Clinical Trials Directory

Trials / Completed

CompletedNCT03572790

Effects of Seven Day Prucalopride Administration in Healthy Volunteers

The Effect of Seven Day Prucalopride Administration on Emotional Processing in Healthy Volunteers

Status
Completed
Phase
N/A
Study type
Interventional
Enrollment
50 (actual)
Sponsor
University of Oxford · Academic / Other
Sex
All
Age
18 Years – 40 Years
Healthy volunteers
Accepted

Summary

This study will investigate whether seven days administration of the serotonin receptor subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and neural activity in healthy volunteers, compared to placebo administration. Using an experimental medicine approach, the effects of prucalopride on cognitive biomarkers of antidepressant action will be characterised. In a double-blind design, participants will be randomised to receive seven days administration of either prucalopride (1mg daily) or placebo. All participants will come for a Screening visit, Research Visit One (including an MRI scan) and Research Visit Two (including measures of emotional processing and non-emotional cognition). The primary study hypothesis is that seven-day prucalopride administration will have positive effects on emotional processing and reward sensitivity. A secondary hypothesis is that seven-day prucalopride administration will alter non-emotional cognition. Finally, the study will test the hypothesis that seven day prucalopride administration will alter neural activity during an emotional faces task and a memory task.

Conditions

Interventions

TypeNameDescription
DRUGPrucalopride1mg prucalopride capsule, once daily for seven days
OTHERPlaceboLactose placebo capsule, once daily for seven days

Timeline

Start date
2018-06-11
Primary completion
2019-05-17
Completion
2019-05-17
First posted
2018-06-28
Last updated
2022-11-18

Locations

1 site across 1 country: United Kingdom

Source: ClinicalTrials.gov record NCT03572790. Inclusion in this directory is not an endorsement.