Clinical Trials Directory

Trials / Conditions / Depressive Disorder, Major

Depressive Disorder, Major

349 registered clinical trials studyying Depressive Disorder, Major41 currently recruiting.

StatusTrialSponsorPhase
Not Yet RecruitingA Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorde
NCT06689787
VA Office of Research and DevelopmentN/A
Not Yet RecruitingAcupuncture and Escitalopram for Treating Major Depression Clinical Study
NCT05901571
Shanghai 7th People's HospitalN/A
RecruitingA Study of Brenipatide in Adult Participants With Major Depressive Disorder
NCT07412756
Eli Lilly and CompanyPhase 3
RecruitingA Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disord
NCT07227454
Janssen Research & Development, LLCPhase 3
WithdrawnTranscranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive
NCT05194332
The University of Texas Health Science Center, HoustonN/A
RecruitingA Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants
NCT07258485
Janssen Research & Development, LLC
RecruitingThe Motor Activity - Subjective Energy (MASE) Project
NCT07059234
University of BernN/A
Not Yet RecruitingA Study on Functional Connectome and rTMS Intervention of Cognitive Flexibility Impairment in Patients With Ma
NCT07161492
Second Xiangya Hospital of Central South UniversityN/A
RecruitingSelf Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
NCT06982820
GrayMatters Health Ltd.N/A
Not Yet RecruitingElectrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
NCT06470035
Neurovalens Ltd.N/A
RecruitingDosing rTMS for Depression Post-SCI
NCT05553353
VA Office of Research and DevelopmentN/A
RecruitingClinical Efficacy, Safety, and Applicability of Home-based Bright Light Therapy in Outpatient Adolescents With
NCT06913309
Peking University Sixth HospitalN/A
RecruitingRoflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients
NCT06860958
Tanta UniversityPhase 3
RecruitingPharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipul
NCT05232032
Mclean HospitalPhase 2
RecruitingCognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
NCT06136546
Massachusetts General HospitalPhase 2
WithdrawnPilot Study: Investigating Mood Changes After Slow-wave Enhancement
NCT05146427
University of PennsylvaniaN/A
RecruitingA Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
NCT06785012
Janssen Research & Development, LLCPhase 2
Enrolling By InvitationPrecision Care for Major Depressive Disorder
NCT06580041
University of California, San FranciscoPhase 4
RecruitingInvestigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Trea
NCT06511908
National Institute of Mental Health (NIMH)Phase 2
RecruitingThe Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Majo
NCT06621394
University Hospital TuebingenN/A
CompletedA Study to Test Different Doses of BI 1569912 in People With Depression
NCT06558344
Boehringer IngelheimPhase 2
TerminatedA Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Maj
NCT06635135
Janssen Research & Development, LLCPhase 3
RecruitingComparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression
NCT06152705
The Royal Ottawa Mental Health CentreN/A
Not Yet RecruitingTizanidine vs. Zolpidem in Primary Insomnia: A Randomized Trial
NCT06303076
Sultan Qaboos UniversityPhase 4
Not Yet RecruitingEffectiveness of Cariprazine Monotherapy for Treatment of Major Depressive Disorder
NCT05933538
Sultan Qaboos UniversityPhase 4
RecruitingComparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
NCT06528938
The Royal Ottawa Mental Health CentreN/A
Not Yet RecruitingbWell-D Pilot Randomized Controlled Trial
NCT06546917
University of British ColumbiaN/A
RecruitingPhase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive
NCT06559306
Janssen Research & Development, LLCPhase 3
TerminatedA Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) W
NCT06514742
Janssen Research & Development, LLCPhase 3
TerminatedBehavioural Activation Therapy and Esketamine for Resistant Depression
NCT06431386
The Royal's Institute of Mental Health ResearchN/A
Enrolling By InvitationNon-invasive Vagus Nerve Stimulation as a Tool to Modulate Stomach-Brain Coupling in Depression
NCT06389175
University of BonnN/A
RecruitingPeer-led Intervention for Individuals With Major Depression.
NCT06398561
University of the Balearic IslandsN/A
WithdrawnA Study of Participants With Moderate or Severe Major Depressive Disorder (MDD) Requiring Urgent Symptom Contr
NCT04829669
Janssen-Cilag Ltd.
CompletedA Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive Medicine
NCT06280235
Boehringer IngelheimPhase 2
Active Not RecruitingPsilocybin for Major Depressive Disorder (MDD)
NCT06308653
Usona InstitutePhase 3
RecruitingThe Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression
NCT06398496
University College CorkN/A
RecruitingEffectiveness of an Ecological Momentary Emotion Regulation Intervention
NCT06311136
Heidelberg UniversityN/A
TerminatedModulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
NCT06219681
Laureate Institute for Brain Research, Inc.N/A
Enrolling By InvitationNeuroimaging Study for Decoding Emotional States and Identifying Neural Circuits to Disengage From Negative Th
NCT06254144
Laureate Institute for Brain Research, Inc.
RecruitingThe Effect of Mindfulness-Based Psychoeducation
NCT06417619
University of GaziantepN/A
RecruitingInMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
NCT06005194
University of WashingtonN/A
UnknownTranscranial Magnetic Stimulation in Patients With Depression and Non-suicidal Self-injury
NCT06110585
Brain Institute of Rio Grande do SulN/A
WithdrawnVA Aripiprazole vs Esketamine for Treatment Resistant Depression
NCT05554627
VA Office of Research and DevelopmentPhase 4
RecruitingPsychoeducational Intervention for Families With a Member Affected by Major Depression
NCT05988333
University of Campania Luigi VanvitelliN/A
RecruitingAlpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine
NCT05915013
Yale UniversityPhase 1
CompletedCannabinoids as a Treatment for Insomnia in Major Depression
NCT05041647
St. Joseph's Healthcare HamiltonPhase 2
RecruitingDopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation
NCT05909267
Charite University, Berlin, GermanyN/A
Active Not RecruitingIndividualized Functional Connectivity Targeting in aiTBS for Depression
NCT05680727
Brigham and Women's HospitalPhase 2
CompletedThe Feasibility, Usability and Satisfaction of an Online Tool for Perinatal Mental Health Problems
NCT06035159
University Hospital, GhentN/A
CompletedBrain Network Dynamics of Depression During Esketamine Treatment
NCT06012916
University of North Carolina, Chapel Hill
Active Not RecruitingA Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current
NCT05841030
Janssen Research & Development, LLC
UnknownAltering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
NCT06320028
University of ArizonaPhase 1 / Phase 2
CompletedStudy to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
NCT05686408
Tonix Pharmaceuticals, Inc.Phase 2
CompletedA Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to
NCT05550532
Janssen Research & Development, LLCPhase 3
RecruitingPrediction of Antidepressant Effects of Electroconvulsive Therapy
NCT05630469
Medical University of Vienna
RecruitingAcceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Ment
NCT05491538
VA Office of Research and DevelopmentN/A
UnknownThe Role of Neuromodulation Technique In Depression Disorder
NCT05047159
Shanghai Mental Health CenterN/A
Active Not RecruitingTreating Immuno-metabolic Depression With Anti-inflammatory Drugs
NCT05415397
Amsterdam UMC, location VUmcPhase 3
TerminatedA Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)
NCT05518149
Janssen Research & Development, LLCPhase 3
UnknownClinical Study of Biomarkers of Stress Resilience: Role of ELK1 and GPR56
NCT05488418
Assistance Publique Hopitaux De MarseilleN/A
CompletedSleep Signal Analysis for Current Major Depressive Episode (SAMDE)
NCT05708222
Medibio Limited
CompletedTrial of Transcranial Photobiomodulation for Depression With PET and EEG Outcomes
NCT06934135
NeuroThera DEN/A
UnknownThe Efficacy of Acupressure Therapy on Patient With Depression
NCT05423405
University Psychiatric Clinics BaselN/A
UnknownSmartphone App Based CBT Versus Online Group CBT: Randomized, Non-inferiority Clinical Trial
NCT05450614
Hospital de Clinicas de Porto AlegreN/A
CompletedAn Energetic View on Creativity, Psychopathology and Intelligence: The Brain2Business Study
NCT05544877
Psychiatrische Dienste ThurgauN/A
CompletedA Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Mo
NCT05455684
Janssen Research & Development, LLCPhase 3
UnknownMicrobiotherapy in Characterized Depressive Disorder
NCT05280015
Centre Hospitalier Universitaire de BesanconPhase 2
RecruitingAerobic Versus Leisure Group for Adolescents With Depression
NCT05076214
Lund University HospitalN/A
TerminatedA Randomized Control Trial Treating Depression With Yoga and Coherent Breathing Versus Walking in Veterans
NCT03489122
VA Office of Research and DevelopmentN/A
UnknownProspective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA
NCT05306184
Radboud University Medical Center
WithdrawnRapid Acting TMS for Suicide Ideation in Depression
NCT05100004
Stanford UniversityN/A
UnknownThe Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Diso
NCT04984512
Sunshine Lake Pharma Co., Ltd.Phase 2 / Phase 3
TerminatedA Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a S
NCT05109195
Janssen Research & Development, LLC
CompletedSynaptic Imaging and Network Activity in Treatment Resistant Depression
NCT05870501
King's College LondonN/A
UnknownTreatment of Major Depression by rTMS on Dorsolateral Prefrontal Cortex: Study of Underlying Mechanisms
NCT05121129
Centre Hospitalier Universitaire de BesanconN/A
TerminatedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder
NCT04951609
Janssen Research & Development, LLCPhase 1
WithdrawnAssessment of the Impact of Clinical Pharmacogenomics on Real and Potential Medication Use in Veterans
NCT04893395
Auburn UniversityN/A
CompletedProbiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?
NCT04772664
Medical University of GrazN/A
UnknownSevoflurane for Treatment-Resistant Depression
NCT05008939
Shanghai First Maternity and Infant HospitalN/A
CompletedA Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Dep
NCT04937829
Boehringer IngelheimPhase 1
Active Not RecruitingTreatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
NCT04870255
Stanford UniversityN/A
CompletedNeuro MRI Biomarkers for Treatment Navigation in Depression
NCT05701267
Eindhoven University of Technology
RecruitingPrecision Medicine in the Depression Treatment
NCT05616559
Rigshospitalet, Denmark
UnknownDexmedetomidine Adjuvant Treatment for Depressed Patients Undergoing ECT
NCT04661475
Sultan Qaboos UniversityPhase 4
CompletedA Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Contin
NCT04829318
Janssen-Cilag Ltd.Phase 4
UnknownDeep Brain Stimulation for Treatment Resistant Depression
NCT05716555
Second Affiliated Hospital, School of Medicine, Zhejiang UniversityN/A
CompletedAerobic Group Exercise for Adolescents With Depression
NCT04695145
Lund University HospitalN/A
CompletedEvaluate the Quality of Life and Treatment of Anxiety Symptoms of Buspirone in Patients With Depression Disord
NCT04770454
Boryung Pharmaceutical Co., Ltd
CompletedMusic as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression
NCT04701866
Douglas Mental Health University InstituteN/A
UnknownAlpha-Stim AID and Major Depressive Disorder
NCT04963907
Electromedical Products International, Inc.N/A
CompletedWeb-based Self-help Intervention for Adolescents With Acute or Remitted Major Depressive Disorder
NCT04994470
Ludwig-Maximilians - University of MunichN/A
CompletedA Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of
NCT04669665
Seelos Therapeutics, Inc.Phase 2
RecruitingBiomarkers of Depression and Treatment Response
NCT04581902
University of California, San FranciscoN/A
CompletedIn-person vs. Remote Wellness Support
NCT04526067
The University of Texas Health Science Center at San AntonioN/A
TerminatedAccelerated Bilateral rTMS on Geriatric Depression
NCT04486222
National Taiwan University HospitalN/A
CompletedA Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
NCT04521478
Boehringer IngelheimPhase 2
CompletedCognitive Fitness for Depression in Older Adults
NCT04790630
UConn HealthN/A
CompletedA Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major D
NCT04476030
BiogenPhase 3
UnknownA Study to Evaluate the Benefit of Opti-Me Application to Different Treatments of MDD
NCT04148612
ElMindA LtdN/A
CompletedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major D
NCT04533529
Janssen Research & Development, LLCPhase 3
TerminatedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major D
NCT04532749
Janssen Research & Development, LLCPhase 3
CompletedA Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly
NCT04513912
Janssen Research & Development, LLCPhase 3
WithdrawnNESBID: Neuro-Stimulation of the Brain in Depression
NCT04159012
University of AlbertaN/A
CompletedA Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With
NCT04338321
Janssen-Cilag International NVPhase 3
CompletedSimvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major De
NCT04301271
Charite University, Berlin, GermanyPhase 2
CompletedUsing Repetitive Transcranial Magnetic Stimulation to Study the Role of Frontostriatal Circuit in Major Depres
NCT05212636
National Cheng-Kung University HospitalN/A
CompletedA Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Par
NCT04451187
Janssen Research & Development, LLCPhase 1
UnknownPersonalized Sertraline Dosing in Patients With Depression
NCT05210153
University of Belgrade
UnknownPersonalized Escitalopram Dosing in Patients With Depression
NCT05210140
University of Belgrade
CompletedA Study to Describe Routine Treatment Pathways in Participants With Major Depression and Active Suicidal Ideat
NCT04463108
Janssen-Cilag S.p.A.
TerminatedA Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression
NCT04423757
Boehringer IngelheimPhase 2
CompletedA Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Diso
NCT04442490
BiogenPhase 3
CompletedICBT for Depression - A Factorial Investigation of Kinds of Therapist Support and Self-/Expert-selected Conten
NCT04260750
Linkoeping UniversityN/A
CompletedAntidepressant Decision Aid for Major Depressive Disorder Patients
NCT04761757
University of MalayaN/A
UnknownEfficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent
NCT04171193
University of Sao PauloPhase 2
UnknownEffects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder Patients
NCT04179006
National Cheng-Kung University HospitalN/A
RecruitingOptimal Electrical Stimulus During Electroconvulsive Therapy
NCT04057378
Region Örebro CountyPhase 4
TerminatedMajor Depressive Disorder: Early Prediction of Non-response to Antidepressant Therapy Via a Mobile Digital Sca
NCT03872492
Ad scientiamN/A
CompletedA Study of Psilocybin for Major Depressive Disorder (MDD)
NCT03866174
Usona InstitutePhase 2
UnknownAntidepressant Trial With P2X7 Antagonist JNJ-54175446
NCT04116606
CCTU-CorePhase 2
TerminatedEffectiveness of IPT-G in Major Depression
NCT04015206
Hospital de Clinicas de Porto AlegreN/A
WithdrawnStudy of Rapastinel as Monotherapy in Major Depressive Disorder (MDD)
NCT03855865
Naurex, Inc, an affiliate of Allergan plcPhase 3
UnknownKetamine for Mood Disorders With Suicidal Ideation
NCT04099771
The Miriam HospitalEARLY_Phase 1
CompletedPatient Outcomes Reporting for Timely Assessments of Life With Depression: PORTAL-Depression
NCT03832283
University of ChicagoN/A
UnknownThe Effect of Probiotic Supplementation on the Mental Status, Inflammation, and Intestinal Barrier in Major De
NCT03877393
Medical University of LublinN/A
CompletedNitrous Oxide for Major Depressive Disorder
NCT03932825
Lingjiang LiPhase 2
CompletedA Study in People With Depression to Test the Effects of BI 1358894 on Parts of the Brain That Are Involved in
NCT03854578
Boehringer IngelheimPhase 1
CompletedClinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept
NCT03715127
University of ZurichPhase 2
CompletedTriple Chronotherapy in Adolescents
NCT03679962
Billings ClinicN/A
UnknownVortioxetine for Treatment of Depressive Mood and Alcohol Use
NCT04498897
Hanyang University Seoul HospitalPhase 2
CompletedCoil Positioning in Navigated Transcranial Magnetic Stimulation Feasibility in Depression Patients Trial
NCT03795051
MagstimN/A
CompletedPsilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms
NCT03429075
Imperial College LondonPhase 2
CompletedAlpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine
NCT03367533
Yale UniversityPhase 1
WithdrawnRescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and
NCT03758495
VA Office of Research and Development
TerminatedStudy of Rapastinel as Monotherapy in Patients With Major Depressive Disorder (MDD)
NCT03675776
Naurex, Inc, an affiliate of Allergan plcPhase 3
SuspendedKetamine Versus Electroconvulsive Therapy in Depression
NCT03674671
University of OttawaPhase 3
UnknownKetamine for Treatment Resistant MDD
NCT04021433
Hadassah Medical OrganizationN/A
CompletedOlfactory Training and Emotional State
NCT03605524
University Hospital, ToursN/A
TerminatedStudy of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
NCT03668600
Naurex, Inc, an affiliate of Allergan plcPhase 3
TerminatedStudy of Monotherapy Rapastinel in the Prevention of Relapse in Patients With Major Depressive Disorder (MDD)
NCT03614156
Naurex, Inc, an affiliate of Allergan plcPhase 3
UnknownResting-state Functional Connectivity Throughout a Course of iTBS in Major Depression
NCT03944213
University Hospital, Bonn
CompletedA Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression
NCT03559192
Janssen Research & Development, LLCPhase 2
TerminatedStudy of Rapastinel as Monotherapy in Patients With MDD
NCT03560518
Naurex, Inc, an affiliate of Allergan plcPhase 3
CompletedZelquistinel in the Treatment of Major Depressive Disorder
NCT03586427
Syndeio Biosciences, IncPhase 2
CompletedPharmacogenetics Informed Tricyclic Antidepressant Dosing (PITA)
NCT03548675
Radboud University Medical CenterPhase 4
CompletedSafety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017
NCT03051256
Relmada Therapeutics, Inc.Phase 2
CompletedDoes Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?
NCT03436823
Rennes University HospitalN/A
CompletedSleep, Wake and Light Therapy for Depression
NCT03405493
King's College LondonN/A
CompletedA Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depre
NCT03374475
Janssen Research & Development, LLCPhase 1
CompletedAttention Bias Modification Treatment for Young Adults With Major Depressive Disorder
NCT03971903
Hunan Normal UniversityN/A
TerminatedA Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder
NCT03352453
Naurex, Inc, an affiliate of Allergan plcPhase 2
CompletedA Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release a
NCT03321526
Janssen Research & Development, LLCPhase 2
CompletedAdaptive Design Study of NEST sTMS in Subjects With Major Depressive Disorder
NCT03288714
Wave NeuroscienceN/A
CompletedNeurobehavioral Mechanisms of Emotion Regulation in Depression Across the Adult Lifespan
NCT03207503
Duke University
CompletedStepped Care AiTBS 2 Depression Study (Ghent)
NCT03288675
University Hospital, GhentN/A
CompletedStudy to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensi
NCT03185819
Janssen Research & Development, LLCPhase 2
CompletedMolecular Imaging of Brain Inflammation in Depressive Disorders
NCT02983318
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
CompletedA Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult
NCT03227224
Janssen Research & Development, LLCPhase 2
TerminatedNeuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients
NCT02737540
Centre Hospitalier Universitaire de Nīmes
CompletedExploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI Study
NCT03040388
University of Copenhagen
TerminatedFeasibility of a Technology-Based Treatment Support System
NCT03121937
Northwestern UniversityN/A
Completed54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehen
NCT03097133
Janssen Research & Development, LLCPhase 3
Completed54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehen
NCT03039192
Janssen Research & Development, LLCPhase 3
CompletedA Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-911 in Healthy Subjects
NCT03155503
Suven Life Sciences LimitedPhase 1
CompletedPromote Access to Stop Suicide: Comparison of Follow up Services for Youth at Risk for Suicide
NCT03016572
The Cleveland ClinicN/A
CompletedContinuation With Vortioxetine in Child and Adolescent Patients With Major Depressive Disorder (MDD) From 7 to
NCT03108625
H. Lundbeck A/SPhase 3
CompletedStepped Care for Depression in Heart Failure
NCT02997865
Washington University School of MedicineN/A
UnknownProbing Prefrontal Cortex Hemodynamic Alterations for Major Depression Disorder
NCT03595020
Xijing Hospital
CompletedLong-term Safety Study of Rapastinel as Adjunctive Therapy in Patients With Major Depressive Disorder
NCT03002077
Naurex, Inc, an affiliate of Allergan plcPhase 3
TerminatedNMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
NCT02994433
Washington University School of MedicinePhase 1
CompletedCognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant Depress
NCT03027362
Yale UniversityN/A
CompletedInhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies
NCT03283670
Washington University School of MedicinePhase 2
CompletedA Study of Rapastinel as Adjunctive Therapy in the Prevention of Relapse in Patients With Major Depressive Dis
NCT02951988
Naurex, Inc, an affiliate of Allergan plcPhase 3
CompletedGaze Contingent Feedback in Major Depressive Disorder (MDD)
NCT02945735
Tel Aviv UniversityN/A
CompletedA Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)
NCT02943577
Naurex, Inc, an affiliate of Allergan plcPhase 3
CompletedCan the Memory Support Intervention Improve Depression Outcome Following Cognitive Therapy?
NCT02938559
University of California, BerkeleyN/A
CompletedA Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)
NCT02943564
Naurex, Inc, an affiliate of Allergan plcPhase 3
CompletedStudy to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Te
NCT03014544
Janssen Research & Development, LLC
CompletedA Study to Investigate the Safety, Tolerability, and Pharmacodynamics of JNJ-54175446 in Participants With Maj
NCT02902601
Janssen Research & Development, LLCPhase 1
CompletedA Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)
NCT02932943
Naurex, Inc, an affiliate of Allergan plcPhase 3
CompletedA 7-year Assessment on Subject Understanding of ZYBAN/ WELLBUTRIN Associated Risks
NCT03001440
GlaxoSmithKline
CompletedA Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road
NCT02919579
Janssen Research & Development, LLCPhase 1
CompletedThe Effects of tDCS on Depressive Symptoms,Neurocognitive Function and HRV in Unipolar Depression and Bipolar
NCT03287037
Tri-Service General HospitalN/A
CompletedStudy of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day
NCT02919501
H. Lundbeck A/SPhase 2
TerminatedLong-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants Wit
NCT02871297
H. Lundbeck A/SPhase 3
CompletedStimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder
NCT04081519
University Hospital, BonnN/A
CompletedIntegrated Smoking Cessation Treatment for Smokers With Serious Mental Illness
NCT02845440
Massachusetts General HospitalN/A
CompletedA Study to Evaluate Pharmacokinetics, Safety and Tolerability of Extended-release Bupropion Hydrochloride Tabl
NCT02698553
GlaxoSmithKlinePhase 1
CompletedActive Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years W
NCT02709655
H. Lundbeck A/SPhase 3
CompletedEffects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder
NCT04013464
Peking University Sixth HospitalN/A
CompletedChronobiology, Sleep Related Risk Factors and Light Therapy in Perinatal Depression: the Life-ON Project
NCT02664467
Ospedale Regionale di LuganoN/A
CompletedActive Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With
NCT02709746
H. Lundbeck A/SPhase 3
CompletedBrain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.
NCT02741622
St. Olavs HospitalN/A
CompletedNMDA Modulation in Major Depressive Disorder in Late- Life
NCT03414931
Chang Gung Memorial HospitalPhase 2
CompletedDepression and Immune Function in Multiple Sclerosis (MS)
NCT02740296
Charite University, Berlin, Germany
SuspendedPredictors of Treatment Response in Late-onset Major Depressive Disorder
NCT02546024
King's College London
CompletedLow Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
NCT02452892
Tal Medical, Inc.N/A
CompletedClinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD
NCT03721588
Bozyaka Training and Research Hospital
CompletedAn Efficacy and Safety Study of Sirukumab in Participants With Major Depressive Disorder
NCT02473289
Janssen Research & Development, LLCPhase 2
CompletedPharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disord
NCT02466477
Assurex Health Inc.Phase 4
CompletedPeripheral Immunomarker Validation in Treatment-resistant Depression
NCT02752178
University of Cambridge
CompletedNeuroQore rTMS (Monophasic vs. Biphasic) for Major Depressive Disorder: A Randomized Controlled Pilot Trial
NCT02667041
University of OttawaN/A
CompletedAdolescent Mental Health: Canadian Psychiatric Risk and Outcome Study
NCT02739932
University of Calgary
UnknownThe Effect of Traumatic Childbirth on the Incidence of PTSD and Other Major Postpartum Psychopathology
NCT02370576
Rambam Health Care Campus
CompletedE-Compared-CH: Comparative Effectiveness Research on Internet-based Depression Treatment - Swiss Trial
NCT02410616
University of BernN/A
CompletedA Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise
NCT02407704
Kirk Erickson, PhDPhase 4
CompletedStudy to Evaluate the Efficacy, Safety and Tolerability of Bupropion Hydrochloride Extended-release Tablet, an
NCT02191397
GlaxoSmithKlinePhase 3
CompletedKetamine as an Alternative Treatment to ECT in Major Depressive Disorder
NCT02659085
Pouya Movahed RadPhase 2 / Phase 3
CompletedCombining Data Sources to Identify Effect Moderation for Personalized Mental Health
NCT05267873
Johns Hopkins Bloomberg School of Public Health
CompletedStudy to Evaluate Potential Predictors of Relapse in Participants With Major Depressive Disorder (MDD)
NCT02489305
Janssen Research & Development, LLC
CompletedA Multicenter, Relapse Prevention Study With Levomilnacipran Extended Release (ER) in Participants With Major
NCT02288325
Forest LaboratoriesPhase 4
CompletedConfirmation Bias Towards Treatments of Depressive Disorders in Social Tagging
NCT03899168
Leibniz-Institut für WissensmedienN/A
CompletedPharmacogenetic Implementation Trial in Veterans With Treatment Refractory Depression
NCT04469322
San Diego Veterans Healthcare SystemN/A
UnknownKetamine Infusions for Major Depression Disorder
NCT02219867
Sheba Medical CenterN/A
CompletedDialogue to Empower Traditional and Faith Healers to Deliver mhGAP-IG Adapted Psychosocial Interventions in Ke
NCT03165513
Africa Institute of Mental and Brain Health (AFRIMEB)N/A
CompletedTrial to Evaluate Efficacy of Pharmacogenetic Information Obtained With NEUROPHARMAGEN in Treatment of MDD Pat
NCT02529462
AB Biotics, SAPhase 3
CompletedStudy of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatmen
NCT02196506
Otsuka Pharmaceutical Development & Commercialization, Inc.Phase 3
CompletedOnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Females
NCT02116361
AllerganPhase 2
CompletedA Study to Evaluate the Impact of Escitalopram on Quality of Life and Social Functionality in Patients With Ma
NCT01870843
Xian-Janssen Pharmaceutical Ltd.Phase 4
CompletedA Study to Investigate the Effect of JNJ-42847922 on Polysomnography Measures in Patients With Major Depressiv
NCT02067299
Janssen Research & Development, LLCPhase 1
CompletedA Randomized Controlled Trial of PCIT-ED for Preschool Depression
NCT02076425
Washington University School of MedicineN/A
CompletedThe Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of
NCT04272476
Chengdu University of Traditional Chinese MedicinePhase 2
CompletedPRJ2215: Assessment of Buproprion Misuse/Abuse 2004-2011
NCT02039960
GlaxoSmithKline
UnknownObjective Diagnostic Markers and Personalized Intervention in MDD Patients
NCT02023567
Peking UniversityN/A
CompletedA Clinical Trial for the Treatment of Depression With Repetitive Transcranial Magnetic Stimulation (rTMS)
NCT01909232
Cervel Neurotech, Inc.N/A
CompletedA Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive
NCT01727726
Otsuka Pharmaceutical Development & Commercialization, Inc.Phase 3
CompletedMommy-Baby Treatment for Perinatal Depression
NCT01744041
Washington University School of MedicineN/A
CompletedCortical Excitability and Inhibition in MDD
NCT01718730
Mayo Clinic
CompletedWhole Body Hyperthermia and Major Depression (MDD)
NCT01625546
University of ArizonaN/A
CompletedEfficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder
NCT01564862
TakedaPhase 2
WithdrawnBrain Imaging, Genetics and Treatment for Major Depression
NCT01568684
National Institute of Mental Health (NIMH)Phase 1
CompletedCharacterization of the Prosocial and Prosexual Effects of GHB
NCT02342366
University of ZurichN/A
CompletedSafety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the
NCT01360866
Otsuka Pharmaceutical Development & Commercialization, Inc.Phase 3
CompletedA Study to Evaluate the Effect of Clarithromycin on LY2216684
NCT01460407
Eli Lilly and CompanyPhase 1
CompletedA Study to Evaluate the Effect of Genotype on LY2216684
NCT01460381
Eli Lilly and CompanyPhase 1
CompletedBuprenorphine for Treatment Resistant Depression
NCT01407575
University of PittsburghPhase 3
CompletedEnhanced Collaborative Depression Treatment in Primary Care: The RESPECT-D-E Trial
NCT01583400
Dartmouth-Hitchcock Medical CenterN/A
CompletedA Study to Evaluate the Effect of Activated Charcoal on the Absorption of LY2216684 in Healthy Subjects
NCT01389752
Eli Lilly and CompanyPhase 1
CompletedStudy of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With
NCT01360645
Otsuka Pharmaceutical Development & Commercialization, Inc.Phase 3
CompletedA Study to Evaluate the Effect of Food on LY2216684
NCT01389765
Eli Lilly and CompanyPhase 1
CompletedStudy of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adu
NCT01360632
Otsuka Pharmaceutical Development & Commercialization, Inc.Phase 3
CompletedA Study of LY2216684 in Healthy Females
NCT01373931
Eli Lilly and CompanyPhase 1
CompletedEuropean Deep Brain Stimulation (DBS) Depression Study
NCT01331330
Abbott Medical DevicesN/A
CompletedRetrospective Database Study of Real World Abilify Outcomes in Major Depressive Disorder (MDD)
NCT01284218
Otsuka Pharmaceutical Development & Commercialization, Inc.
CompletedEfficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder
NCT01255787
TakedaPhase 2 / Phase 3
CompletedInterventional Study of Wellbutrin XL in Major Depressive Disorder With Atypical Features
NCT01477931
Chi-Un PaePhase 4
CompletedA Study of LY2216684 in Participants With Impaired Hepatic Function
NCT01241435
Eli Lilly and CompanyPhase 1
CompletedA Safety Study in Participants With Major Depressive Disorder
NCT01155661
Eli Lilly and CompanyPhase 3
CompletedSafety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Study
NCT01152996
TakedaPhase 3
CompletedSafety and Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
NCT01179516
TakedaPhase 3
CompletedEfficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
NCT01163266
TakedaPhase 3
CompletedA Fixed Dose Study of 323U66 SR in the Treatment of Major Depressive Disorder (MDD)
NCT01138007
GlaxoSmithKlinePhase 3
CompletedSafety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
NCT01153009
TakedaPhase 3
CompletedEfficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
NCT01033084
University of Sao PauloPhase 2 / Phase 3
CompletedClinical Study to Test a New Drug to Treat Major Depression
NCT00976560
GlaxoSmithKlinePhase 2
CompletedAn Efficacy and Safety Study of Escitalopram Long-Term Treatment in Major Depressive Disorder With Associated
NCT01814098
Xian-Janssen Pharmaceutical Ltd.Phase 4
CompletedInsulin Resistance in Patients With Major Depression
NCT01106313
Stanford University
CompletedGABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression
NCT00931619
National Institute of Neurological Disorders and Stroke (NINDS)
CompletedThe Effect of Patient Cost-Sharing on Antidepressant and Adjunctive Therapy Use
NCT01141400
Otsuka Pharmaceutical Development & Commercialization, Inc.
CompletedIdentifying Very Early Response to Seroquel Extended Release (XR) Augmentation for Major Depressive Disorder
NCT00892463
Sunnybrook Health Sciences CentrePhase 4
CompletedOutcomes in MEasurement-Based Treatment
NCT01141387
Otsuka Pharmaceutical Development & Commercialization, Inc.
CompletedMindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent Depression
NCT00928980
Radboud University Medical CenterN/A
TerminatedA Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and S
NCT00880399
GlaxoSmithKlinePhase 2
CompletedA Study of Adjunctive Treatment to Antidepressant Therapy for Adults With Major Depressive Disorder
NCT00840034
Eli Lilly and CompanyPhase 2
CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release In Outpatients With Major Depressive Disorder
NCT00824291
Wyeth is now a wholly owned subsidiary of PfizerPhase 3
CompletedDuloxetine in Patients With Diabetic in Peripheral Neuropathic Pain With or Without Co-morbid Major Depressive
NCT00844194
Boehringer IngelheimPhase 4
CompletedA Study in Adult Patients With Major Depressive Disorder
NCT00795821
Eli Lilly and CompanyPhase 2 / Phase 3
CompletedA Study of the Effects of a New Antidepressant Treatment (GSK561679) in Females With Major Depressive Disorder
NCT00733980
GlaxoSmithKlinePhase 2
Enrolling By InvitationPsychiatric Genotype/Phenotype Project Repository
NCT00762866
Vanderbilt University
CompletedSwitching to Duloxetine in Patients With Depression
NCT00696774
Eli Lilly and CompanyPhase 4
CompletedPioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrome
NCT00671515
Joseph Calabrese, MDPhase 2
CompletedA Study of Transcranial Direct Current Stimulation (tDCS) to Treat Depression
NCT00763230
The University of New South WalesPhase 2 / Phase 3
CompletedAdvanced MRI in Major Depression
NCT00613912
University of Aarhus
TerminatedPrevention of Depression in HIV/HCV Co-infected Substance Abuse Patients
NCT00655226
Icahn School of Medicine at Mount SinaiN/A
TerminatedDeep Brain Stimulation for Major Depressive Disorder
NCT00617162
Abbott Medical DevicesN/A
CompletedDecentering and Relapse/Recurrence in MBCT for Depression in Adults
NCT05111665
University of British ColumbiaN/A
CompletedAn Eight-week Study of Saredutant and Paroxetine as Combination Treatment for Major Depressive Disorder
NCT00629551
SanofiPhase 3
CompletedRandomised Controlled Trial of Electroconvulsive Therapy (ECT) in Relapse Prevention of Depression
NCT00627887
Örebro County CouncilPhase 4
CompletedA Safety, Efficacy and Tolerability Study of SEP-225289
NCT00584974
Sumitomo Pharma America, Inc.Phase 2
CompletedSA4503 8-Week Study in Major Depressive Disorder (MDD)
NCT00551109
M's Science CorporationPhase 2
CompletedPatient Tolerability Study of GSK163090
NCT00559299
GlaxoSmithKlinePhase 1
CompletedImpact of Atypical Antipsychotic Therapy on Health Outcomes and Costs Among Patients With Major Depressive Dis
NCT01145313
Otsuka Pharmaceutical Development & Commercialization, Inc.
TerminatedA Study of GW856553X For the Treatment of Depression
NCT00569062
GlaxoSmithKlinePhase 2
CompletedParoxetine-referenced Study Evaluating Three Doses of DVS SR in Outpatients With MDD
NCT00445679
Wyeth is now a wholly owned subsidiary of PfizerPhase 3
CompletedAuricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive
NCT02340351
Universitätsklinikum Hamburg-EppendorfN/A
CompletedSt. John's Wort And Kava In The Treatment Of Major Depressive Disorder With Comorbid Anxiety
NCT00451516
The University of QueenslandPhase 2
CompletedStudy to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe Depression
NCT02229825
Boehringer IngelheimPhase 4
CompletedStudy Evalutating the Pharmacokinetics (PK) and Safety of a Single Dose of Desvenlafaxine Sustained Release (D
NCT00440427
Wyeth is now a wholly owned subsidiary of PfizerPhase 1
CompletedStudy Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway
NCT00456898
Wyeth is now a wholly owned subsidiary of PfizerPhase 1
CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women
NCT00406640
Wyeth is now a wholly owned subsidiary of PfizerPhase 3
CompletedA Local Register Study For Major Depression Of Paroxetine Controlled Release
NCT00368303
GlaxoSmithKlinePhase 3
CompletedStudy for Evaluating Different Methods of Measuring Depression Treatment Response
NCT00406952
PfizerN/A
WithdrawnThe Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorder
NCT00451490
National Taiwan University HospitalN/A
CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausa
NCT00369343
Wyeth is now a wholly owned subsidiary of PfizerPhase 3
CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Diso
NCT00384033
PfizerPhase 3
CompletedStudy Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjec
NCT00366652
Wyeth is now a wholly owned subsidiary of PfizerPhase 3
CompletedStudy on the Influence of Electroconvulsive Therapy (ECT) on Homocysteine Levels
NCT00370058
University of Erlangen-Nürnberg Medical SchoolPhase 4
CompletedOpen-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Tal
NCT00401726
Wyeth is now a wholly owned subsidiary of PfizerPhase 4
CompletedOpen-label Ziprasidone Study for Psychosis Treatment in Adolescents
NCT00421954
New York State Psychiatric InstitutePhase 3
CompletedAndroGel in Men With Major Depression and Incomplete Response to Antidepressant Treatment
NCT00304746
Mclean HospitalPhase 4

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