NCT07398976

Sex Differences in E-Cigarette Perception

Sex Differences in E-Cigarette Perception: Study 2

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 44 Years
• Healthy volunteers: Accepted

Summary

This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

Detailed description

The goal of this protocol is to investigate how sex differences in response to menthol and nicotine influence product preference and choice. In this proposal, participants will be exposed to menthol non-nicotine and nicotine containing e-cigarettes and product preference and choice will be examined in a paradigm where a menthol nicotine-containing e-cigarette is progressively more difficult to earn, and a menthol non-nicotine e-cigarette is available at a low, fixed cost. Additionally, it will be investigated how menthol e-cigarettes with and without nicotine impact reward, appeal, and sensory effects in an initial sampling session (secondary and exploratory outcomes).

Conditions

• Nicotine Dependence
• E-cigarette Use

Interventions

Type	Name	Description
OTHER	Nicotine Level 1 (0mg/ml)	Menthol with be paired with 0mg/ml nicotine in an e-cigarette
OTHER	Nicotine Level 2 (36mg/ml)	Menthol with be paired with 36mg/ml nicotine in an e-cigarette
OTHER	Nicotine Level 3 (59mg/ml)	Menthol with be paired with 59mg/ml nicotine in an e-cigarette

Timeline

• Start date: 2026-04-01
• Primary completion: 2027-04-01
• Completion: 2027-04-01
• First posted: 2026-02-10
• Last updated: 2026-02-10

Locations

1 site across 1 country: United States