Acute Pain

465 registered clinical trials studyying Acute Pain — 52 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	VR-PAT and fNIRS to Identify CNS Biomarkers of Pain NCT06303687	Nationwide Children's Hospital	N/A
Not Yet Recruiting	REctus Sheath Trial NCT07068243	Duke University	Phase 2
Not Yet Recruiting	The Role of NaV1.8 in Human Pain Models NCT07511400	Medical University of Vienna	EARLY_Phase 1
Not Yet Recruiting	A Study of LY4515100 in Participants With Pain Following Third Molar Removal NCT07511816	Eli Lilly and Company	Phase 2
Not Yet Recruiting	Effects of Breastfeeding, Virtual Reality, and Stress Ball on Pain, Anxiety, Cortisol Levels, and Comfort Duri NCT07510477	Aydin Adnan Menderes University	N/A
Not Yet Recruiting	Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children. NCT06968546	Fondation Lenval	Phase 2
Recruiting	Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surger NCT06779604	Umraniye Education and Research Hospital	—
Not Yet Recruiting	A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain NCT07225634	AFT Pharmaceuticals, Ltd.	Phase 3
Not Yet Recruiting	Comparing the Postoperative Analgesic Efficacy of Anterior Iliac Block and Ilioinguinal-iliohypogastric Block NCT07290881	Harran University	N/A
Not Yet Recruiting	M-TAPA Block for Analgesia After Open-Heart Surgery NCT07232979	Bursa City Hospital	N/A
Not Yet Recruiting	Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy NCT07321639	Istanbul Medipol University Hospital	N/A
Recruiting	Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery NCT07348419	Samsun University	N/A
Recruiting	Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention NCT07335159	Florida State University	N/A
Recruiting	Acute Effects of LLLT on Pain Threshold and Pain Tolerance NCT07422272	European University of Lefke	N/A
Recruiting	Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After NCT07348523	Samsun University	N/A
Recruiting	Characterization of Acute Pain NCT07336264	Children's National Research Institute	—
Not Yet Recruiting	Effectiveness of Retrolaminar Block in Lumbar Spine Fusion With Multimodal Analgesia NCT07291388	Pontificia Universidad Catolica de Chile	N/A
Not Yet Recruiting	IM İnjection-PAIN-Cold Spray and Stress Ball NCT07233694	Erzincan Binali Yildirim Universitesi	N/A
Enrolling By Invitation	Little NIRVANA for Pediatric Pain and Anxiety NCT06795126	Nationwide Children's Hospital	N/A
Recruiting	Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Pl NCT07472296	Uludag University	N/A
Recruiting	Clinical Utility of the Numerical Verbal Scale (NVS) and the Pain and Functional Activity Scale (PFAS) in the NCT07310953	Fundacin Biomedica Galicia Sur	N/A
Recruiting	Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography NCT07409753	Wake Forest University Health Sciences	Phase 2
Enrolling By Invitation	Healthy Children and Virtual Reality Mediation of Simulated Pain NCT06854991	Nationwide Children's Hospital	N/A
Completed	EOIB for Laparoscopic Sleeve Gastrectomy NCT07101835	Ondokuz Mayıs University	—
Not Yet Recruiting	the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery NCT06530563	Xiangya Hospital of Central South University	Phase 4
Completed	An Efficacy and Safety Study of LTG-001 Following Abdominoplasty NCT07102459	Latigo Biotherapeutics	Phase 2
Completed	The Implementation of a Post-operative Communication App to Improve Pain Control and Opioid Use NCT06124079	University of Minnesota	N/A
Active Not Recruiting	Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain NCT06344403	Beijing Tiantan Hospital	N/A
Not Yet Recruiting	Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB) NCT06967363	Peking University Third Hospital	—
Recruiting	ESKetamine Low-dose vs Ketamine Low-dose for Severe Acute Pain in Emergency Units, Comparison of PsychodyslEpt NCT06853041	Centre Hospitalier Universitaire de Nice	Phase 4
Recruiting	Performance and Safety of LightForce® Therapy Lasers on Lateral Ankle Sprain NCT06854016	DJO UK Ltd	N/A
Completed	Does Psychoeducation Improve the Pain Relief Derived From a Brief Intervention NCT06952049	Florida State University	N/A
Completed	A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected NCT06887959	Vertex Pharmaceuticals Incorporated	Phase 4
Completed	A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic NCT06887972	Vertex Pharmaceuticals Incorporated	Phase 4
Recruiting	Effect of Remote Local Peripheral Nerve Cooling on Pain of Arterial Puncture NCT06838572	The Second Affiliated Hospital of Chongqing Medical University	N/A
Completed	JKN2306 in Healthy Subjects: Single Ascending Dose and Food Effect Study NCT07412938	Joincare Pharmaceutical Group Industry Co., Ltd	Phase 1
Terminated	Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control NCT05402293	University of Alberta	—
Completed	Recto-Intercostal Fascial Plane (RIFP) Block in Laparoscopic Cholecystectomy Patients NCT06768593	Istanbul Medipol University Hospital	N/A
Not Yet Recruiting	Italian Data Registry of Patients Undergoing Peripheral Nerve Block Performed in the Emergency Departments NCT06707558	Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria	—
Completed	A Combination Mindfulness and Music Intervention for Acute Pain NCT06718218	Florida State University	N/A
Not Yet Recruiting	CPB for Arthroscopic Hip Surgery NCT06337968	The Second Hospital of Shandong University	N/A
Active Not Recruiting	Detection of Electrodermal Activity in Pain 1 NCT06678217	Copenhagen University Hospital, Hvidovre	N/A
Recruiting	Virtual Reality Intervention to Reduce Pain in Women Undergoing Elective Oocyte Cryopreservation NCT07484815	Hadassah Medical Organization	N/A
Recruiting	Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Oc NCT06184126	University of Maryland, Baltimore	N/A
Completed	A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy NCT06619847	Vertex Pharmaceuticals Incorporated	Phase 2
Completed	Intrathecal Morphine vs. Quadratus Lumborum Block for Pain in Laparoscopic Nephrectomy NCT06630858	Ondokuz Mayıs University	N/A
Completed	Examination of Psychological and Physiological Pathways Linking Gratitude and Pain NCT06317844	Black Hills State University	N/A
Completed	Does Choice Improve the Pain Relief Derived From a Brief Intervention NCT06582758	Florida State University	N/A
Completed	A Study of Cebranopadol for the Treatment of Acute Pain After Abdominoplasty NCT06545097	Tris Pharma, Inc.	Phase 3
Recruiting	Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery NCT06555107	Centre Hospitalier Universitaire, Amiens	N/A
Recruiting	Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute NCT06569953	The Second Affiliated Hospital of Chongqing Medical University	Phase 4
Recruiting	Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure NCT06471075	Florida State University	N/A
Completed	A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomy NCT06423703	Tris Pharma, Inc.	Phase 3
Not Yet Recruiting	Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Heada NCT06493838	Minia University	Phase 4
Recruiting	Understanding the Acute Pain Phenotype in Patients Undergoing Surgery NCT06466941	Brigham and Women's Hospital	—
Completed	CoPainHell: The Analgesic Effect of Alcohol and Music NCT06471985	Eske Kvanner Aasvang	N/A
Recruiting	Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain NCT06160778	University of Calgary	Phase 3
Completed	Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine NCT06235606	The University of Hong Kong	Phase 3
Recruiting	Effect of Virtual Reality Technology for Managment of Acute Pain in Outpatient Hysteroscopy NCT06424093	Egymedicalpedia	N/A
Enrolling By Invitation	Alternatives to Dental Opioid Prescribing After Tooth Extraction NCT06275191	Douglas Oyler	N/A
Completed	Emergency Department Digital Pain Self-Management Intervention to Improve Acute Low Back Pain Outcomes NCT06360341	University of Florida	N/A
Completed	The Impact of the Anaesthetic Technique Employed on the Quality of Recovery in Patients Undergoing Hysterectom NCT06461832	Samsun University	—
Completed	Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomize NCT07057934	Dr. Lutfi Kirdar Kartal Training and Research Hospital	N/A
Completed	Effect of Aromatherapy on Postoperative Pain: Randomized Clinical Trial NCT06294769	University of Sao Paulo	N/A
Recruiting	Twin Block, Pain Medications and Third Molar Extractions NCT04880707	Rutgers, The State University of New Jersey	Phase 2
Completed	Combination of Parasternal and Serratus Anterior Plane Block in Coronary Artery Bypass Graft Surgery NCT06326333	Ankara City Hospital Bilkent	N/A
Completed	Combined SAPB in MICS NCT06326320	Ankara City Hospital Bilkent	N/A
Completed	Music Therapy in Patients Undergoing Pancreatic Surgery (MUSIC PUPS) NCT06123013	University Hospitals Cleveland Medical Center	N/A
Unknown	Treatment of Topical Ketorolac Gel in Acute Gouty Flare NCT06273813	Novilla Pharmaceuticals	Phase 1
Unknown	Analgesic Self-medication for Acute Pain by Patients Awaiting a Consultation With a General Practitioner NCT05412407	Hospices Civils de Lyon	N/A
Completed	Analgesic Equivalence of NSAIDs and Tramadol in Acute Postoperative Pain Following Minimally Invasive Surgery NCT07500454	ISSSTE Hospital Regional "Gral. Ignacio Zaragoza"	N/A
Unknown	Development of Atılım Kinesiophobia Scale NCT06278012	Atılım University	—
Completed	Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Bunionectomy NCT06215820	Viatris Specialty LLC	Phase 3
Completed	Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy NCT06215859	Viatris Specialty LLC	Phase 3
Completed	Comparison of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block NCT06407037	Diskapi Yildirim Beyazit Education and Research Hospital	N/A
Completed	Assessment of PF614 Effects on Experimental Pain in the Cold Pressure Test (PF614-201) NCT06629402	Ensysce Biosciences	Phase 2
Active Not Recruiting	Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty NCT05100706	University of Toronto	N/A
Unknown	Comparative Effects of Ciprofol and Propofol on Pain Intensity on the First Day After Surgery: a Retrospective NCT06020469	Guangdong Second Provincial General Hospital	—
Completed	Clinical Impact of IPACK Block Addition to Suprainguinal Fascia Iliaca Block NCT06054945	Samsun University	—
Completed	Immediate Analgesic Effects of Cheek Acupuncture for Acute Gouty Arthritis NCT06001112	Guangdong Provincial Hospital of Traditional Chinese Medicine	N/A
Completed	Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy NCT06011746	Tanta University	Phase 4
Unknown	Feasibility Study of Peripheral Venous Cannulation Pain in Predicting Acute Pain After Total Knee Arthroplasty NCT06002724	RenJi Hospital	—
Completed	XG005 for Pain Control in Subjects Undergoing Bunionectomy NCT06017999	Xgene Pharmaceutical Group	Phase 2 / Phase 3
Completed	Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin NCT05929339	Wake Forest University Health Sciences	Phase 2
Recruiting	COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young C NCT06164028	Duke University	—
Completed	Mobilization With Movement in Distal Radial Fractures NCT05976724	Ahi Evran University Education and Research Hospital	N/A
Unknown	Short-Term Effects of Dynamic Taping in Patients With Lumbar Disc Herniation NCT05940519	NAİME ULUG	N/A
Unknown	Effect of Adding TTPB to SAPB in Breast Cancer Surgery NCT06082141	Bezmialem Vakif University	N/A
Recruiting	Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA NCT05754190	Brown University	—
Completed	Comparison of Ketorolac at Three Doses in Children With Acute Pain NCT05641363	Hamilton Health Sciences Corporation	Phase 3
Unknown	Comparison Between Percutaneous Femoral Nerve Neuromodulation Associated With Femoral Nerve Block and Standard NCT05971095	Hospital General Universitario de Valencia	N/A
Unknown	Influence of the Communication Between Nursing Staff and Patients on the Analgesic Response Following Caesarea NCT05970029	University of Haifa	N/A
Completed	Transcutaneous Electrical Nerve Stimulation for Back Pain in the Emergency Department (TENS-ED) NCT05601843	Sam Brophy	N/A
Unknown	Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post-traumatic Acute Pain in the Emergency D NCT05229055	University of Monastir	Phase 2 / Phase 3
Recruiting	Ultrasound Guided TAPB vs Surgical TAPB With Bupivacaine in Cesarean Section NCT05750992	Al-Azhar University	N/A
Completed	Oliceridine in Patients With Acute Burn Injuries NCT05465226	University of Tennessee	Phase 4
Recruiting	Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults NCT05819476	University Hospital, Basel, Switzerland	N/A
Completed	Parasternal Block Combined With Rectus Sheath Block for Cardiac Surgery Under Sternotomy NCT05764616	Campus Bio-Medico University	N/A
Withdrawn	Efficacy and Safety of Tiradentes Association in the Treatment of Acute Pain NCT04593329	EMS	Phase 2
Completed	Remote Immersive Virtual Reality Teaching: NCT05755724	Sunnybrook Health Sciences Centre	N/A
Completed	Preoperative Dexamethasone to Improve Quality of Recovery After Laparoscopic Bariatric Surgery NCT05752734	Ondokuz Mayıs University	—
Unknown	Effectiveness of a Virtual Reality Game for Pediatric Pain and Anxiety Management During Skin Prick Testing NCT05796596	University of Liege	N/A
Unknown	Evaluation of the Analgesic Efficacy of Multimodal Pain Control Regimens That Aim to Limit the Use of Narcotic NCT06095453	Methodist Health System	—
Withdrawn	Efficacy and Safety of Escócia Association in the Treatment of Acute Pain NCT04666701	EMS	Phase 2
Terminated	Acute and Chronic Pain After One-stage Hybrid Arrhythmia Ablation Surgery NCT05211492	Universitair Ziekenhuis Brussel	N/A
Unknown	Premature Enhanced Automated Capture of Comfort Knowledge NCT06037629	Newcastle University	—
Completed	A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adu NCT05721287	Sparian Biosciences, Inc	Phase 1
Enrolling By Invitation	VR-PAT During Home Burn Dressings - Multisite NCT05673551	Nationwide Children's Hospital	N/A
Unknown	Different Local Anesthetic Volumes for TPVB in Post-thoracotomy Analgesia NCT05700357	Ankara City Hospital Bilkent	N/A
Completed	Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions NCT05651360	Oslo University Hospital	—
Completed	Intrathecal Hydromorphone for Postoperative Pain of Anorectal Surgery NCT05579223	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	Phase 2
Completed	Pharmacogenetic-guided Choice of Post-surgery Analgesics NCT05548660	University of Pennsylvania	N/A
Completed	Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty NCT05558410	Vertex Pharmaceuticals Incorporated	Phase 3
Completed	Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy NCT05553366	Vertex Pharmaceuticals Incorporated	Phase 3
Withdrawn	IVs With Buzzy in Chronic Pain Patients NCT05555173	Steward St. Elizabeth's Medical Center of Boston, Inc.	N/A
Unknown	Construction of Perioperative Medical Data Platform and Its Typical Practice to Predict Postoperative Acute Mo NCT05569460	Guangdong Second Provincial General Hospital	—
Completed	Prescribing Vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients with Postoperative Pain: NCT05370404	University of Michigan	N/A
Unknown	Regional Analgesia in Combination With Cryoanalgesia to Prevent Acute Pain Following Nuss Procedure NCT05589246	Pomeranian Medical University Szczecin	N/A
Unknown	Evaluate the Safety and Pharmacokinetic Profile of ETR028 and ETR029 in Healthy Adult Subjects NCT05572190	Elysium Therapeutics, Inc.	Phase 1
Recruiting	Reducing Pain From Wisdom Molar Extractions NCT05335070	Rutgers, The State University of New Jersey	Phase 2
Completed	Machine Learning for Risk Stratification in the Emergency Department (MARS-ED) NCT05497830	Maastricht University Medical Center	N/A
Unknown	Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain NCT05054179	University of British Columbia	Phase 2 / Phase 3
Completed	Subcostal Approach to Anterior Quadratus Block Versus Thoracic Paravertebral Block for Laparoscopic Nephrectom NCT05191966	Ondokuz Mayıs University	N/A
Completed	Comparison of Postoperative Pain With or Without Apical Patency Technique in Asymptomatic Necrotic Teeth NCT05574088	Prime Foundation	N/A
Completed	Evaluation of a New Pain Management Protocol Involving Intranasal Sufentanil in the Emergency Room. NCT05498831	Groupe Hospitalier de la Region de Mulhouse et Sud Alsace	—
Unknown	Efficacy and Safety Study of Ibuprofen Gel Compared to Placebo in the Treatment of Acute Musculoskeletal Pain NCT05013567	Brainfarma Industria Química e Farmacêutica S/A	Phase 3
Completed	Study of PBK_L1704 for the Treatment of Moderate to Severe Acute Pain After Bunionectomy in South Korea NCT05509868	Pharmbio Korea Co., Ltd.	Phase 3
Completed	Pharmacokinetic Study of Paracetamol UNIFLASH (125 MG/1.25 ML) NCT05406752	Unither Pharmaceuticals, France	Phase 1
Unknown	Comparison of the Efficacy of Shotblocker and Acupressure in Reducing Pain Due to Intramuscular Injection NCT05456945	Ataturk University	N/A
Completed	PENG Block Plus Lateral Femoral Cutaneous Nerve Block for Posterolateral-approached Total Hip Arthroplasty NCT05432011	Campus Bio-Medico University	N/A
Completed	Pharmacokinetic Analysis of Bupivacaine in the Presence and Absence of Perineural Dexamethasone in Axillary Bl NCT05359731	University of Chile	Phase 4
Completed	Comparison of the Effects of TFPB and Anterior QLB on Postoperative Analgesia in Cesarean Section Surgery NCT05408403	Ondokuz Mayıs University	N/A
Completed	A Randomized Trial of NSAID Dosing Strategies NCT05239767	Montefiore Medical Center	Phase 4
Unknown	Bi-level vs. Single Level ESB in VATS NCT05294315	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	N/A
Unknown	Femoral Triangle + IPACK Blocks for ACL Reconstruction Analgesia NCT05068063	University of Chile	N/A
Terminated	Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED NCT05422001	University of Aarhus	Phase 4
Completed	Effect of Aromatherapy Massage on Pain and Anxiety After Mastectomy NCT05658367	Istanbul Medipol University Hospital	N/A
Completed	The Effects of Body Mass Index on Thoracic Paravertebral Block Analgesia NCT05357976	Ankara City Hospital Bilkent	N/A
Unknown	Safety and Efficacy Evaluation of S (+) - Ketamine in Children NCT04834427	Chinese PLA General Hospital	Phase 4
Completed	A Phase 1 Dose Escalation Study of Oral VX-708 in Healthy Participants NCT05347394	Vertex Pharmaceuticals Incorporated	Phase 1
Completed	Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain. NCT05317312	Mylan Specialty, LP	Phase 2
Completed	A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of KUR-101 in Healt NCT05114265	Kures, Inc.	Phase 1
Completed	ESPB vs.Combination of ESPB and Superficial PIPB in Cardiac Surgery NCT05191953	Ondokuz Mayıs University	N/A
Unknown	Comparison Erect Spine in Cardiac Surgery NCT04313959	Instituto do Coracao	Phase 3
Completed	REduced Pain After Bariatric Surgery - Sleeve Gastrectomy NCT06383234	Fondazione Policlinico Universitario Campus Bio-Medico	N/A
Completed	REduced Pain After Bariatric Surgery - Gastric Bypass NCT06614257	Fondazione Policlinico Universitario Campus Bio-Medico	N/A
Withdrawn	Ketamine Infusion for Sickle Cell Pain Crisis NCT04005209	Duke University	Phase 4
Completed	Erector Spinae Plane Block in Uniportal VATS NCT04892901	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	—
Completed	Effects of Mirror Therapy Versus Fine Motor Activities on Hand Function in Chronic Stroke Patients. NCT05506826	Riphah International University	N/A
Unknown	Open Label Placebo to Reduce Prescription Opioid Use NCT05014230	Brown University	N/A
Completed	Comparison of the Analgesic Efficacy of Serratus Anterior Plane Block and Intercostal Block NCT05160155	Atatürk Chest Diseases and Chest Surgery Training and Research Hospital	N/A
Unknown	US-Guided SAPB Versus ESPB on Acute and Chronic Pain After VATS NCT05160961	Atatürk Chest Diseases and Chest Surgery Training and Research Hospital	N/A
Completed	Do Vacutainers With Animal Characters Reduce Fear and Anxiety? NCT06345911	Burdur Mehmet Akif Ersoy University	N/A
Completed	Early Postoperative Pain and 30-day Complications Following Major Abdominal Surgery: an Observational Study NCT05244655	Radboud University Medical Center	—
Unknown	Efficacy of Pericapsular Nerve Group Block NCT05154318	The University of Hong Kong	N/A
Completed	Analgesic Effect of Liposomal Bupivacaine NCT05118399	The University of Hong Kong	Phase 4
Completed	A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morp NCT05137184	Oslo University Hospital	Phase 3
Completed	Erector Spinae Plane Block Versus Serratus Anterior Block on Post Mastectomy Pain Syndrome NCT05201963	National Cancer Institute, Egypt	N/A
Withdrawn	Novel Non-opioid Post-surgical Pain Treatment in Females NCT05087914	Northwestern University	Phase 2
Completed	Topical Piroxicam vs Soulagel in the Treatment of Acute Extremity Pain After Emergency Department Discharge NCT05054023	University of Monastir	Phase 2 / Phase 3
Completed	Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery NCT05069311	Udayana University	N/A
Completed	Efficacy of Finger Puppet as a Distraction Method NCT05073497	Biruni University	N/A
Recruiting	Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans NCT05094297	University of Illinois at Chicago	N/A
Unknown	Comparison of Erector Spinae Plane Block and Pectoral Nerve Block for Acute and Chronic Pain in Mastectomies NCT05069805	Hospital de Base	N/A
Completed	Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain NCT05995912	Laboratorios Liomont	Phase 2
Terminated	Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment NCT04716413	Montefiore Medical Center	Phase 4
Completed	A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty NCT05034952	Vertex Pharmaceuticals Incorporated	Phase 2
Completed	PENG Block for Traumatic Hip Fracture in the Emergency Department NCT04997785	Dalin Tzu Chi General Hospital	N/A
Completed	Efficacy and Safety of VVZ-149 Injections in Patients Undergoing Laparoscopic Colectomy NCT05764525	Vivozon Pharmaceutical Inc.	Phase 3
Completed	A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy NCT04977336	Vertex Pharmaceuticals Incorporated	Phase 2
Completed	LI4 Acupuncture for Analgesia in Intrauterine Device Insertion NCT04963582	Nigde Omer Halisdemir University	N/A
Terminated	iPACK Block With Dexamethasone For Total Knee Replacement NCT04917055	University of California, San Diego	Phase 4
Completed	US-Guided Serratus Anterior Plane Block Versus Thoracic Epidural in Patients Undergoing Thoracotomy NCT05672394	National Cancer Institute, Egypt	N/A
Recruiting	Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection NCT04849455	University of California, San Diego	Phase 4
Completed	The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement NCT05023278	University of California, San Francisco	Phase 4
Completed	Acupuncture in the Emergency Department for Pain Management NCT04880733	Case Western Reserve University	N/A
Completed	US-Guided ESPB Versus TPVB on Acute and Chronic Pain After VATS NCT04964401	Atatürk Chest Diseases and Chest Surgery Training and Research Hospital	N/A
Completed	Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a Hig NCT04259645	Anna Uskova	Phase 4
Completed	Paracetamol UNIFLASH for Buccal Use Phase III Trial in Acute Pain Due to a Tooth Extraction NCT04640376	Unither Pharmaceuticals, France	Phase 3
Completed	The Effect of Lidocaine Patch for Postoperative Pain NCT04754451	BON WOOK KOO	Phase 4
Completed	A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial) NCT05966129	Duke University	N/A
Completed	A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center) NCT04445792	Duke University	N/A
Unknown	Pilot Study on the Effects of Low-Level Laser Therapy Treatment for Acute and Persistent Discomfort NCT04774783	Arkansas Colleges of Health Education	N/A
Completed	The Effect of Turkish Music and Comedy Film on Pain, Vital Signs and Cortisol Level in Orthopedic Patients NCT04755114	Inonu University	N/A
Terminated	Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers NCT04251819	University of Alabama at Birmingham	Phase 2 / Phase 3
Unknown	PENG vs Intra-articular Injection for Hip Arthroscopy NCT04698746	Bezmialem Vakif University	N/A
Completed	Telehealth Delivered Physical Rehabilitation for an Ankle Sprain NCT04520854	Kyle Kosik	N/A
Unknown	EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial NCT04879004	Democritus University of Thrace	N/A
Withdrawn	Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery NCT04290442	Bruce Ben-David	Phase 4
Completed	ERECTOR SPINE PLANE BLOCK VERSUS LOCAL INFILTRATION ANAESTHESIA FOR TRANSFORAMINAL PERCUTANEOUS ENDOSCOPIC DIS NCT05483647	Lviv National Medical University	N/A
Completed	Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Reco NCT04250883	Radboud University Medical Center	N/A
Unknown	Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Sp NCT04697498	Lviv National Medical University	N/A
Completed	Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm NCT04671082	Neurana Pharmaceuticals, Inc.	Phase 3
Unknown	Analgesic Efficacy of Dexmedetomidine as Adjuvant to Levobupivacaine in Ultrasound-guided Erector Spinae Plan NCT04732377	South Egypt Cancer Institute	Phase 2 / Phase 3
Completed	BFA Treatment of Pain NCT04464954	Paul Crawford	N/A
Recruiting	Rebooting Infant Pain Assessment: Using Machine Learning to Exponentially Improve Neonatal Intensive Care Unit NCT05579496	York University	—
Completed	Appropriate Opioid Quantities for Acute Pain - Pharmacist Study NCT04484610	Centre for Addiction and Mental Health	Phase 4
Terminated	A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed On NCT04484428	Kowa Research Institute, Inc.	Phase 2
Unknown	Adductor Canal Block in Outpatient Clinic for Pain Control After Knee Arthroplasty NCT04883034	Gadjah Mada University	N/A
Recruiting	Effect of Rectus Sheath Block on Diaphragmatic Function After Elective Upper Abdominal Surgery NCT03725527	Assiut University	N/A
Completed	Comparison of the Effects of QLB 2 and QLB 3 on Post-operative Analgesia in Cesarean Section Surgery NCT04364906	Ondokuz Mayıs University	N/A
Unknown	The Effect of Intravenous Fluid Therapy in Acute Migraine Attacks NCT04287140	Marmara University	N/A
Completed	"Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy" NCT05807945	Paola M Zamora Munoz	Phase 4
Completed	The Effect of Erector Spinae Plane Block on Quality of Recovery and Postoperative Analgesia After Inguinal Her NCT04300153	Başak Altıparmak	N/A
Completed	Ultrasound Percapsular Nerve Group Block VS Fascia Iliaca Block for Hip Fracture NCT04285333	University Tunis El Manar	N/A
Completed	PENG Block Combined to Wound Infiltration for Hip Replacement NCT04306133	Campus Bio-Medico University	N/A
Completed	Parasternal Block for Cardiac Surgery NCT04319588	Campus Bio-Medico University	N/A
Completed	Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction NCT04622735	Unither Pharmaceuticals, France	Phase 3
Completed	Open-label, Crossover, Food Effect Study to Evaluate CT-044 in Healthy Human Volunteers NCT04252833	Lotus Clinical Research, LLC	Phase 1
Unknown	Virtual Reality Use for Peri-Procedural Analgesia and Anxiolysis NCT04218396	University of Calgary	N/A
Completed	Auriculotherapy for Surgical Pain NCT03860259	Jacques E. Chelly	N/A
Withdrawn	A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture NCT02985177	St. Justine's Hospital	Phase 4
Unknown	Mid-point Transverse Process to Pleura Block for Breast Cancer Surgery: A Randomized Controlled Trial NCT03713255	Ottawa Hospital Research Institute	N/A
Recruiting	Magnesium Infusion for Pain Management in Critically Ill Trauma Patients NCT04166877	University of California, Davis	Phase 4
Unknown	Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Vol NCT04175743	Lotus Clinical Research, LLC	Phase 1
Unknown	Analgesic Efficacy of Magnesium Sulphate as an Adjuvant to Levobupivacaine in Erector Spinae Block for Acute P NCT04732390	South Egypt Cancer Institute	Phase 2 / Phase 3
Withdrawn	Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department NCT03436121	Maria Pacella	Phase 2 / Phase 3
Completed	The Effectiveness of Patient-tailored Treatment in Patients With (Sub)Acute Neck Pain NCT04182035	University Ghent	N/A
Completed	Evaluating the Impact of Focused Muscle Contraction Therapy in Retire APF Players NCT04822311	University of Illinois at Chicago	N/A
Completed	Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study NCT04799041	Algenis SpA	Phase 1 / Phase 2
Completed	VR for Burn Dressing Changes at Home NCT04548635	Nationwide Children's Hospital	Phase 2 / Phase 3
Completed	A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing NCT03825549	University of Pennsylvania	N/A
Withdrawn	Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures NCT02957097	Massachusetts General Hospital	Phase 4
Unknown	Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic NCT04013958	Tel-Aviv Sourasky Medical Center	Phase 3
Completed	ANI Versus Standard Care in Surgical Patients Receiving Balanced Sevoflurane-Fentanyl Anesthesia NCT03684590	University of Texas Southwestern Medical Center	N/A
Completed	Physical Therapy Using Virtual Reality/Augmented Reality NCT03874507	Stanford University	N/A
Completed	OMT vs. Standard Therapy in the Management of Acute Neck and Low Back Pain in the Emergency Department NCT06987578	St. Joseph's Regional Medical Center, New Jersey	N/A
Completed	Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery NCT04135157	Ondokuz Mayıs University	N/A
Withdrawn	Improving Children's Cooperation During Dental Injection NCT03978390	University of Alberta	N/A
Completed	Usefulness of Acetaminophen Associated With Strong Opioids for Acute Pain in Cancer Patients NCT04779567	Pontificia Universidad Catolica de Chile	Phase 4
Completed	The Alcohol-Pain Connection: Mechanisms and Genetic/Psychological Correlates NCT03311594	Syracuse University	Phase 1
Completed	Quantity of Opioids for Acute Pain and Limit Unused Medication NCT03953534	Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal	—
Unknown	Does the Understanding of Placebo Mechanisms Compensate for the Loss of Efficacy Associated With Open Label Pl NCT03934138	Laboratoire TIMC-IMAG	N/A
Terminated	Ketamine for Pain in the Emergency Department NCT03896230	Hackensack Meridian Health	Phase 4
Completed	Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression NCT04301895	University of California, San Francisco	Phase 1
Completed	Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl NCT03894800	Oslo University Hospital	Phase 4
Completed	The Effect of Erector Spinae Plane Block Performed Under Direct Vision on Postoperative Pain in Spine Surgery NCT03960528	Bezmialem Vakif University	N/A
Terminated	Out of Plane Approach for Interscalene NCT03785392	The University of Texas Medical Branch, Galveston	N/A
Completed	NSS-Bridge Device for Post-Cesarean Delivery Pain NCT03830307	Grace Lim, MD, MS	N/A
Completed	NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries NCT03834142	Jacques E. Chelly	N/A
Completed	IPACK and Adductor Canal Catheter Patient Outcomes for TKAs? NCT03774966	University of California, Los Angeles	EARLY_Phase 1
Completed	Comparison of Postoperative Outcomes Between Surgeries Anaesthetized With Propofol and Inhalational Anaestheti NCT03875872	The University of Hong Kong	—
Completed	Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures NCT03859635	Indiana University	Phase 3
Completed	Tolperisone in Acute Muscle Spasm of the Back NCT03802565	Neurana Pharmaceuticals, Inc.	Phase 2
Terminated	Benzodiazepines for the Reduction of Distress and Pain During and After Emergency Department Care NCT03756038	Maria Pacella	Phase 2
Completed	Intravenous Lidocaine in Total Knee Replacement NCT03597776	The University of Hong Kong	Phase 4
Unknown	Development and Validation of New "SNU Illustrated Pain Rating Scale" as a Tool for Postoperative Pain Assessm NCT03764046	Seoul National University Hospital	—
Completed	The Relationship Of The Surgical Pleth Index Values With Postoperative Pain Score And Analgesia Consumption NCT05147714	Istanbul University	—
Completed	Virtual Reality Experiences on Acute Pain and Distress NCT03599479	Seoul National University	N/A
Unknown	The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery NCT03761576	Yi Feng, MD	—
Completed	HD-tDCS: Effects on the Somatosensory System NCT04165876	Aalborg University	N/A
Completed	A Dose-ranging Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionect NCT03764072	Vertex Pharmaceuticals Incorporated	Phase 2
Completed	Comparison of Verbal Rating Scale and Numerical Rating Scale in Post Anesthesia Care Unit NCT03768102	Seoul National University Hospital	—
Completed	Breathing Toy for Pain Relief in Pediatric Venipuncture NCT07430514	Koç University	N/A
Completed	IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients NCT03553498	Albert Einstein College of Medicine	Phase 3
Completed	Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain NCT03581123	University of Minnesota	Phase 3
Completed	Intranasal Fentanyl for the Treatment of Acute Severe Pain on the Pediatric Emergency Department of Mercy Hosp NCT03912090	Centre Hospitalier Régional Metz-Thionville	—
Completed	NSS-2 BRIDGE Device in Post-Operative Pain Management NCT03555266	Jacques E. Chelly	N/A
Completed	Sub-dissociative Dose Ketamine Dosing Study NCT03714620	Loyola University	Phase 4
Completed	Virtual Reality for Pain Management in Advanced Heart Failure NCT04572425	Medstar Health Research Institute	N/A
Completed	Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care NCT03537573	University of Pittsburgh	N/A
Active Not Recruiting	Vasopressin and Pain Perception in the Brain NCT03446456	University of Maryland, Baltimore	Phase 1 / Phase 2
Completed	Liposome Bupivacaine Interscalene Total Shoulder NCT03587636	University of Minnesota	Phase 2
Completed	Ketamine Versus Morphine Change Pain Profile NCT03664622	Cairo University	N/A
Completed	Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine NCT03560427	Assiut University	N/A
Active Not Recruiting	The Effect of Light Therapy on Post-Surgical Pain NCT03674697	University of Arizona	N/A
Completed	Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED NCT03521102	Montefiore Medical Center	Phase 2
Completed	Effect of Progressive Relaxation Exercises and TENS on Women Delivering Via Cesarean NCT05511571	Derya Öztürk Özen	N/A
Terminated	Hemidiaphragmatic Paralysis With Diluted Continuous Interscalene Plexus Infusions NCT03592056	Clinica las Condes, Chile	—
Completed	Virtual Reality and Outpatient Hysteroscopy NCT03699280	Imperial College London	N/A
Completed	Effects of Distraction Methods on Pain Perceptions and Anxiety Levels in Children During the Blood Collection NCT04113980	Adiyaman University Research Hospital	N/A
Completed	Effects of Virtual Reality Glasses, Kaleidoscope and Distraction Cards on Pain and Anxiety During Blood Draw i NCT06192498	Burdur Mehmet Akif Ersoy University	N/A
Completed	Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair NCT03587584	University of Minnesota	Phase 4
Completed	Effect of Acupressure on Blood Pressure, Heart Rate and Pain Severity NCT05235841	Kahramanmaras Sutcu Imam University	N/A
Suspended	Medical Mindfulness: Virtual Reality Mindfulness Therapy for Anxiety and Pain Management in Patients With Acut NCT04534101	Stanford University	—
Completed	Pec Infiltration With Liposomal Bupivacaine for Breast Surgery NCT03599635	University of Minnesota	Phase 4
Completed	The Effect of Virtual Reality and Kaleidoscope on Pain and Anxiety Levels During Venipuncture in Children NCT03913897	Adiyaman University Research Hospital	N/A
Completed	Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department NCT03571737	East Carolina University	Phase 3
Completed	Efficacy, Tolerability, Safety, and Pharmacokinetic Study of DFN-15 NCT03554772	Dr. Reddy's Laboratories Limited	Phase 2
Completed	Magnesium Oral Supplementation for Acute Non-specific Low Back Pain NCT04626063	Istanbul University	N/A
Completed	Psychosocial Support for Pre-operative Pain and Distress NCT03665727	University of Utah	N/A
Terminated	Dosing of Ketorolac in the Emergency Department NCT03464461	University of Missouri-Columbia	Phase 4
Completed	A Single Dose Study of SHR0410 in Healthy Male Participants NCT03493191	Atridia Pty Ltd.	Phase 1
Completed	Self-Compassion and Acute Pain NCT03647683	Philipps University Marburg	N/A
Completed	Anaesthesiological Involvement in Postoperative Pain Treatment NCT03496194	Zealand University Hospital	—
Completed	Acute and Persistent Pain in ICU Patients NCT03432546	Tampere University Hospital	—
Completed	A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo NCT03836807	Dompé Farmaceutici S.p.A	Phase 3
Unknown	The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery NCT03847363	Shanghai Zhongshan Hospital	—
Completed	Duloxetine for Acute Post-mastectomy Pain NCT03468348	Assiut University	N/A
Completed	Analgesic Effect of Acupuncture for Patients With Rib Fractures NCT03822273	Chang Gung Memorial Hospital	N/A
Terminated	Opioid Analgesics for Acute Fracture Pain in Adults Discharged From the ED NCT03478423	Mount Sinai Hospital, Canada	N/A
Completed	Effects of Acupressure and Foot Massage on Pain During Heel Lancing in Neonates NCT03906552	Adiyaman University Research Hospital	N/A
Unknown	Analgesic Efficacy of Duloxetine in Patients Undergoing Lumbar Discectomy NCT03549026	Assiut University	N/A
Active Not Recruiting	Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery NCT03408717	KK Women's and Children's Hospital	—
Unknown	Preemptive Analgesic Effects of Popliteal Sciatic Nerve Block in Patients With Bilateral Hallux Valgus Surgery NCT03414593	Asan Medical Center	N/A
Unknown	Analgesic Efficacy of Paravertebral Morphine NCT03379987	Assiut University	N/A
Terminated	RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain NCT03305055	Johns Hopkins University	Phase 4
Completed	Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain NCT03484429	Hunter Holmes Mcguire Veteran Affairs Medical Center	N/A
Completed	Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults NCT03361579	University Hospital, Basel, Switzerland	N/A
Completed	Montefiore Opioid and Pain Study NCT03375645	Montefiore Medical Center	—

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