NCT00928980

Mindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent Depression

The Clinical and Cost-effectiveness of Mindfulness Based Cognitive Therapy, Maintenance Antidepressant Medication and Its Combination in the Prevention of Relapse in Patients With Recurrent Depression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 317 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the (cost)effectiveness of mindfulness based cognitive therapy (MBCT) compared to that of antidepressant medication, and its combination with regard to the prevention of relapse or recurrence in patients with recurrent depression.

Detailed description

In the Netherlands, treatment as usual for patients with (recurrent) Major Depressive Disorder consists of maintenance antidepressant medication. Mindfulness-based cognitive therapy (MBCT) is a recently developed psychological intervention that appears to be promising in terms of preventing relapse or recurrence in patients with recurrent depression. It consists of 8 weekly group sessions in which meditation exercises are combined with cognitive therapeutic elements such as identifying negative thoughts and monitoring and scheduling activities. In this study, the (cost)effectiveness of a) MBCT on its own, b) antidepressant medication on its own and c) the combination of MBCT and antidepressant medication will be investigated in 350 patients with recurrent depression who are currently in remission.

Conditions

• Depressive Disorder, Major

Interventions

Type	Name	Description
BEHAVIORAL	Mindfulness Based Cognitive Therapy	Mindfulness Based Cognitive Therapy is an 8-week during group intervention encompassing meditation practice and cognitive therapy techniques.
DRUG	Optimal Medical Care	Therapeutic dose of antidepressant medication

Timeline

• Start date: 2009-05-01
• Primary completion: 2013-06-01
• Completion: 2013-06-01
• First posted: 2009-06-26
• Last updated: 2020-11-13

Locations

13 sites across 1 country: Netherlands