Trials / Completed
CompletedNCT03932825
Nitrous Oxide for Major Depressive Disorder
A Clinical Trial of Nitrous Oxide for Treatment-Resistant Major Depressive Disorder
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 44 (actual)
- Sponsor
- Lingjiang Li · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
This study aims at investigating the persistence of antidepressant effect of Nitrous Oxide (N2O) for Treatment-Resistant Depression(TRD). The investigators also aim to assess the effect of N2O on the electroencephalograph, multimodal magnetic resonance imaging(MRI), blood cytokines, feces bacteria flora and neuropsychological performance in patients with TRD. The investigators further aim to identify the predictors of N2O's antidepressant effeect using the above techniques.
Conditions
- Depressive Disorder
- Major Depressive Disorder
- Treatment Resistant Depression
- Depressive Disorder, Major
- Depression
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Nitrous Oxide | An 1-hour session of inhaled nitrous oxide at concentrations of 50%. |
| DRUG | Placebo | An 1-hour session of mixed oxygen-air gas(inspired oxygen concentration \~50%) |
Timeline
- Start date
- 2019-04-01
- Primary completion
- 2021-03-31
- Completion
- 2021-03-31
- First posted
- 2019-05-01
- Last updated
- 2021-04-08
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03932825. Inclusion in this directory is not an endorsement.