NCT07399756

Mitochondrial Function After Ketamine

Assessment of Mitochondrial Parameters in Blood Before and After S-Ketamine Treatment

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Sheba Medical Center · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to learn about the role of mitochondria in response to S-ketamine. in individuals with Treatment-Resistant Depression. the Research Questions are 1. Does S-ketamine treatment modulate mitochondrial function in peripheral blood cells, as reflected by mitochondrial content and circulating mitochondrial biomarkers such as GDF15? 2. Can changes in mitochondrial function serve as biomarkers for predicting or monitoring clinical response to S-ketamine treatment? Samples will be collected at baseline, 3 hours after the first treatment, and 6 weeks post-exposure, and compared between responders and non-responders

Conditions

• Major Depressive Disorder

Interventions

Type	Name	Description
DRUG	S (+) Ketamine	the patients are treated with S-Ketamine in order to treat there Treatment-Resistant Depression via inhalation

Timeline

• Start date: 2026-02-01
• Primary completion: 2026-09-01
• Completion: 2028-01-01
• First posted: 2026-02-10
• Last updated: 2026-02-10

Locations

1 site across 1 country: Israel