NCT06027177

Personalized, Predictive, Precise & Preventive Medicine for Major Depression

P4D - Personalized, Predictive, Precise & Preventive Medicine for Major Depression

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Hannover Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Depressive disorders are among the most common psychiatric disorders. However, this disorder is multifaceted, as are its etiological factors, and is not yet fully understood. Within the framework of the P4D study, 1000 patients with depression will be comprehensively examined. In addition to the recording of psychological factors by means of questionnaires and third-party assessments, imaging and electrophysiological procedures (functional and structural MRI, EEG) are used to assess brain structure and function. In addition, blood is drawn from the subjects to analyze these samples for various biological markers (e.g., genetics). Drug level measurements are also performed. The goal is to perform an in-depth characterization (phenotyping) of individuals with a depressive disorder. These findings could be used to individualize and improve therapy for depressive disorders.

Conditions

• Major Depressive Disorder
• Persistent Depressive Disorder

Timeline

• Start date: 2023-09-01
• Primary completion: 2025-08-01
• Completion: 2025-08-01
• First posted: 2023-09-07
• Last updated: 2023-09-07