NCT02724241

E-Cigarettes and SNA

The Effects of Electronic Cigarettes on Sympathetic Nerve Activity and Oxidative Stress

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.

Detailed description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.

Conditions

• Nicotine Dependence

Interventions

Type	Name	Description
OTHER	one time exposure to e-cig with nicotine	one time exposure to e-cigarette vapor with nicotine
OTHER	One time exposure to e-cigarette without nicotine	One time exposure to e-cig without nicotine
OTHER	one time exposure to empty e-cigarette	one time exposure to empty e-cigarette (sham control)

Timeline

• Start date: 2015-04-01
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2016-03-31
• Last updated: 2021-12-20

Locations

1 site across 1 country: United States