NCT06317844

Examination of Psychological and Physiological Pathways Linking Gratitude and Pain

Examination of Psychological and Physiological Pathways Linking Gratitude and Pain and the Moderating Effects of COMT Genotype on These Associations

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 145 (actual)
• Sponsor: Black Hills State University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare the effects of a brief gratitude intervention on individuals' psychological and physiological responses to acute pain. Furthermore, these associations will be examined in the context of genetic variations associated with both pain and psychological processes.

Detailed description

After being informed about the study and potential risks, all patients giving written informed consent will be randomized to a behavioral writing intervention and a cold pressor task. Participants will be randomized to a gratitude or neutral writing condition.

Conditions

• Acute Pain
• Positive Thinking
• Emotions

Interventions

Type	Name	Description
BEHAVIORAL	Behavioral Writing Intervention	This behavioral intervention will require participants to write about certain aspects of their lives.

Timeline

• Start date: 2024-09-10
• Primary completion: 2025-08-19
• Completion: 2025-08-19
• First posted: 2024-03-19
• Last updated: 2026-04-17
• Results posted: 2026-04-17

Locations

1 site across 1 country: United States