NCT06466941

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery. The main questions are: 1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia? 2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery? 3. Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?

Detailed description

A patient's psychological profile importantly modulates pain severity, and the overall experience and impact of pain. For instance, catastrophic thinking about pain, including magnification, rumination, and helplessness, is associated with both greater pain severity and impact. Over the years, regional anesthesia has become an integral part of multimodal pain management for many surgeries. Regional anesthesia (epidural and peripheral nerve blocks) to be associated with superior pain control, reduced time to return of bowel function, shorter intraoperative times, fewer side effects and complications, earlier ambulation and functional exercise capacity post-discharge, lower in-hospital mortality, reduced length-of-stay, improved patient satisfaction, and fewer readmissions. The investigators aim to use of validated psychosocial surveys and semi-structured interviews to understand the phenotype of patients who will benefit the most from regional anesthesia. The investigators also aim to understand how different patient phenotypes and regional anesthesia affect perioperative opioid consumption, and development of chronic postsurgical pain.

Conditions

• Acute Pain
• Chronic Post Operative Pain
• Opioid Use

Interventions

Type	Name	Description
PROCEDURE	regional anesthesia	Patients who underwent surgery and received an epidural or peripheral nerve block
PROCEDURE	no regional anesthesia	Patients who underwent surgery and did not received an epidural or peripheral nerve block
OTHER	acute pain consultation	Patients who underwent surgery and had a perioperative (preop, intraop, or postop) acute pain consultation
OTHER	no acute pain consultation	Patients who underwent surgery and did not have a perioperative (preop, intraop, or postop) acute pain consultation

Timeline

• Start date: 2024-07-03
• Primary completion: 2025-12-31
• Completion: 2027-07-01
• First posted: 2024-06-20
• Last updated: 2024-07-15

Locations

1 site across 1 country: United States