NCT02989038

Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 182 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 15 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of 15-25 years.

Detailed description

Participants will undergo three sessions in which their reactions to fixed doses of smoke from investigational cigarettes with three different nicotine contents (15.8 mg/gram of tobacco, 2.5 mg/g, and .4 mg/g) will be assessed. Following the third fixed-dose session, participants will return to the lab to choose one of the cigarettes to self-administer.

Conditions

• Nicotine Dependence

Interventions

Type	Name	Description
OTHER	Very Low Nicotine Content Cigarettes	cigarettes with 0.03 nicotine yield with 0.4 mg/g nicotine content and 9.0 mg tar yield
OTHER	Intermediate Nicotine Content Cigarettes	cigarettes with 0.12 nicotine yield with 2.4 mg/g nicotine content and 9.0 mg tar yield
OTHER	Normal Nicotine Content Cigarettes	cigarettes with 0.8 nicotine yield with 15.8 mg/g nicotine content and 10.5 mg tar yield

Timeline

• Start date: 2017-01-01
• Primary completion: 2019-10-22
• Completion: 2019-12-17
• First posted: 2016-12-12
• Last updated: 2020-03-04

Locations

1 site across 1 country: United States