Trials / Unknown
UnknownNCT05976659
Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
Targeting Depression And Memory Symptoms With Multi-Focal Circuit-Based Neuromodulation
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- Sponsor
- Hebrew SeniorLife · Academic / Other
- Sex
- All
- Age
- 55 Years
- Healthy volunteers
- Not accepted
Summary
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD) in the context of dementia.
Detailed description
This is a single arm pilot study to determine safety, feasibility, and preliminary efficacy of a home-based brain stimulation intervention of transcranial direct current stimulation (tDCS) targeting the prefrontal cortex, and transcranial alternating stimulation (tACS) targeting the angular gyrus to improve depressive and episodic memory symptoms in individuals with major depressive disorder (MDD) in the context of dementia. Participants will take part in a series of pre-intervention assessments, the brain stimulation intervention consisting of 20 once-daily 20-minute stimulation sessions given over a period of 4 weeks, and a series of post-intervention assessments (taken immediately after brain stimulation and 3 months after stimulation).
Conditions
- Major Depressive Disorder
- Alzheimer Disease
- Dementia
- Nervous System Diseases
- Memory Disorders
- Depressive Disorder
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Transcranial direct current stimulation (tDCS); Transcranial alternating current stimulation (tACS) | Transcranial electrical stimulation (tES), via direct and alternating current, will be administered to the participants in their home by trained caregivers/study companions administrators. All training and intervention sessions will take place in the participant's home. |
Timeline
- Start date
- 2023-01-24
- Primary completion
- 2025-01-31
- Completion
- 2025-06-30
- First posted
- 2023-08-04
- Last updated
- 2023-08-04
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT05976659. Inclusion in this directory is not an endorsement.