NCT02741622

Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: St. Olavs Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression. The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Conditions

• Depressive Disorder
• Depressive Disorder, Major

Interventions

Type	Name	Description
BEHAVIORAL	High aerobic intensity training (HIT)	One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)
BEHAVIORAL	Long slow distance training (LSD)	One training session, long slow distance training (LSD) at 70 % of the HRmax

Timeline

• Start date: 2016-03-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2016-04-18
• Last updated: 2018-12-04

Locations

1 site across 1 country: Norway