NCT05796791

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for tobacco use disorder when delivered in conjunction with brief motivational enhancement therapy. Participants will receive ketamine assisted motivational enhancement therapy weekly for three weeks and there will be 2 follow up visits. All visits will also consist of questionnaires and saliva samples will be taken. The overall participation will last approximately 8 weeks.

Conditions

• Tobacco Use
• Smoking Cessation
• Nicotine Dependence

Interventions

Type	Name	Description
DRUG	Ketamine Hydrochloride	IM ketamine given in weekly session for a total of 3 weeks
BEHAVIORAL	Motivational enhancement therapy	Brief motivational based therapy

Timeline

• Start date: 2023-05-02
• Primary completion: 2024-06-30
• Completion: 2024-06-30
• First posted: 2023-04-04
• Last updated: 2025-07-18
• Results posted: 2025-07-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study