NCT03571737

Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department

Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department: A Prospective Randomized Controlled Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: East Carolina University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the addition of a lidocaine patch to ibuprofen in the treatment of acute musculoskeletal pains. Half of the participants will get only ibuprofen for their pain, while other half will receive lidocaine patch plus the ibuprofen. After addition of the pain medications, the participants will be followed for their pain scores and return visits.

Detailed description

Ibuprofen and other nonsteroidal antiinflammatory pain medications have been traditionally used for relief of mild to moderate acute musculoskeletal pains. However, if this medication did not work, a different modality for pain control would be added to the original regimen. In recent times, lidocaine patch has been introduced as a separate modality for pain control. This medication is thought to help by selectively inhibiting voltage-gated sodium channels in nociceptors involved in pain response. Given the separate modality, it would be prudent to see whether the addition of lidocaine patch to the ibuprofen would help relieve the pain more so than the antiinflammatory-only regimen.

Conditions

• Acute Musculoskeletal Disease
• Sprains
• Sprains and Strains
• Injuries
• Emergencies
• Trauma
• Acute Pain

Interventions

Type	Name	Description
DRUG	Ibuprofen	Ibuprofen tablet
DRUG	Lidocaine Patch 4%	Lidocaine patch

Timeline

• Start date: 2018-06-23
• Primary completion: 2020-12-30
• Completion: 2021-01-30
• First posted: 2018-06-28
• Last updated: 2024-03-25
• Results posted: 2024-03-25

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study