NCT05041959

Nicotine Withdrawal and Reward Processing

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions. The first session will be a screening and training visit to determine final eligibility. Eligible participants will work with a researcher to develop brief scripts about times when they smoke and do other activities. Next, participants will attend two magnetic resonance imaging (MRI) scans - one after abstaining from smoking for 24 hours and the other after smoking as usual. After the second MRI, participants will answer questions on their phone every day for two weeks.

Conditions

• Cigarette Smoking
• Nicotine Dependence
• Nicotine Withdrawal

Interventions

Type	Name	Description
OTHER	Smoking Abstinence	Participants will abstain from smoking for 24 hours
OTHER	Ad Lib Smoking	Participants will continue smoking as usual (i.e. ad lib) in the day leading up to the scan and smoke one cigarette of their own brand immediately prior to scanning.

Timeline

• Start date: 2022-06-02
• Primary completion: 2024-03-29
• Completion: 2024-04-15
• First posted: 2021-09-13
• Last updated: 2024-05-08

Locations

1 site across 1 country: United States