NCT06252701

Diet and Depression

Assessing the Feasibility and Acceptability of the Reduction of Ultra-processed Foods From the Diets of a Subset of Patients With Depression - A Pilot Open Label Crossover Trial.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.

Detailed description

There is a need for additional treatment or augmentation strategies for people who have depression. Epidemiological and observational studies show that an increased consumption of ultra-processed food (UPF) is associated with an increased risk of developing depression. This study will test the hypothesis that that reducing UPF intake from the diets of patients with major depressive disorder who eat a large percentage of UPF is a feasible and acceptable intervention.

Conditions

• Depression
• Major Depressive Disorder
• Weight Gain
• Obesity
• Metabolic Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Reduction of Ultra-processed foods	Reduction of Ultra-processed foods for four weeks.

Timeline

• Start date: 2024-06-18
• Primary completion: 2025-06-18
• Completion: 2025-06-18
• First posted: 2024-02-12
• Last updated: 2025-11-21

Locations

1 site across 1 country: United States