NCT02740595

E-cigarettes and Blood Vessel Function

The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 148 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.

Detailed description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.

Conditions

• Nicotine Dependence

Interventions

Type	Name	Description
OTHER	one time exposure to e-cig with nicotine	one time exposure to e-cig vapor with nicotine
OTHER	one time exposure to e-cig without nicotine	one time exposure to e-cig without nicotine
OTHER	one time exposure to empty e-cig	one time exposure to empty e-cig (sham control

Timeline

• Start date: 2015-08-01
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2016-04-15
• Last updated: 2023-10-05

Locations

1 site across 1 country: United States