| Not Yet Recruiting | ACT for Veterans With IBD and Mental Health Challenges NCT07397195 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Sleep Disturbances and Their Association With Serum Magnesium Level in Patients With Major Depressive Disorder NCT07198477 | Assiut University | — |
| Not Yet Recruiting | Mindfulness Engaged Neurostimulation for Depression (MEND II) NCT07512284 | University of California, San Diego | Phase 2 |
| Not Yet Recruiting | The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study NCT06206226 | University of Wisconsin, Madison | N/A |
| Recruiting | The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders NCT07458100 | Peking University | N/A |
| Not Yet Recruiting | Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patie NCT07454070 | Jing Han | N/A |
| Recruiting | Enhancing Brain And Mental Health Through Breathing Practice NCT07369752 | Mayo Clinic | N/A |
| Not Yet Recruiting | Validation of the Accuracy of an AI-Based System for Diagnosing Depressive Disorders NCT07311668 | Shanghai Mental Health Center | — |
| Not Yet Recruiting | iTBS-Neurosplasticity for Female Youth With Depression NCT06746857 | University of British Columbia | N/A |
| Enrolling By Invitation | Stereotactic Radiotherapy Treatment for Treatment-resistant Depression NCT07274917 | Capital Medical University | N/A |
| Recruiting | Psychological State, Immunotherapy Response, and Multi-Omics Signatures in TNBC NCT07290153 | Fudan University | — |
| Not Yet Recruiting | Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental NCT07060690 | Francesc Colom, PsyD, PhD | N/A |
| Recruiting | Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan. NCT07263321 | Aalborg University Hospital | N/A |
| Not Yet Recruiting | Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly P NCT07153406 | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Phase 3 |
| Recruiting | IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVI NCT07197138 | Max-Planck-Institute of Psychiatry | N/A |
| Recruiting | Assessment of Daily Stressors in Children With Depressive Symptoms for the Development of a Gamified Emotion R NCT07159347 | Ludwig-Maximilians - University of Munich | — |
| Recruiting | Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder NCT07191392 | The Second Hospital of Anhui Medical University | N/A |
| Completed | Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptom NCT06970964 | Federal University of São Paulo | N/A |
| Not Yet Recruiting | Therapeutic Writing for Adults Suffering From Chronic Pain and Comorbid Mental Health Disorders NCT07058532 | Toni Salikka | N/A |
| Not Yet Recruiting | Clinical Effect and Mechanism Study of Five Elements Music Therapy(FEMT) on Depression Disorder NCT07048938 | Shanghai Mental Health Center | N/A |
| Recruiting | Comparing Brief Psychoanalytic Couple Therapy and Emotionally Focused Therapy in Reducing Relationship Distres NCT07100951 | Beykoz University | N/A |
| Recruiting | Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice NCT07022184 | Radboud University Medical Center | N/A |
| Recruiting | Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave NCT06890208 | Universitätsklinikum Hamburg-Eppendorf | — |
| Recruiting | EL-SHIN Therapy for Depressive Symptoms NCT06995807 | Monash University Malaysia | N/A |
| Completed | A Qualitative Analysis of Youth Responses to Depression Education Delivered on Social Media NCT07100548 | Ludwig-Maximilians - University of Munich | — |
| Recruiting | A Randomized Neuroimaging Trial of Psilocybin in Depression NCT06072898 | Sunnybrook Health Sciences Centre | Phase 2 |
| Not Yet Recruiting | DIALOG: Understanding Disorganisation: A Language-focused Global Initiative in Psychosis NCT06978465 | Douglas Mental Health University Institute | — |
| Enrolling By Invitation | Development and Evaluation of a Digital Aftercare Program for Adolescents (12-17 Years) With Depressive Sympto NCT07007247 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Not Yet Recruiting | Unified Protocol for Treatment of Emotional Disorders in Brief Groups in Primary Care Services in Spain NCT06547450 | Instituto de Investigación Sanitaria Aragón | N/A |
| Completed | Problem Management Plus (PM+) in Chile: a Pilot Randomized Controlled Trial of a Psychological Transdiagnostic NCT06988332 | University of Chile | N/A |
| Not Yet Recruiting | Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Sui NCT06957704 | Federal University of São Paulo | Phase 3 |
| Recruiting | Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity. NCT06901739 | Celia Bañuls | N/A |
| Enrolling By Invitation | Psychopathology in Adolescence NCT07259109 | IRCCS Centro Neurolesi Bonino Pulejo | — |
| Completed | Enhancing Depression Literacy and Reducing Stigma in Adolescents Through Social Media NCT07061600 | Ludwig-Maximilians - University of Munich | N/A |
| Recruiting | Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression NCT06724666 | Babes-Bolyai University | N/A |
| Recruiting | Body Awareness in People With Depressive Disorder NCT06879977 | Johannes Kepler University of Linz | — |
| Recruiting | Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression NCT07022171 | Max-Planck-Institute of Psychiatry | N/A |
| Recruiting | Gut Microbiota in IBD With Comorbid Depressive Disorder NCT07252427 | Fang Tang | — |
| Recruiting | 7T Amygdala and Citalopram Study NCT06412315 | University of Oxford | N/A |
| Recruiting | A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression NCT06981000 | University of Copenhagen | N/A |
| Recruiting | Islamic-Oriented vs. Standard Ericksonian Hypnotherapy for Anxiety and Depression NCT06844058 | Istanbul Nisantasi University | N/A |
| Not Yet Recruiting | Multiple-Family Group Intervention Programming to Improve Mental Health of Adolescents Living With HIV in Ghan NCT06701942 | University of Ghana | N/A |
| Withdrawn | Pilot Study: Investigating Mood Changes After Slow-wave Enhancement NCT05146427 | University of Pennsylvania | N/A |
| Not Yet Recruiting | Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Ac NCT06705179 | California Institute of Technology | N/A |
| Active Not Recruiting | Detection Algorithm for Recurrence or Relapse of Depression Thanks to a Smartwach NCT06789822 | Dalia Care | N/A |
| Recruiting | A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults NCT06508450 | New York University | N/A |
| Completed | Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression NCT06650800 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Recruiting | Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Trea NCT06511908 | National Institute of Mental Health (NIMH) | Phase 2 |
| Not Yet Recruiting | Feasibility of Integrated Care of Depression in Primary Care Pathways NCT06036160 | Association De La Msp Pasteur | N/A |
| Active Not Recruiting | PRISM for Depression and Anxiety in Young Adults With Cancer NCT06502483 | Dana-Farber Cancer Institute | N/A |
| Recruiting | Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression NCT06898606 | Federal University of Latin American Integration | Phase 1 / Phase 2 |
| Unknown | Efficacy of Acceptance and Commitment Therapy on Serum GDF-15 Levels in Older Adults With and Without Depressi NCT06195436 | Universidad de Colima | N/A |
| Recruiting | Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school NCT06668688 | Ludwig-Maximilians - University of Munich | — |
| Active Not Recruiting | Group Intervention for Interpersonal Skills NCT06170801 | Charite University, Berlin, Germany | N/A |
| Recruiting | Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles" NCT06668701 | Ludwig-Maximilians - University of Munich | — |
| Recruiting | Feasibility and Acceptability of Problem Management Plus (PM+) for Prisoners in the Netherlands - a Pilot RCT NCT05927987 | VU University of Amsterdam | N/A |
| Completed | Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults NCT06627400 | Kastamonu University | — |
| Not Yet Recruiting | Accelerated Intermittent Theta Burst Stimulation in Unipolar Versus Bipolar Depression NCT06422559 | Mansoura University | N/A |
| Active Not Recruiting | Intergenerational Study of War-Affected Youth NCT06440460 | Boston College | — |
| Completed | EVEN - Effects of VR on Empathy for Nature in Patients with Psychosis and Depressive Disorders NCT06446856 | Charite University, Berlin, Germany | — |
| Completed | Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, NCT06407154 | Universitätsklinikum Hamburg-Eppendorf | — |
| Active Not Recruiting | Mindfulness Engaged Neurostimulation for Depression NCT06399406 | University of California, San Diego | Phase 2 |
| Recruiting | M3VAS Validation in Polish Population NCT06412562 | Medical University of Gdansk | — |
| Not Yet Recruiting | Diagnosis of Depressive Disorder Malinger Using the Niacin Skin Response Test (NSRT) NCT06382532 | Air Force Military Medical University, China | — |
| Recruiting | Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness NCT05962879 | Massachusetts General Hospital | N/A |
| Completed | Culture and Well-being: Art as Prescription Therapy ("Art on Prescription") NCT06361667 | KAVADIA ELENI | N/A |
| Completed | Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State NCT06133309 | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | N/A |
| Recruiting | Improving Outcomes in Depression in Primary Care in a Low Resource Setting NCT05944926 | Harvard Medical School (HMS and HSDM) | Phase 3 |
| Recruiting | Association of Peripheral Immune Cells With Antidepressant Treatment Response NCT06182722 | Shanghai Mental Health Center | — |
| Recruiting | Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders NCT07295652 | Centre Hospitalier St Anne | N/A |
| Completed | Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME) NCT06091163 | University of Oxford | N/A |
| Enrolling By Invitation | Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study NCT07363980 | Ellen Margrethe Hauge | — |
| Unknown | AI to Support Mental Health Case Management Providers NCT06280170 | Eleos Health | N/A |
| Completed | Psilocybin in Alcohol Use Disorder With Comorbid Depression NCT06235411 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Withdrawn | Mood Disorders in Head and Neck Cancer Patients NCT04977271 | University of Alabama at Birmingham | Phase 4 |
| Enrolling By Invitation | Financial Incentives for Veteran Therapy Completion NCT06234371 | Christopher Cronin | N/A |
| Not Yet Recruiting | Ketogenic Diet for Depression NCT06105762 | University Psychiatric Clinics Basel | N/A |
| Recruiting | RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS NCT06143293 | University of Minnesota | N/A |
| Enrolling By Invitation | Pediatric Behavioral Health Integrated Care: Indiana Statewide Strategic Plan to Address the Growing Mental He NCT07216638 | Indiana University | — |
| Active Not Recruiting | Feasibility of Process-based Therapy in a Naturalistic Setting NCT06530888 | Goethe University | N/A |
| Recruiting | An Innovative Master Platform for Clinical Trials in Mood Disorders NCT06408012 | St. Joseph's Healthcare Hamilton | — |
| Recruiting | Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change NCT06671158 | Carilion Clinic | N/A |
| Recruiting | Music Therapy for Adolescents with Emotional Difficulties NCT06733883 | Oslo University Hospital | N/A |
| Completed | Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression NCT06094907 | Universidade Federal do Rio Grande do Norte | Phase 2 |
| Unknown | Augmentation of Interpersonal Psychotherapy With High-Definition Transcranial Direct Current Stimulation for A NCT06061653 | First Affiliated Hospital of Zhejiang University | N/A |
| Recruiting | Unified Protocol: Community Connections NCT06038721 | University of Miami | N/A |
| Recruiting | Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality NCT05925322 | Weill Medical College of Cornell University | N/A |
| Unknown | OcupApp: Occupational Self-analysis Intervention Through an Mobile Application NCT05867823 | University of Malaga | N/A |
| Recruiting | Study the Efficacy and Safety of the INtegral Cognitive REMediation Program (INCREM) for Depression NCT06590025 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Phase 3 |
| Recruiting | Adaptation of Individual Dialectical Behavior Therapy Intervention for Transdiagnostic Treatment of Emotional NCT05989451 | Mackay Memorial Hospital | N/A |
| Completed | OptimizeD Pilot Study NCT06153004 | Harvard Medical School (HMS and HSDM) | Phase 3 |
| Terminated | Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study NCT05961163 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | Oxford Social Movement Activation Study NCT05963581 | University of Oxford | N/A |
| Completed | Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depr NCT05792540 | Tanta University | Phase 2 |
| Recruiting | Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes NCT05543083 | Colorado State University | N/A |
| Unknown | Electroconvulsive Therapy and Concomitant Lithium in Depressive Disorder: A Pilot Study NCT05923476 | Melbourne Health | EARLY_Phase 1 |
| Completed | Precision Mental Health in Diabetes - Subtypes of Mental Health, Trajectories, and Patterns With Glycaemic Con NCT05548699 | Forschungsinstitut der Diabetes Akademie Mergentheim | — |
| Recruiting | Depressed Mood Improvement Through Nicotine Dosing 3 NCT05746273 | Vanderbilt University Medical Center | Phase 2 |
| Active Not Recruiting | Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension NCT05746546 | Vanderbilt University Medical Center | Phase 2 |
| Unknown | Assessment of Sleep Quality and Mental Health After Using Meditation NCT05812443 | Federal University of Minas Gerais | N/A |
| Recruiting | The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects NCT05786066 | Yale University | Phase 2 |
| Completed | The Relationship Between Fibromyalgia Syndrome Parameters With Disease-Pain Severity and the Quality Of Life NCT05850442 | Umraniye Education and Research Hospital | — |
| Unknown | Influence of Oxycodone on Individuals Taking an SSRI NCT05730062 | Leiden University Medical Center | Phase 1 |
| Recruiting | Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response NCT06630065 | Centre Hospitalier St Anne | N/A |
| Completed | Study of Virtual Reality-based Medical Device for Patients with Depressive Disorder NCT05701345 | Omni C&S | N/A |
| Completed | Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD) NCT05686408 | Tonix Pharmaceuticals, Inc. | Phase 2 |
| Unknown | UP in Blended Format for Transdiagnostic Treatment of Emotional Disorders in the Spanish National Health Syste NCT04304911 | Instituto de Investigación Sanitaria Aragón | N/A |
| Unknown | Effectiveness of Traditional and Computerized Versions of Super Skills for Life in Children NCT05574491 | Universidad Miguel Hernandez de Elche | N/A |
| Recruiting | Whole Health in VA Mental Health: Omnis Salutis NCT05400252 | VA Office of Research and Development | N/A |
| Unknown | Development and Application of Comprehensive Intervention Techniques for Adolescent Depression NCT05945342 | First Affiliated Hospital of Zhejiang University | N/A |
| Terminated | Digital Therapeutic for Adolescent Depressive Symptoms in Hematology, Oncology, and Weight Management NCT05351866 | Limbix Health, Inc. | N/A |
| Unknown | Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults NCT05976659 | Hebrew SeniorLife | N/A |
| Completed | Empower@Home:Connected - Feasibility and Preliminary Effect Study NCT05732740 | University of Michigan | N/A |
| Unknown | Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) in People With Post NCT05581277 | Instituto de Investigación Sanitaria Aragón | N/A |
| Unknown | Work-Health-Life-Balance - Mental Resilience, Stability & Healthy Nutrition NCT05489835 | Medical University of Graz | — |
| Completed | The Preliminary Effects of Empower@Home NCT05593276 | University of Michigan | N/A |
| Recruiting | Ketamine Treatment Plans for Chronic Conditions NCT06038409 | RIVER Foundation | — |
| Unknown | Development of a Model for Shared Care in the Interface Between General Practice and Mental Health Care NCT05172375 | Psychiatric Research Unit, Region Zealand, Denmark | N/A |
| Unknown | Effect of HD-tDCS Assisted ECT for Depression Disorder NCT06109480 | Anhui Medical University | N/A |
| Completed | Group Version of the UP-A in a Spanish Day Hospital for Adolescents. NCT06894394 | Universidad Nacional de Educación a Distancia | N/A |
| Withdrawn | Effect of SSRIs on Response to Psilocybin Therapy NCT05594667 | Cybin Therapeutics Inc. | Phase 2 |
| Unknown | Self-administered Acupressure for Depression NCT05631184 | The Hong Kong Polytechnic University | N/A |
| Completed | Group Version of the UP-A in a Spanish Public Mental Health Setting. NCT06894368 | Universidad Nacional de Educación a Distancia | N/A |
| Completed | Bridging the Gap From Postpartum to Primary Care NCT05543265 | Massachusetts General Hospital | N/A |
| Completed | A Treatment for Depression Via a Gamified Mobile Phone Application Based on a New Cognitive Model NCT05685758 | Hedonia Ltd | N/A |
| Unknown | Development and Application of Intelligent Diagnosis and Treatment Norms for Children and Adolescents With Men NCT06155201 | Chen Li | N/A |
| Unknown | A Clinical Study on the Effects of Inhalation of Volatile Oil of Cang-Ai Via the Nose on Patients With Depress NCT05251779 | Jieqiong Cui | EARLY_Phase 1 |
| Not Yet Recruiting | Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Re NCT05547711 | Julia Eder | N/A |
| Completed | Remote Coaching for Supporting the Implementation of Depression Care in Primary Care in Rural India NCT05264792 | Harvard Medical School (HMS and HSDM) | N/A |
| Recruiting | Big Feelings: A Study on Children's Emotions in Therapy NCT05637320 | University of Guelph | N/A |
| Completed | Feasibility of a Group Blended Transdiagnostic CBT Protocol for Emotional Disorders NCT04008576 | Universitat Jaume I | N/A |
| Recruiting | Combining Antidepressants and Attention Bias Modification in Depression NCT05503966 | University of Oslo | N/A |
| Completed | Intervention Effect of High Definition Transcranial Alternating Current Stimulation (HD-tACS) on Depressive Di NCT05932706 | Anhui Medical University | N/A |
| Completed | Anxiety and / or Depressive Disorders in a Population of French Airline Pilot NCT05446519 | Centre Hospitalier Universitaire de Nice | — |
| Completed | Sleep Signal Analysis for Current Major Depressive Episode (SAMDE) NCT05708222 | Medibio Limited | — |
| Withdrawn | Preoperative Ketamine and Perioperative Depression NCT04220125 | Northwestern University | Phase 4 |
| Terminated | Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology NCT05461599 | Limbix Health, Inc. | N/A |
| Completed | Trial of Transcranial Photobiomodulation for Depression With PET and EEG Outcomes NCT06934135 | NeuroThera DE | N/A |
| Unknown | The Efficacy of Acupressure Therapy on Patient With Depression NCT05423405 | University Psychiatric Clinics Basel | N/A |
| Completed | Self-guided Treatment for Adolescents Navigating Depression NCT05462652 | Limbix Health, Inc. | N/A |
| Completed | Effect of Probiotic Supplement on Improvement of Depressive Symptoms in Patients With Substance-Induced Depres NCT06790823 | Shiraz University of Medical Sciences | Phase 1 / Phase 2 |
| Completed | CBTpro: Scaling up CBT for Psychosis Using Simulated Patients and Spoken Language Technologies NCT05127837 | University of Washington | N/A |
| Completed | Effects of 12-week Exercise Program on Sleep Quality and Fear of Death in Geriatric Individuals NCT05418283 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | N/A |
| Unknown | Microbiotherapy in Characterized Depressive Disorder NCT05280015 | Centre Hospitalier Universitaire de Besancon | Phase 2 |
| Completed | A Single Group Study of Empower@Home-an Internet Cognitive Behavioral Therapy Intervention NCT05384704 | University of Michigan | N/A |
| Recruiting | Development of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient NCT06182787 | Sheba Medical Center | — |
| Unknown | Efficacy of Gamified Cognitive Control Training Using de:)Press on Depression Severity add-on to Treatment as NCT05385614 | University Hospital Tuebingen | N/A |
| Recruiting | OSU6162 as add-on in SSRI/SNRI-resistant Depression NCT05641623 | Göteborg University | Phase 2 |
| Terminated | Ketamine for OUD and Comorbid Depression (OUDCD) NCT05051449 | University of Maryland, Baltimore | Phase 1 |
| Unknown | Implementation of a Psychological Online Intervention for Low to Moderate Depression in Primary Health Care NCT05294614 | Universitat Jaume I | N/A |
| Completed | Feasibility of a Culturally Adapted Emotional-Behavioral Prevention Program for American Indian Children NCT05371665 | Montana State University | N/A |
| Unknown | Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive NCT05266560 | First Affiliated Hospital of Chongqing Medical University | EARLY_Phase 1 |
| Unknown | Home-based Transcranial Electrical Stimulation (TES) in Patients With Chronic Tinnitus NCT05189587 | Seoul National University Hospital | N/A |
| Unknown | Multimodal Biomarkers of Electroconvulsive Therapy in Severe and Treatment-resistant Depression NCT05463562 | Max-Planck-Institute of Psychiatry | — |
| Completed | A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of DGX-001 NCT05121831 | Digestome Therapeutics | Phase 1 |
| Completed | Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT) NCT04282915 | George Washington University | N/A |
| Terminated | Reducing Suicide Risk in Older Veterans Using Problem Solving Therapy NCT04763330 | VA Office of Research and Development | N/A |
| Unknown | Research on the Biological Mechanism of the Efficacy of Psychotherapy for Depression Based on the fNIRS NCT05927129 | First Affiliated Hospital of Zhejiang University | N/A |
| Unknown | Efficacy of the Unified Protocol for the Transdiagnostic Treatment (UP-A; Ehrenreich-May et al., 2018) for Ado NCT05322642 | Eduardo Fonseca Pedrero | N/A |
| Completed | Family Promoting Positive Emotions Pilot Study NCT05223842 | Vanderbilt University | N/A |
| Completed | Synaptic Imaging and Network Activity in Treatment Resistant Depression NCT05870501 | King's College London | N/A |
| Terminated | Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing NCT04650217 | New York State Psychiatric Institute | Phase 4 |
| Recruiting | Prediction of ECT Treatment Response and Reduction of Cognitive Side-effects Using EEG and Rivastigmine NCT05768126 | UMC Utrecht | Phase 4 |
| Completed | Digital Intervention to Treat Anxiety and Depression Among Persons Receiving Treatment for Opioid Use Disorder NCT05047627 | Trustees of Dartmouth College | N/A |
| Active Not Recruiting | Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Del NCT04777006 | RAND | Phase 4 |
| Completed | Behavioral Activation Teletherapy to Increase Physical Activity NCT04990401 | University of Texas Southwestern Medical Center | N/A |
| Completed | Improving Depressive Symptoms Through Personalised Exercise and Activation NCT04857944 | Hospital del Mar Research Institute (IMIM) | N/A |
| Completed | Exploring Medically Perceived Benefits, Use and Interest in Psychedelics and Cannabinoids NCT04965740 | Empower Research Inc | — |
| Completed | EVALUATION OF BLOOD BIOMARKER-BASED DIAGNOSTIC AID IN OUTPATIENTS SUFFERING FROM DEPRESSION NCT06369805 | Les Toises - Psychiatry and Psychotherapy Center | — |
| Recruiting | Reward Processing and Depressive Subtypes: Identifying Neural Biotypes NCT06080646 | San Francisco Veterans Affairs Medical Center | — |
| Active Not Recruiting | Establish a Specific Cohort Database for Depressive Disorders NCT05095662 | Shanghai Mental Health Center | — |
| Completed | Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder NCT06165445 | The National Brain Mapping Laboratory (NBML) | N/A |
| Completed | Post-traumatic Stress, Signs of Depression and Burnout Syndrome Among Nursing Home Staff in Occitanie During t NCT04916275 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Suicide Prevention Among Recipients of Care NCT04893447 | St. Luke's Health System, Boise, Idaho | N/A |
| Unknown | Music After Stroke To Enhance Rehabilitation NCT04441515 | Pace University | N/A |
| Completed | Systematic Use of Telepsychiatry for Outpatients NCT05516238 | Psychiatric Research Unit, Region Zealand, Denmark | N/A |
| Active Not Recruiting | Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression NCT04747340 | Umeå University | N/A |
| Completed | Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders NCT05120232 | Boston University Charles River Campus | N/A |
| Unknown | Adjunctive Bright Light Therapy for Patients With Depression NCT04633707 | Guangzhou Psychiatric Hospital | N/A |
| Terminated | Treating Adolescents With CBT and OBH NCT04760938 | University of New Hampshire | N/A |
| Completed | Evaluation of a Website to Improve Depression Literacy in Parents of Adolescents With Depression NCT05335564 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Evaluation of a Website to Improve Depression Literacy in Parents of Healthy Adolescents NCT05326178 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Evaluation of a Website to Improve Depression Literacy in Adoldescents NCT05300217 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Web-based Self-help Intervention for Adolescents With Acute or Remitted Major Depressive Disorder NCT04994470 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Evaluation of a Website to Improve Depression Literacy in Adolescents With Depression NCT05300204 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Depressive Disorde NCT05286645 | Anhui Medical University | N/A |
| Unknown | Research on Voice Intelligent Monitoring Technology for Early Warning of Recurrence of Depression Disorder NCT04685083 | Shanghai Mental Health Center | — |
| Unknown | The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameter NCT04756544 | Medical University of Lodz | Phase 3 |
| Completed | Memory Changes in Patients With Major Depression Disorder Treated With ECT NCT03915821 | Assiut University | N/A |
| Completed | Depressed Mood Improvement Through Nicotine Dosing 2 NCT04433767 | Vanderbilt University Medical Center | Phase 2 |
| Unknown | Efficacy and Safety of Peropirone Hydrochloride Tablets in the Treatment of Adolescent Bipolar Disorder Depres NCT04826510 | Shanghai Mental Health Center | Phase 4 |
| Completed | The Danish Neuropsychological Study of the Adverse Effects of ECT NCT04160286 | University of Copenhagen | — |
| Recruiting | PROSPECTIVE EVALUATION OF BLOOD BIOMARKERS AS AN AID TO DIAGNOSTIC AND TREATMENT IN DRUG-NAIVE PATIENTS WITH D NCT06369792 | Les Toises - Psychiatry and Psychotherapy Center | — |
| Unknown | Brief Transdiagnostic Group CBT for Adolescents With Internalizing Problems: A Randomized Waitlist Controlled NCT04716777 | University of Iceland | N/A |
| Completed | Ascertaining Diagnosis Classification With Elicited Speech NCT05601063 | Northwell Health | — |
| Recruiting | Transcranial Direct Current Stimulation for Depression NCT06187454 | Taipei Veterans General Hospital, Taiwan | N/A |
| Unknown | Psychological Impact of Admission With Covid-19 During the SARS-CoV-2 Pandemic: Naturalistic Cohort Study With NCT04449627 | Royal Free Hospital NHS Foundation Trust | — |
| Enrolling By Invitation | Youth Depression and Suicide Research Network NCT04572321 | University of Texas Southwestern Medical Center | — |
| Completed | Effects of Non-drug Therapy on Cognitive Function in Healthy Individuals and Patients With First Episode Depre NCT04503343 | Central South University | N/A |
| Completed | A Single-center Randomized Controlled Study on the Effect of Pharmacogenomics Trial on Clinical Efficacy in Pa NCT05959187 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | A 12-weeks Study to Evaluate Sulforaphane in the Treatment of Depression NCT04246905 | Central South University | Phase 2 |
| Unknown | Mindfulness Based Emotion Regulation Therapy in the Treatment of Depressive Rumination NCT04560192 | University Hospital Tuebingen | N/A |
| Completed | Delivering ICBT to Address Mental Health Challenges in Correctional Officers and Other Public Safety Personnel NCT04666974 | Dr. Nazanin Alavi | N/A |
| Completed | Self and Body-esteem in Socio-professional Rehabilitation NCT04436757 | Hôpital le Vinatier | N/A |
| Completed | Augmentation of Depression Treatment by Gamified Network Retraining NCT04400162 | University Hospital Tuebingen | N/A |
| Unknown | Prediction on the Recurrence of Manic and Depressive Episodes in Bipolar Disorder NCT05828056 | National Taiwan University Hospital | — |
| Completed | Message-Based Psychotherapy and Digital Treatment Sequences for Depression NCT04513080 | Talkspace | N/A |
| Completed | Comparison Study of the Different Abbreviated Versions of the Geriatric Depression Scale NCT04180683 | Rsocialform - Geriatria, Lda | — |
| Completed | Investigation of the Effects of Medium Cut-off Dialyzers Versus High-Flux Dialyzers on Clinical and Laboratory NCT05698420 | Sanliurfa Mehmet Akif Inan Education and Research Hospital | — |
| Completed | A Multi-component Intervention to Improve Medication Adherence in People With Depressive Disorders NCT03668457 | Servicio Canario de Salud | N/A |
| Active Not Recruiting | StayFine: Personalised Relapse Prevention of Anxiety and Mood Disorders in Youths NCT05551468 | Ggz Oost Brabant | N/A |
| Completed | Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making NCT04635748 | Mclean Hospital | — |
| Completed | Internet Transdiagnostic-CBT for Anxiety and Depression in Adolescents NCT04182061 | Universidad Nacional de Educación a Distancia | N/A |
| Unknown | Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive Disorder NCT04124276 | Guangzhou Psychiatric Hospital | N/A |
| Completed | Transdiagnostic Treatment Personalization NCT04584879 | Shannon E. Sauer-Zavala | N/A |
| Active Not Recruiting | Imaging to Improve Brain Stimulation NCT04016402 | VA Office of Research and Development | — |
| Unknown | Post-traumatic Stress Injuries Among Paramedics and Emergency Dispatchers NCT04202042 | Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal | N/A |
| Unknown | Citalopram and Stress Reactivity NCT04161209 | University of Oxford | N/A |
| Unknown | Citalopram and Self Emotional Processing NCT04169230 | University of Oxford | N/A |
| Completed | Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations NCT04162847 | Washington University School of Medicine | N/A |
| Unknown | Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions NCT04066985 | Child Mind Institute | N/A |
| Completed | Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong NCT04091139 | Chinese University of Hong Kong | Phase 2 / Phase 3 |
| Unknown | Population Screening Using Smartphone in Milpa Alta NCT04067063 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | — |
| Unknown | Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA NCT04067076 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | — |
| Unknown | A Clinical Trial of Fluvoxamine for Melancholia NCT04160377 | Lingjiang Li | Phase 2 |
| Unknown | Does Antidepressant Use Blunt Adaptations to Exercise? NCT03934723 | California State University, San Marcos | N/A |
| Completed | Light Therapy on Major Depression Disorder NCT03941301 | Mackay Memorial Hospital | N/A |
| Completed | Peer-led Group Intervention for Coping With Disaster NCT03907995 | Baylor College of Medicine | N/A |
| Completed | Nitrous Oxide for Major Depressive Disorder NCT03932825 | Lingjiang Li | Phase 2 |
| Completed | Electronic Communication Augmented Mental Health Care NCT03925038 | Johns Hopkins University | N/A |
| Unknown | Repetitive Transcranial Magnetic Stimulation Trajectory of Outcomes Study NCT04376697 | University Health Network, Toronto | N/A |
| Unknown | Theta-Burst Stimulation in Major Depressive Episodes With Mixed Characteristics. NCT04123301 | University of Sao Paulo | N/A |
| Completed | Mindful Breathing and tDCS for Depression NCT03897699 | University of Minnesota | N/A |
| Unknown | Applied Social Neuroscience: the Building Resilience Among Women Project NCT03623555 | Ximena Goldberg | — |
| Completed | Effects of Behavioural Activation on Emotional Cognition and Mood NCT03995186 | University of Oxford | N/A |
| Completed | Mindfulness and Relaxation Interventions in Individual Psychotherapies for Children and Adolescents NCT04034576 | Heidelberg University | N/A |
| Completed | The Police-Mental Health Linkage System NCT03740139 | Columbia University | N/A |
| Completed | Monitoring Telemedicine Platform in Patients With Anxiety Symptoms and Alcohol Use Disorder NCT03991650 | humanITcare | — |
| Completed | Manual-based Art Therapy for Adolescents With Depression NCT04603235 | Vastra Gotaland Region | N/A |
| Unknown | Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression T NCT03491696 | Centre Hospitalier Rouffach | Phase 4 |
| Unknown | Cerebral Neuroinflammation During Major Depressive Episode NCT03314155 | University Hospital, Toulouse | N/A |
| Terminated | Salicylic Augmentation in Depression NCT03152409 | Jessica Harder | Phase 2 |
| Completed | RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood NCT03646539 | Stanford University | N/A |
| Completed | Impact of Exercise on "Invisible" Symptoms and Quality of Life in Multiple Sclerosis Individuals NCT03768830 | University of Rijeka | N/A |
| Completed | Dignity Therapy for Patients With Early Dementia and Their Family NCT03692988 | University of Zurich | N/A |
| Unknown | Auricular Concha Electro-acupuncture for the Treatment of Depression NCT03607331 | China Academy of Chinese Medical Sciences | EARLY_Phase 1 |
| Completed | Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients NCT03674138 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Completed | Internet-based Cognitive Behavioral Therapy for Adolescents With Sleep Problems- a Feasibility Trial NCT04616157 | Karolinska Institutet | N/A |
| Completed | Meditation Based Lifestyle Modification in Depression NCT03652220 | Diakonie Kliniken Zschadraß | N/A |
| Active Not Recruiting | Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents NCT03626103 | Rhode Island Hospital | N/A |
| Unknown | Resting-state Functional Connectivity Throughout a Course of iTBS in Major Depression NCT03944213 | University Hospital, Bonn | — |
| Completed | Collaborative and Stepped Care in Mental Health (COMET) NCT03226743 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Unknown | Study of Addiction Criteria in the Elderly NCT03509077 | University Hospital, Toulouse | — |
| Unknown | Anxiety and Depression in COPD; Prevalence, Detection and Prognosis NCT04427579 | University Hospital, Akershus | — |
| Completed | Effects of Seven Day Prucalopride Administration in Healthy Volunteers NCT03572790 | University of Oxford | N/A |
| Unknown | Mobile Health For Pacemaker Patientes NCT04582058 | InCor Heart Institute | N/A |
| Terminated | Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder NCT03537547 | Washington University School of Medicine | Phase 4 |
| Completed | Super Skills for Life Effectiveness in Clinical Settings NCT05482724 | Universidad Miguel Hernandez de Elche | N/A |
| Completed | Bioavailability Study of Amitriptyline Hydrochloride Tablets NCT03646526 | First Affiliated Hospital of Zhejiang University | Phase 1 |
| Unknown | Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant Depression NCT04234776 | University of Sao Paulo | Phase 4 |
| Completed | An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression NCT03222570 | University of Minnesota | Phase 2 |
| Withdrawn | Transcranial Direct Current Stimulation (tDCS) in Children and Adolescents With Epilepsy and Depression NCT03368469 | Mayo Clinic | N/A |
| Terminated | A Study of Duloxetine (LY248686) in the Treatment of Japanese Children and Adolescents With Depressive Disorde NCT03395353 | Shionogi | Phase 3 |
| Completed | Study of Mind-Body Skills Groups for Adolescents With Depression in Primary Care NCT03363750 | Indiana University | N/A |
| Completed | Promoting Attachment Through Healing NCT03536442 | Western University, Canada | — |
| Completed | A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression NCT03460756 | Marinus Pharmaceuticals | Phase 2 |
| Completed | Neutral and Positive Attention Bias Modification Training for Young Adults With Depressive Symptoms NCT03971942 | Hunan Normal University | N/A |
| Active Not Recruiting | Cooperation for Primary Care Patients on Sick Leave for CMD: Care Manager and Workplace Intervention - CO-WORK NCT03250026 | Göteborg University | N/A |
| Completed | A Study of Duloxetine (LY248686) in Japanese Children and Adolescents With Depressive Disorder NCT03315793 | Shionogi | Phase 3 |
| Unknown | Comorbid Mental Disease and Heart Disease in Men NCT03354351 | Universite de Moncton | — |
| Terminated | Intermittent Theta Burst for the Treatment of Alcohol Use Disorders in Veterans NCT03291431 | Stanford University | N/A |
| Completed | Adaptive Design Study of NEST sTMS in Subjects With Major Depressive Disorder NCT03288714 | Wave Neuroscience | N/A |
| Completed | Fertility Life Counselling Aid- FeLiCiA NCT03348865 | Andrew Weeks MD MRCOG | N/A |
| Unknown | Effectiveness of a Psychoeducational Group Intervention in Patients With Depression and Physical Comorbidity NCT03243799 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Completed | Super Skills for Life Effectiveness in the Online Modality NCT05589090 | Universidad Miguel Hernandez de Elche | N/A |
| Completed | Telephone-administered Relapse Prevention for Depression NCT03219879 | University of Zurich | N/A |
| Completed | Study to Treat Major Depressive Disorder With a New Medication NCT03043560 | James Murrough | Phase 2 |
| Completed | Palliative Care and Quality of Life in Idiopathic Pulmonary Fibrosis NCT03981406 | University of Minnesota | N/A |
| Terminated | Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine NCT02969876 | Massachusetts General Hospital | Phase 4 |
| Completed | Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients NCT03287986 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Exploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI Study NCT03040388 | University of Copenhagen | — |
| Unknown | Multi-Dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Base NCT03219008 | Shanghai Mental Health Center | Phase 4 |
| Completed | A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression NCT03228394 | Marinus Pharmaceuticals | Phase 2 |
| Completed | Melatonin Decreases Eye Pressure in Normotensive Patients NCT03193112 | Kahramanmaras Sutcu Imam University | — |
| Unknown | Effectiveness & Cost-effectiveness of Internet-delivered Interventions for Depression and Anxiety Disorders in NCT03188575 | Silver Cloud Health | N/A |
| Completed | Novel Neural Circuit Biomarkers of Major Depression Response to CCBT NCT03096886 | University of Pennsylvania | N/A |
| Completed | Virtual Reality Job Interview Training in Severe Mental Illness NCT03049813 | University of Michigan | N/A |
| Unknown | Effects of Transcranial Direct Current Stimulation (tDCS) on Individuals With Prader-Willi Syndrome NCT03324906 | Federal University of São Paulo | N/A |
| Completed | The Effect of Transcranial Direct Current Stimulation on Cognitive Side Effects of Electroconvulsive Therapy NCT02897843 | Northwell Health | N/A |
| Terminated | Internet-delivered Treatments for Depression and Anxiety in Primary Care (SUMMA) NCT03068676 | Silver Cloud Health | N/A |
| Completed | Effects of Acute Prucalopride Administration in Healthy Volunteers NCT03863366 | University of Oxford | N/A |
| Completed | EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy NCT02676882 | Massachusetts General Hospital | N/A |
| Completed | Screening for Depression and Anxiety in Patients With Heart Disease NCT03203395 | Diakonhjemmet Hospital | N/A |
| Withdrawn | Evaluating the Efficacy of Magnetic Seizure Therapy in Treatment Resistant Depression. NCT01748708 | Centre for Addiction and Mental Health | N/A |
| Completed | Gaze Contingent Feedback in Major Depressive Disorder (MDD) NCT02945735 | Tel Aviv University | N/A |
| Unknown | Burn Out Among Medical Family Doctors NCT04242862 | University Hospital, Clermont-Ferrand | — |
| Completed | Testing Psychosocial Treatment Planning Methods for Youth Anxiety and Depression NCT03610373 | Boston University Charles River Campus | N/A |
| Unknown | Effectiveness of a Brief Psychological Mindfulness Based Intervention for the Treatment of Depression in Prima NCT03034343 | Universitat Jaume I | N/A |
| Unknown | Interpersonal Counseling (IPC) for Treatment of Depression in Adolescents NCT03001245 | Hospital District of Helsinki and Uusimaa | N/A |
| Completed | Effectiveness and Underlying Mechanisms of Applied Relaxation as Indicated Preventive Intervention NCT03311529 | Technische Universität Dresden | N/A |