NCT06165445

Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder

Optimized Multichannel tDCS Protocol vs Conventional and Sham tDCS for Clinical Use in Patients With Major Depressive Disorder

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: The National Brain Mapping Laboratory (NBML) · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

In this project, the efficacy of different tDCS protocols in major depression will be investigated. The tDCS protocols have already been investigated in humans, and results showed that stimulation intensity has a different effect on tDCS long-term aftereffects based on the human motor cortex model. The project has three major goals: first, we want to see if the differential outcome of tDCS dosage, as present in healthy populations, can be translated to patients with major depression. Second, we want to compare the efficacy of a multi-channel novel protocol with conventional tDCS modules. Lastly, we are interested in the safety and tolerability of optimized multi-channel. The project output will be an optimized tDCS protocol for major depression treatment.

Conditions

• Depressive Disorder
• Cognitive Impairment
• Psychiatric Disorder

Interventions

Type	Name	Description
DEVICE	transcranial direct current stimulation (tDCS)	In tDCS, direct electrical currents at the intensity of interest (2 mA for example) are generated by an electrical stimulator and are noninvasively delivered to the scalp through a pair of saline-soaked sponge electrodes (7×5 cm) or via more than two but smaller round electrodes over the target regions.
DEVICE	multichannel transcranial direct current stimulation (tDCS)	In multichannel tDCS, direct electrical currents at the intensity of interest (2 mA for example) are generated by an electrical stimulator and are noninvasively delivered to the scalp through more than two and smaller round electrodes over the target regions.

Timeline

• Start date: 2021-06-01
• Primary completion: 2022-12-01
• Completion: 2023-03-01
• First posted: 2023-12-11
• Last updated: 2026-03-18

Locations

1 site across 1 country: Iran