NCT03072628

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 148 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic nerve activity

Detailed description

Participants will have an acute exposure on 4 occasions1) e-cigarette with nicotine, 2) e-cigarette without nicotine, 3) nicotine inhaler, 4) sham control and undergo ECG recording for heart rate variability, endothelial function measurement using ultrasound ("FMD") and blood tests for oxidative stress markers.

Conditions

• Nicotine Dependence

Interventions

Type	Name	Description
OTHER	e-cig with nicotine	use an e-cig with nicotine for 30 minutes
OTHER	e-cig without nicotine	use an e-cig without nicotine for 30 minutes
OTHER	nicotine inhaler	use a nicotine inhaler for 30 minutes
OTHER	sham control	use an empty e-cigarette for 30 minutes

Timeline

• Start date: 2017-01-11
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2017-03-07
• Last updated: 2023-10-04

Locations

1 site across 1 country: United States