Trials / Conditions / Nicotine Dependence

Nicotine Dependence

368 registered clinical trials studyying Nicotine Dependence — 30 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users NCT06909500	Fred Hutchinson Cancer Center	N/A
Not Yet Recruiting	Sex Differences in E-Cigarette Perception NCT07398976	Yale University	N/A
Not Yet Recruiting	Smart Olfaction App to Reduce Relapse NCT07007195	University of Houston	EARLY_Phase 1
Recruiting	Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients NCT07466875	Chiao-Chiao Liao	N/A
Withdrawn	Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomi NCT02974582	National Institute on Minority Health and Health Disparities (NIMHD)	N/A
Not Yet Recruiting	Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) NCT07145866	Massachusetts General Hospital	Phase 4
Recruiting	Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco NCT07250230	Henan Provincial People's Hospital	N/A
Recruiting	A Trial of Varenicline for E-cigarette Cessation NCT07040566	Yale University	Phase 2
Recruiting	Effects of Cannabidiol on Stress and Nicotine Withdrawal NCT07001930	Johns Hopkins University	Phase 1
Recruiting	Behavioral Intervention for Youth to Promote Vaping Cessation NCT06765291	Massachusetts General Hospital	N/A
Completed	Family and Peer Influences on Nicotine Dependence in Medical Students of South Punjab NCT07123389	Nishtar Medical University	—
Recruiting	tDCS Plus Varenicline for Smoking Cessation NCT06798324	Centre for Addiction and Mental Health	Phase 4
Recruiting	E-cigarette Cessation in Adults Who Co-use Cannabis NCT06688539	Medical University of South Carolina	Phase 4
Recruiting	Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches NCT06678789	Medical University of South Carolina	N/A
Recruiting	Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine NCT05962229	University of California, San Francisco	Phase 1
Recruiting	Beta-Adrenergic Modulation of Drug Cue Reactivity NCT05587361	University of Oklahoma	Phase 4
Recruiting	Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures NCT06295757	Masonic Cancer Center, University of Minnesota	N/A
Completed	Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smok NCT07366294	Titin Andri Wihastuti	N/A
Recruiting	NeuroControl of Nicotine Dependence NCT06347055	University of Missouri-Columbia	N/A
Completed	Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening NCT06472869	Massachusetts General Hospital	N/A
Recruiting	Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial NCT06534047	Centre for Addiction and Mental Health	Phase 4
Terminated	Project QUIT+: Adapting and Testing a Smoking Cessation Intervention for Transgender and Gender Expansive Indi NCT06654414	Massachusetts General Hospital	N/A
Recruiting	Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction NCT06077240	Yale University	N/A
Recruiting	Young Adult Tobacco/Nicotine and Cannabis Co-use NCT06239350	Medical University of South Carolina	N/A
Recruiting	Abuse Liability and Appeal of Oral Nicotine Products NCT06506162	University of Southern California	N/A
Completed	A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults NCT05897242	Fred Hutchinson Cancer Center	N/A
Recruiting	Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity. NCT06053567	Jasper A. Smits	Phase 3
Enrolling By Invitation	A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research NCT05852860	Abramson Cancer Center at Penn Medicine	N/A
Unknown	Nicotine and Pavlovian Bias NCT06027723	University of Southern California	EARLY_Phase 1
Unknown	Exercise Training for Smoking Students NCT06291558	Kırklareli University	N/A
Recruiting	Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia NCT05487807	University of Southern California	Phase 1
Completed	Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia NCT06389266	Vanderbilt University Medical Center	N/A
Withdrawn	Vaping High vs. Low Nicotine E-Liquid NCT04047836	University of California, San Francisco	N/A
Completed	Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder NCT05796791	Medical University of South Carolina	EARLY_Phase 1
Completed	Doctors' Perspective on Tobacco Addiction NCT06163872	Karadeniz Technical University	—
Recruiting	Overcoming Nicotine Dependence to Enable Quitting NCT05513872	Rush University Medical Center	Phase 1 / Phase 2
Completed	Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO) NCT06091826	NFL Biosciences SAS	Phase 2
Recruiting	Orexin s Role in the Neurobiology of Substance Use Disorder NCT05630781	National Institute on Drug Abuse (NIDA)	N/A
Recruiting	Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression NCT05660798	National Institute of Cardiology, Warsaw, Poland	N/A
Completed	Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC NCT05658471	University of California, San Francisco	N/A
Completed	Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction NCT05903014	Indonesia University	Phase 4
Recruiting	Smoking Cessation and Menstrual Cycle Phase NCT05515354	Centre for Addiction and Mental Health	Phase 4
Completed	Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2 NCT05473585	Duke University	N/A
Recruiting	IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate NCT05176418	Yale University	EARLY_Phase 1
Withdrawn	Cigarette Harm Reduction With Electronic Cigarette Use NCT03473483	University of California, San Francisco	N/A
Completed	Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency NCT05430334	American University of Beirut Medical Center	N/A
Completed	Improving Tobacco Treatment Rates for Cancer Patients Who Smoke NCT04738643	Abramson Cancer Center at Penn Medicine	N/A
Completed	Varenicline for Nicotine Vaping Cessation in Adolescents NCT05367492	Massachusetts General Hospital	Phase 4
Unknown	Mobile Health for Problematic Behaviors and Substance Use NCT05434429	PredictWatch	N/A
Completed	Nicotine Withdrawal and Reward Processing NCT05041959	University of Oklahoma	N/A
Completed	Effects of Menthol in E-cigarettes on Smoking Behaviors NCT04521647	Yale University	Phase 1
Completed	Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base NCT04170907	Insel Gruppe AG, University Hospital Bern	N/A
Active Not Recruiting	Methadone-Maintained Smokers Switching to E-Cigarettes NCT05206435	Butler Hospital	Phase 4
Active Not Recruiting	Factors Sustaining Tobacco Abstinence in Cancer Patients Treated With Radio-chemotherapy or Radiotherapy NCT06910566	Centre Oscar Lambret	—
Unknown	Using ANDS to Reduce Harm for Low SES Cigarette Smokers NCT05327439	Brown University	N/A
Completed	Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties NCT05095779	University of Oklahoma	Phase 2
Completed	Nicotine Differences in Smokers NCT05159934	Yale University	Phase 1
Completed	Research and Innovation to Stop E-cigarette/Vaping in Young Adults NCT04974580	Ohio State University	Phase 4
Completed	Nicotine's Potential Abuse With Menthol NCT04535362	Yale University	EARLY_Phase 1
Completed	The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence NCT02590393	Duke University	Phase 1 / Phase 2
Completed	Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke NCT04737031	Abramson Cancer Center at Penn Medicine	N/A
Completed	Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy NCT04571216	NFL Biosciences SAS	Phase 2
Completed	Clinical Learning Study for a Mobile Smoking Cessation Program NCT04857515	Click Therapeutics, Inc.	—
Completed	Do Flavors Increase the Addiction Potential of Nicotine? NCT04696380	University of Vermont	Phase 2
Completed	E-cigarette Nicotine Study NCT04709471	University of Vermont	Phase 2
Completed	Testing Financial Incentive Interventions in Dyadic-Smoker Couples NCT04832360	University of Georgia	N/A
Completed	Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH NCT04449510	University of California, San Francisco	N/A
Active Not Recruiting	Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal NCT03968900	University of Alabama at Birmingham	N/A
Terminated	Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents NCT04602494	Massachusetts General Hospital	Phase 4
Completed	Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Stud NCT04646174	Rush University Medical Center	N/A
Completed	Cessation Screening Project NCT04188873	University of Wisconsin, Madison	Phase 4
Completed	The Interaction of Flavor With Nicotine Form in Adult Smokers NCT04262817	Yale University	Phase 1
Completed	THC Crossover Study NCT04429568	University of California, San Francisco	N/A
Completed	Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use NCT04084210	University of Wisconsin, Madison	Phase 2
Completed	QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit A NCT04159571	Wake Forest University Health Sciences	N/A
Unknown	Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation NCT04645914	University Hospital Muenster	N/A
Completed	COVID EHR COHORT at the University of Wisconsin NCT04506528	University of Wisconsin, Madison	—
Completed	Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment NCT04461288	University of California, San Francisco	N/A
Completed	Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco NCT04231539	Roswell Park Cancer Institute	N/A
Recruiting	Optimizing Tobacco Use Treatment for PLWHA NCT04176172	University of Pennsylvania	Phase 3
Completed	Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation NCT03083353	University of Texas at Austin	EARLY_Phase 1
Completed	Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living NCT03904186	Massachusetts General Hospital	N/A
Unknown	Targeting Orexin to Treat Nicotine Dependence NCT03999099	Mclean Hospital	Phase 1
Completed	Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study NCT04043728	Rush University Medical Center	N/A
Completed	Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness NCT04011280	University of California, San Diego	Phase 4
Completed	Accelerated iTBS in Smoking Cessation NCT05271175	Cyprus rTMS Center	N/A
Completed	Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power NCT03839745	University of California, San Francisco	N/A
Completed	Comparing NicoBloc to Nicotine Lozenges NCT03720899	University of Alabama at Birmingham	Phase 2 / Phase 3
Completed	Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol NCT03580525	Yale University	EARLY_Phase 1
Enrolling By Invitation	Healthy People Initiative (HPI) NCT03506867	Ottawa Hospital Research Institute	N/A
Completed	Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods. NCT03700112	Juul Labs, Inc.	N/A
Completed	Text Messaging to Engage and Retain Veterans in Smoking Cessation Counseling NCT03177265	VA Office of Research and Development	N/A
Completed	United States Pre-Market Tobacco Application Pharmacokinetics NCT03719391	Juul Labs, Inc.	N/A
Completed	Enhancing Self Regulation Among Smokers NCT04161144	Medical University of South Carolina	Phase 2
Withdrawn	State and Trait Mediated Response to TMS in Substance Use Disorder NCT03707600	National Institute on Drug Abuse (NIDA)	N/A
Withdrawn	Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment NCT02487953	Duke University	Phase 2
Completed	Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers NCT03593239	Juul Labs, Inc.	N/A
Completed	Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace NCT03272685	University of Minnesota	Phase 3
Completed	Nicotine TMS EFT Smoking Pilot Study NCT03579953	Medical University of South Carolina	EARLY_Phase 1
Completed	The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects NCT03496116	Virginia Commonwealth University	N/A
Completed	Effects of Flavors on Nicotine Reinforcement in Smokers NCT03243630	Yale University	EARLY_Phase 1
Withdrawn	Stage Ib Trial of mSMART With Varenicline NCT03069768	Duke University	Phase 1
Completed	AXS-05 Phase II Trial on Smoking Behavior NCT03471767	James Davis	Phase 2
Terminated	Incentives to Promote Smoking Cessation in Low SES Women NCT03173274	Brown University	N/A
Terminated	Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment NCT03213418	New York State Psychiatric Institute	N/A
Completed	Personalized Dosing of Nicotine Replacement (NRT to Effect) NCT03000387	Centre for Addiction and Mental Health	Phase 4
Terminated	Accelerated rTMS for the Reduction of Nicotine Craving NCT03352609	Medical University of South Carolina	N/A
Completed	Approach Bias Retraining to Augment Smoking Cessation NCT03325777	University of Texas at Austin	N/A
Terminated	Glucocorticoid Antagonist Treatment for Tobacco Use Disorder NCT03248713	Yale University	EARLY_Phase 1
Completed	Brain Stimulation For Cancer Smokers NCT03419741	Medical University of South Carolina	N/A
Completed	Examination of Low Wattage and High Wattage E-Cigarettes NCT03113136	Ohio State University Comprehensive Cancer Center	N/A
Completed	Adaptive Pharmacotherapy for Smoking Cessation NCT02501265	Duke University	Phase 2
Completed	Helping Poor Smokers Quit NCT03194958	Washington University School of Medicine	N/A
Completed	Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2 NCT03168191	Yale University	Phase 1
Unknown	Neural Correlates of Neurofeedback Training NCT03165578	Frank Scharnowski	N/A
Completed	Reducing Tobacco Use Disparities Among Low-Income Adults NCT03077737	Northwestern University	N/A
Completed	YMCA Exercise Intervention for Smoking Cessation Study NCT03080090	University of Texas at Austin	N/A
Completed	Evaluation of a Brief Tobacco Intervention in the US Military NCT03196102	University of Virginia	N/A
Completed	Music to Reduce Use of Smoking in Patients With Schizophrenia NCT03190161	NYU Langone Health	N/A
Completed	New Approaches to Smoking Cessation in Heavy Drinkers NCT02151591	Yale University	Phase 1
Completed	E-cigarettes, Nicotine Inhaler, and Blood Vessel Function NCT03072628	University of California, Los Angeles	N/A
Completed	Nicotine Replacement Therapy in Nicotine-dependent Arrestees NCT02905734	Assistance Publique - Hôpitaux de Paris	Phase 4
Completed	Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers NCT02989038	Duke University	N/A
Unknown	Treating Smokeless Tobacco Use in Rural Veterans NCT02994082	Mark Vander Weg	N/A
Completed	Combination Nicotine Patch / Lorcaserin for Smoking Cessation NCT02906644	Duke University	Phase 2
Completed	Examination of Sleep, Smoking Cessation, and Cardiovascular Health NCT02941718	University of Delaware	Phase 3
Completed	Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers NCT02587312	Brown University	N/A
Withdrawn	Transcranial Direct Current Stimulation in a Smoking Cessation Trial NCT01710410	Centre for Addiction and Mental Health	Phase 2
Completed	Study on Sit to Quit Phone Intervention NCT02840435	Duke University	N/A
Completed	Varenicline (Chantix) Treatment for Waterpipe Smoking Cessation NCT02575183	American University of Beirut Medical Center	Phase 4
Completed	N-acetylcysteine for Tobacco Use Disorder NCT02737358	Medical University of South Carolina	Phase 2
Terminated	Study on Smoking Cessation and Cost Outcomes in the Duke Smoking Cessation Program NCT02845687	Duke University	—
Completed	Testing an Organizational Change Model to Address Smoking in Mental Healthcare NCT02849652	University of Pennsylvania	N/A
Completed	Effects of Intranasal Oxytocin on Cigarette Smoking NCT02595749	University of Southern California	Phase 4
Completed	Adjunctive Mood Management for Telephone-based Smoking Cessation NCT02500589	VA Office of Research and Development	N/A
Completed	Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal NCT02520349	Truth Initiative	—
Completed	Combining Varenicline and Naltrexone for Smoking Cessation NCT02698215	University of California, Los Angeles	Phase 2
Unknown	Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence NCT02635919	Duke University	N/A
Terminated	Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers NCT02599571	Duke University	N/A
Completed	Manipulating Tobacco Constituents in Male Menthol Smokers NCT02592772	UConn Health	N/A
Completed	Babies Living Safe and Smokefree NCT02602288	Temple University	N/A
Completed	Treatment for Nicotine Addiction in Women NCT02448654	Yale University	N/A
Completed	E-Cigarettes: Dynamic Patterns of Use and Health Effects NCT02527980	University of Wisconsin, Madison	—
Completed	Prevention of Nicotine Abstinence in Critically Ill Patients After Major Surgery NCT03847155	University Hospital Ostrava	N/A
Completed	TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence NCT02534454	The Mind Research Network	N/A
Completed	E-cigarettes and Blood Vessel Function NCT02740595	University of California, Los Angeles	N/A
Completed	Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers NCT02378714	Northwestern University	Phase 4
Completed	Clinical Pharmacology of Electronic Cigarettes NCT02470754	University of California, San Francisco	N/A
Terminated	Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement NCT02439944	Centre for Addiction and Mental Health	Phase 2 / Phase 3
Unknown	Smoking Cessation Following Psychiatric Hospitalization NCT02204956	University of Texas at Austin	N/A
Completed	Nicotine Metabolizers and [11C]-(+)-PHNO NCT02514720	Centre for Addiction and Mental Health	N/A
Completed	The Northwest Coalition for Primary Care Practice Support NCT02839382	Kaiser Permanente	N/A
Completed	Stress Neuroadaptation in Tobacco Dependence NCT03262233	University of Wisconsin, Madison	Phase 4
Completed	E-Cigarettes and SNA NCT02724241	University of California, Los Angeles	N/A
Completed	Biomarker Feedback to Motivate Cessation in Pregnancy NCT02431611	Mayo Clinic	Phase 2
Completed	Project 1: Evaluating EHR-Based Health System Modifications for the Chronic Care of Smoking NCT02358330	University of Wisconsin, Madison	—
Completed	Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes NCT02433015	Laureate Institute for Brain Research, Inc.	N/A
Withdrawn	Trial of Computerized SBI to Reduce Teen Alcohol Use NCT01784627	Boston Children's Hospital	Phase 1
Completed	A Trial of E-cigarettes in Current Cigarette Smokers NCT02357173	Medical University of South Carolina	N/A
Completed	Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women NCT02188459	Henry Kranzler	Phase 2
Completed	Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults NCT02498145	Yale University	N/A
Completed	A Quit Smoking Study Using Smartphones NCT02164383	University of Wisconsin, Madison	N/A
Completed	Project 2: Strategies for Reducing Nicotine Content in Cigarettes NCT02139930	Wake Forest University Health Sciences	N/A
Completed	Manipulating Tobacco Constituents in Female Menthol Smokers NCT02048852	UConn Health	N/A
Completed	Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction NCT02401672	Medical University of South Carolina	N/A
Completed	Community Intervention to Reduce Tobacco Use in Pregnant Women NCT02083081	Mayo Clinic	N/A
Completed	The MATCH (Medication Aids for Tobacco Cessation and Health) Study NCT02146911	Centre for Addiction and Mental Health	N/A
Terminated	TMS-fMRI for Neural Pathway in Smokers NCT02665338	Xingbao Li	N/A
Completed	Very Low-Nicotine Cigarettes in Smokers With SUD NCT01989507	Brown University	Phase 2
Completed	EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers NCT02129387	Southern Illinois University Carbondale	—
Withdrawn	Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers NCT02046551	Yale University	Phase 1 / Phase 2
Completed	The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco User NCT02102100	Yale University	N/A
Completed	Electronic Cigarettes in Daily Dependent Smokers NCT02108626	Centre for Addiction and Mental Health	Phase 4
Completed	Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction NCT01876810	Centre for Addiction and Mental Health	Phase 2
Withdrawn	Concurrent PET D2/D3 Receptor Imaging and fMRI Smoking Cue Reactivity in Smokers NCT01784016	Mclean Hospital	Phase 1
Completed	A Study to Help People Quit Smoking. NCT01880099	Yale University	N/A
Completed	Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity NCT01867411	National Institute on Drug Abuse (NIDA)	—
Withdrawn	Trial of Computerized MET for Adolescent Substance Use NCT01784653	Boston Children's Hospital	Phase 1
Completed	Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Fema NCT01926626	Jed E. Rose	Phase 2
Completed	A Mindfulness Based Application for Smoking Cessation NCT01982110	University of Virginia	N/A
Completed	Brain Networks and Addiction Susceptibility NCT01924468	National Institute on Drug Abuse (NIDA)	Phase 1
Unknown	Smoking Cessation for People Living With HIV/AIDS NCT01965405	Wayne State University	N/A
Unknown	Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers NCT01892813	Mark Vander Weg	Phase 3
Completed	Nicotine Withdrawal Symptoms and Smoking Relapse NCT01511614	National Institute on Drug Abuse (NIDA)	N/A
Completed	Vigorous Exercise for Depressed Smokers NCT01860924	Mayo Clinic	N/A
Withdrawn	Tobacco Cessation: Treatment Delivery and Predictors of Outcome NCT01859364	National Institute on Drug Abuse (NIDA)	—
Completed	Wisconsin Tobacco Quit Line Medicaid Incentive Evaluation NCT02713594	University of Wisconsin, Madison	N/A
Unknown	Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System NCT01898169	LA Clinical Trials	N/A
Terminated	D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS) NCT01842334	Mclean Hospital	Phase 1 / Phase 2
Completed	Baclofen Effects in Cigarette Smokers NCT01821560	University of Pennsylvania	Phase 2
Completed	Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers NCT01806779	Duke University	Phase 2
Completed	Extended Varenicline Treatment for Smoking Among Cancer Patients NCT01756885	University of Pennsylvania	Phase 3
Unknown	Electronic Cigarettes and Reactivity to Smoking Cues NCT01782599	Mclean Hospital	N/A
Completed	Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine De NCT01735279	Federal University of São Paulo	Phase 3
Completed	Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers NCT02348385	Yale University	—
Completed	Helping Those With Mental Illness Quit Smoking NCT01783912	University of Wisconsin, Madison	Phase 4
Completed	Smoking, Sex Hormones, and Pregnancy NCT01811225	University of Minnesota	Phase 2
Completed	Smokers' Response to Nicotine Dependence Genotyping NCT01780038	University of Nebraska	N/A
Withdrawn	Progesterone and Atomoxetine for Cocaine Cessation NCT01741376	University of Minnesota	N/A
Completed	Varenicline for Nicotine Dependence Among Those With HIV/AIDS NCT01710137	University of Pennsylvania	Phase 3
Completed	Studying Nicotine Addiction With Transcranial Magnetic Stimulation NCT01702948	National Institute on Drug Abuse (NIDA)	—
Completed	Striving to Quit: First Breath NCT01569490	University of Wisconsin, Madison	N/A
Completed	Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation NCT01685996	Johns Hopkins University	Phase 1 / Phase 2
Withdrawn	Striving to Quit-Wisconsin Tobacco Quit Line NCT01569477	University of Wisconsin, Madison	N/A
Completed	The Effect of Varenicline on D2/D3 Receptor Binding in Smokers NCT01632189	Centre for Addiction and Mental Health	N/A
Completed	Nicotine Replacement for Smoking Cessation During Pregnancy NCT01656733	UConn Health	Phase 4
Completed	Varenicline for Adolescent Smoking Cessation NCT01509547	Medical University of South Carolina	Phase 3
Terminated	Prazosin for Smoking Cessation NCT01642433	Centre for Addiction and Mental Health	Phase 2
Completed	Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months NCT01639079	University of California, San Francisco	N/A
Completed	Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm NCT01699607	Yale University	N/A
Completed	The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking NCT01576874	Kevin Gray, MD	N/A
Completed	Evaluation of Learning-Theory-Based Smoking Cessation Strategies NCT01368653	Rutgers University	N/A
Terminated	Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants NCT01560507	Duke University	Phase 2 / Phase 3
Completed	A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers NCT01553084	University of Wisconsin, Madison	Phase 4
Completed	Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging NCT01664741	Johns Hopkins University	Phase 4
Unknown	Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation NCT01566097	Seoul National University Hospital	N/A
Completed	Kids Safe and Smokefree (KiSS) NCT01745393	Temple University	N/A
Completed	Novel Determinants and Measures of Smokeless Tobacco Use: Study 2 NCT01067599	University of Minnesota	N/A
Withdrawn	Pexacerfont to Reduce Stress-induced Tobacco Craving NCT01557556	National Institute on Drug Abuse (NIDA)	—
Terminated	A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence NCT01480232	A. Eden Evins	Phase 2
Completed	Effects of Varenicline on Smoking Reminders NCT01524627	University of Pennsylvania	Phase 2
Completed	New Treatment for Alcohol and Nicotine Dependence NCT01182766	University of Virginia	Phase 2 / Phase 3
Completed	Developing a Smoking Cessation Intervention for Methadone Maintained Smokers NCT01393392	Rutgers, The State University of New Jersey	Phase 1
Completed	Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources NCT01342523	University of Wisconsin, Madison	Phase 4
Completed	Integrated Treatment for Smoking Cessation & Anxiety in People With HIV NCT01393301	Massachusetts General Hospital	N/A
Completed	Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation NCT01406223	Duke University	Phase 3
Completed	Electronic Decision Support Systems for Smokers With Severe Mental Illness NCT01412866	Dartmouth-Hitchcock Medical Center	N/A
Completed	Study Two on the Effectiveness of Mindfulness Training for Smokers NCT01299909	University of Wisconsin, Madison	N/A
Terminated	Pioglitazone for Heroin and for Nicotine Dependence NCT01395797	New York State Psychiatric Institute	Phase 1 / Phase 2
Completed	Concurrent Bupropion / Varenicline for Smoking Cessation NCT01303861	Duke University	Phase 3
Unknown	Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers NCT01314378	Massachusetts General Hospital	N/A
Completed	A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessati NCT01304810	Nabi Biopharmaceuticals	—
Terminated	Varenicline and Alcohol in Inpatient Addictions Program (IAP) NCT01169610	Mayo Clinic	Phase 3
Completed	Alcohol Counseling for Telephone Quitline Callers NCT01120080	Yale University	Phase 1 / Phase 2
Completed	A Smoking Cessation Treatment for Adult Women NCT01422239	Yale University	Phase 1
Completed	Smoking Cessation for Smokers With Sleep Problems NCT01277887	Yale University	N/A
Completed	Improving the Efficacy of Anti-Nicotine Immunotherapy NCT01280968	Alexey Mukhin	Phase 2
Completed	Progesterone and Brain Imaging Study NCT01954966	University of Pennsylvania	Phase 4
Completed	Nicotinic Modulation of the Default Network of Resting Brain Function NCT01240616	National Institute on Drug Abuse (NIDA)	—
Terminated	Baclofen for Smoking Cessation in a Non-Psychiatric Population NCT01228994	Centre for Addiction and Mental Health	Phase 2
Completed	Testing Counseling Styles to Motivate Smokers to Quit NCT01188018	University of Missouri, Kansas City	Phase 3
Completed	Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse NCT01188967	Massachusetts General Hospital	Phase 2
Unknown	Targeted Intervention for Bipolar Smokers NCT01550029	University of Cincinnati	N/A
Completed	Identifying Optimal Smoking Cessation Intervention Components (Cessation) NCT01116986	University of Wisconsin, Madison	Phase 4
Completed	Identifying Treatments to Motivate Smokers to Quit NCT01122238	University of Wisconsin, Madison	Phase 4
Completed	Evaluation of Treatments to Improve Smoking Cessation Medication Adherence NCT01120704	University of Wisconsin, Madison	Phase 4
Completed	Maintaining Nonsmoking NCT01162239	University of California, San Francisco	Phase 3
Completed	Brain Activity and Smoking Cessation NCT01186055	University of Pennsylvania	—
Completed	Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms NCT01505725	National Institute on Drug Abuse (NIDA)	—
Completed	Trial on the Effectiveness of Mindfulness Training for Smokers NCT01093599	University of Wisconsin, Madison	N/A
Terminated	The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues NCT01411007	Medical University of South Carolina	—
Completed	Smoking-Cessation and Stimulant Treatment (S-CAST) NCT01077024	University of Cincinnati	Phase 3
Completed	Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD) NCT01195597	Universita degli Studi di Catania	N/A
Terminated	Effects of Nicotine on Brain Opioid Receptors NCT01040338	University of Pennsylvania	—
Completed	Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray NCT01136642	National Institute on Drug Abuse (NIDA)	Phase 1
Completed	The Effect of Exercise on Acute Nicotine Withdrawal NCT01047930	University of Pittsburgh	N/A
Completed	Enhancing a High School Based Smoking Cessation Program NCT01145001	Yale University	N/A
Completed	Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder NCT01093937	Centre for Addiction and Mental Health	N/A
Completed	Coping Skills Treatment for Smoking Cessation NCT01061528	Butler Hospital	N/A
Completed	Nicotine Vaccination and Nicotinic Receptor Occupancy NCT00996034	Yale University	Phase 2
Completed	Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependenc NCT01292642	Mclean Hospital	Phase 2
Completed	Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine NCT00956943	University of Pennsylvania	Phase 2
Completed	Medications Development for the Treatment of Cannabis Related Disorders NCT01204723	University of Virginia	Phase 1
Completed	Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality NCT01031433	National Institute on Drug Abuse (NIDA)	—
Completed	Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction NCT01031693	National Institute on Drug Abuse (NIDA)	Phase 1
Completed	Examining a Text Message Intervention for Smoking Cessation NCT01166464	The Miriam Hospital	N/A
Completed	Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers NCT01031121	National Institute on Drug Abuse (NIDA)	—
Completed	Sensitivity to Intravenous Nicotine: Genetic Moderators NCT00969137	Yale University	Phase 1
Completed	Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia NCT01034085	National Institute on Drug Abuse (NIDA)	—
Completed	An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence NCT01047527	University of Pennsylvania	Phase 4
Completed	Transcranial Magnetic Stimulation Effects on Nicotine Craving NCT01690130	Medical University of South Carolina	N/A
Completed	A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers NCT00901459	Duke University	Phase 2
Completed	Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Acti NCT00934024	Medical University of South Carolina	N/A
Completed	Exercise or Relaxation for Smoking Cessation NCT00921388	UConn Health	N/A
Completed	Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes NCT00960778	Medical University of South Carolina	Phase 2
Completed	Mindfulness Training for Smoking Cessation NCT01144689	Yale University	N/A
Completed	Varenicline for the Treatment of Smokeless Tobacco NCT00813917	Mayo Clinic	N/A
Completed	Measuring Smoking Behaviors While Using Varenicline NCT00948155	University of Pennsylvania	Phase 4
Completed	Bupropion for ADHD in Adolescents With Substance Use Disorder NCT00936299	University of Colorado, Denver	Phase 4
Completed	Varenicline and Motivational Advice for Smokers With Substance Use Disorders NCT00756275	Brown University	N/A
Completed	Topiramate to Aid Smoking Cessation in Alcohol Dependent Men NCT00802412	VA Office of Research and Development	Phase 2
Completed	Extinction Based Treatment for Nicotine Dependence NCT00831155	Duke University	Phase 1
Completed	Treatment of Smoking Among Individuals With PTSD NCT00937235	University of Pennsylvania	Phase 2
Completed	Neuropsychological Prognosis Factors of Smoking Cessation NCT01554436	University Hospital, Montpellier	Phase 4
Suspended	Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors NCT01636323	Mclean Hospital	N/A
Completed	A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward NCT00830739	National Institute on Drug Abuse (NIDA)	—
Completed	Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence NCT00749658	University of Minnesota	Phase 2 / Phase 3
Completed	Varenicline for Smoking Cessation in Heavy Drinking Smokers NCT00860028	Yale University	Phase 2
Completed	Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers Wit NCT00770237	University of Maryland, Baltimore	N/A
Suspended	Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Dru NCT01636336	Mclean Hospital	N/A
Withdrawn	Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Ef NCT01589081	Mclean Hospital	N/A
Completed	Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study NCT01943994	Johns Hopkins University	N/A
Completed	Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia NCT00727103	State University of New York - Upstate Medical University	Phase 4
Completed	Pilot Study of Tolcapone in Smokers NCT01202955	University of Pennsylvania	Phase 2
Completed	Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent NCT01148355	National Institute on Drug Abuse (NIDA)	—
Completed	Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms NCT00578669	Butler Hospital	Phase 3
Completed	Human Laboratory Study Of Varenicline in Smokers NCT00709696	University of Minnesota	N/A
Completed	Efficacy of Varenicline in Ambivalent Smokers NCT00595868	University of Vermont Medical Center	Phase 2
Completed	Cue Induced Imaging in Nicotine Dependent Smokers NCT00844701	Medical University of South Carolina	—
Completed	Effects of Varenicline on Cigarette Self Administration NCT00731055	New York State Psychiatric Institute	Phase 2

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