NCT05767593	Massachusetts General Hospital	—
Recruiting	Neural Mechanisms of Intermittent Theta Burst Stimulation in the Core Depression Network NCT05224206	The Royal Ottawa Mental Health Centre	N/A
Active Not Recruiting	D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT) NCT05591677	The Alfred	Phase 2
Completed	Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depr NCT06232291	Medical University of Gdansk	—
Completed	Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD) NCT05655507	Biogen	Phase 1
Completed	Deep rTMS for Depression in Older Adults NCT05855850	St. Joseph's Healthcare Hamilton	N/A
Active Not Recruiting	Open Label Optimization Study NCT05819021	Magnus Medical	—
Active Not Recruiting	Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation NCT06043401	Medical University of South Carolina	—
Recruiting	The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects NCT05786066	Yale University	Phase 2
Recruiting	Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis NCT05051618	University of Illinois at Chicago	N/A
Recruiting	Metabolic Profiling of Esketamine Treatment in Depressive Disorder NCT07002684	University of Zagreb	—
Recruiting	Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33 NCT05573074	NYU Langone Health	N/A
Completed	Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients NCT06372834	Tri-Service General Hospital	N/A
Unknown	The Relationship Between Emotion Regulation and Psychiatric Disorder in Youth NCT06271954	Chang Gung Memorial Hospital	—
Completed	Mental Health Assessment and Prescribing by Alberta Pharmacists NCT04410575	University of Alberta	N/A
Recruiting	Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD) NCT05757791	NYU Langone Health	Phase 2
Recruiting	Evaluation of a Male-specific Psychotherapeutic Program for Major Depressive Disorders NCT05435222	Andreas Walther	N/A
Completed	Study of Virtual Reality-based Medical Device for Patients with Depressive Disorder NCT05701345	Omni C&S	N/A
Completed	SMILE Trial - Imaging Sub-Study NCT05528718	Unity Health Toronto	—
Recruiting	Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV NCT05570812	Massachusetts General Hospital	Phase 2
Unknown	Immune Activation, Neural Plasticity and Depression NCT06306248	IRCCS San Raffaele	—
Completed	Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Exten NCT05905120	Shanghai Mental Health Center	Phase 1
Recruiting	Pain and Major Depressive Disorder NCT04556890	University of California, Los Angeles	N/A
Completed	Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD NCT05717439	Senseye, Inc.	—
Unknown	"Mamá, te Entiendo" App-based Intervention for Reducing Depressive Symptoms in Postpartum Women NCT05643898	Pontificia Universidad Catolica de Chile	N/A
Recruiting	DBS for TRD With the Medtronic Percept PC NCT05773755	Helen Mayberg, MD	N/A
Completed	The Utility of Concurrent TBS/fNIRS for Antidepressant Treatment Optimization NCT04526002	Dr Georg Kranz	N/A
Unknown	TaKeTiNa in the Treatment of Depression: a Pilot Study. NCT05778643	University of Erlangen-Nürnberg Medical School	N/A
Recruiting	Decoding and Modulating Affective Brain States NCT05437705	University of Pennsylvania	N/A
Completed	HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2 NCT05708976	University of California, San Francisco	N/A
Completed	Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression NCT05772702	Electromedical Products International, Inc.	N/A
Unknown	the Safety and Effectiveness of Precise rTMS Based on Neuroimaging in the Treatment of Adolescent Depression W NCT05544071	Xijing Hospital	N/A
Completed	Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulat NCT05693922	University of North Carolina, Chapel Hill	N/A
Recruiting	Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pat NCT05913960	First Affiliated Hospital of Zhejiang University	N/A
Recruiting	Defining Neurobiological Links Between Substance Use and Mental Illness NCT05538910	National Institute on Drug Abuse (NIDA)	N/A
Unknown	The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brai NCT05707299	The Third Affiliated hospital of Zhejiang Chinese Medical University	N/A
Active Not Recruiting	A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, P NCT05733546	COMPASS Pathways	Phase 2
Unknown	Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults NCT05976659	Hebrew SeniorLife	N/A
Recruiting	Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) NCT05017311	Nova Scotia Health Authority	Phase 4
Completed	An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characteriz NCT05666687	Novartis Pharmaceuticals	Phase 1

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