NCT06493838

Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Minia University · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

Post dural puncture headache is a distressing issue, many measures tried to treat symptoms but few delt with prevention.

Conditions

• Acute Pain

Interventions

Type	Name	Description
DRUG	intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping.	intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping.
DRUG	Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.	Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.

Timeline

• Start date: 2024-07-15
• Primary completion: 2025-01-15
• Completion: 2025-01-16
• First posted: 2024-07-10
• Last updated: 2024-07-16