NCT05267873

Combining Data Sources to Identify Effect Moderation for Personalized Mental Health

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9,586 (actual)
• Sponsor: Johns Hopkins Bloomberg School of Public Health · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: —

Summary

This work will extend and apply methods for modeling heterogeneous treatment effects when multiple studies are available, with a particular focus on the complexities in mental health research. The methods will be illustrated in examples estimating the effects of medical treatments for major depressive disorder (duloxetine and vortioxetine) using 4 randomized controlled trials (available in the Vivli trials resource) and non-experimental data from the Duke University Health System electronic health record and the Johns Hopkins Health System electronic health record systems.

Conditions

• Depressive Disorder, Major

Interventions

Type	Name	Description
DRUG	Duloxetine, Vortioxetine	Medications for major depressive disorder

Timeline

• Start date: 2015-01-01
• Primary completion: 2021-12-31
• Completion: 2024-12-01
• First posted: 2022-03-04
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study