NCT07473648

Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: The Second Hospital of Anhui Medical University · Academic / Other
• Sex: All
• Age: 12 Years – 80 Years
• Healthy volunteers: Accepted

Summary

To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).

Conditions

• Electroconvulsive Therapy
• Major Depressive Disorder
• Magnetic Seizure Therapy

Interventions

Type	Name	Description
DEVICE	Electroconvulsive Therapy	Electroconvulsive therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.
DEVICE	Magnetic Seizure Therapy	Magnetic seizure therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.
OTHER	Cognitive and Behavioral Assessment	Participants will undergo a series of standardized cognitive tests (e.g., MCCB) and behavioral assessments (e.g., clinical rating scales) at specified time points. This does not constitute a therapeutic intervention but is for the purpose of data collection to establish normative baseline performance.

Timeline

• Start date: 2025-09-01
• Primary completion: 2027-12-01
• Completion: 2028-01-01
• First posted: 2026-03-16
• Last updated: 2026-03-16

Locations

1 site across 1 country: China