NCT00613912

Advanced MRI in Major Depression

Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 49 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Depression is the most common psychiatric disorder. * 3-5% of a given population has major depression. * Less than 50% of the depressed in Denmark are diagnosed with major depression. * 25-50% of the depressed have a relative with major depression-underlying brain pathology? The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Detailed description

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed. MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Conditions

• Depressive Disorder, Major

Interventions

Type	Name	Description
OTHER	Magnetic Resonance Imaging	* Morphological sequences * Arterial Spin Labelling (Perfusion) * Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter

Timeline

• Start date: 2008-03-01
• Primary completion: 2009-12-01
• Completion: 2011-06-01
• First posted: 2008-02-13
• Last updated: 2011-11-21

Locations

1 site across 1 country: Denmark