| Not Yet Recruiting | Biologics in Chronic Rhinosinusitis With Nasal Polyposis NCT06824649 | Medical University of South Carolina | Phase 4 |
| Recruiting | Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps NCT07245329 | Tongji Hospital | N/A |
| Recruiting | Complete Remission After Treatment With Biologics for Nasal Polyps NCT07268313 | Rigshospitalet, Denmark | Phase 4 |
| Active Not Recruiting | A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT06639295 | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | Phase 3 |
| Not Yet Recruiting | BIOlogics in Severe Nasal POlyposis SurvEy.: a French Registry NCT06501807 | University Hospital, Lille | N/A |
| Withdrawn | Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhi NCT06461949 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Phase 3 |
| Unknown | Auriculotherapy for Intraoperative Blood Pressure Control NCT06182982 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Anatomo-clinico-biological Profiles in Severe Nasal Polyps NCT06362122 | Poitiers University Hospital | N/A |
| Completed | A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps NCT06036927 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Phase 2 |
| Unknown | Wound Healing After Endoscopic Sinus Surgery NCT06070311 | Assiut University | N/A |
| Active Not Recruiting | Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease NCT05575037 | Brigham and Women's Hospital | Phase 2 |
| Unknown | Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis NCT03607175 | Marina Boruk | Phase 2 / Phase 3 |
| Unknown | A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT05865496 | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | Phase 2 |
| Unknown | Assessment of Oral and Nasal Breathing With Sensors Analyzing Algorithm NCT05869071 | Oulu University Hospital | — |
| Unknown | The Effect of Intraoperative Infusion of Dexmedetomidine Versus Low Dose Ketamine NCT05828199 | Al-Azhar University | Phase 1 |
| Completed | Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP NCT05672030 | Brigham and Women's Hospital | — |
| Recruiting | Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity NCT05094570 | University of Virginia | Phase 4 |
| Unknown | Omalizumab Efficacy in Patients With Refractory Nasal Polyps NCT05405478 | Shiraz University of Medical Sciences | Phase 4 |
| Completed | Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps NCT05274750 | GlaxoSmithKline | Phase 3 |
| Completed | Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps NCT05281523 | GlaxoSmithKline | Phase 3 |
| Completed | RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps. NCT05180357 | AstraZeneca | — |
| Active Not Recruiting | Dupixent Study for Alternate Administration NCT06750471 | Madigan Army Medical Center | Phase 4 |
| Completed | Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS NCT04996576 | Ain Shams University | N/A |
| Recruiting | Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Pat NCT05009758 | Medical University of Vienna | N/A |
| Completed | Role of Doxycycline in Chronic Rhinosinusitis With Nasal Polyps NCT05157412 | Assiut University | Phase 3 |
| Recruiting | Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction? NCT05287841 | Northwell Health | N/A |
| Completed | Efficacy and Safety of Mepolizumab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)/ Eosinophi NCT04607005 | GlaxoSmithKline | Phase 3 |
| Completed | Subcutaneously CM310/Placebo in Patients With Chronic Rhinosinusitis With Nasal Polyposis (CROWNS-1) NCT04805398 | Keymed Biosciences Co.Ltd | Phase 2 |
| Completed | Retrospective Study for Recurrent Nasal Polyposis NCT04804488 | Sohag University | — |
| Unknown | Novel Inflammatory Markers in Different Phenotypes of Severe Asthma NCT04888910 | University of Pisa | — |
| Completed | Preclinical Studies of Omalizumab in Chronic Rhinosinusitis With Nasal Polyposis NCT04583501 | Johns Hopkins University | EARLY_Phase 1 |
| Completed | The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyp NCT04852562 | Zheng Liu | N/A |
| Completed | NAsal Polyps: Inflammatory & Molecular Phenotyping of Responders to Benralizumab NCT04185012 | Humanitas Clinical and Research Center | Phase 3 |
| Terminated | Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps NCT04104594 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Unknown | Impact of Posterior Nasal Neurectomy With Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis With NCT04105361 | Assiut University | N/A |
| Unknown | NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP NCT03963648 | Christian von Buchwald | N/A |
| Unknown | Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Func NCT03965767 | Ain Shams University | Phase 3 |
| Completed | Study of Efficacy of Fevipiprant in Patients With Nasal Polyposis and Asthma NCT03681093 | Novartis Pharmaceuticals | Phase 3 |
| Suspended | Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD) NCT04261582 | National Jewish Health | — |
| Completed | Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative) NCT03704415 | Helsinki University Central Hospital | N/A |
| Unknown | The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nas NCT03943121 | Beijing Tongren Hospital | N/A |
| Completed | Asthma With Nasal Polyposis NCT03694847 | Louis-Philippe Boulet | — |
| Completed | Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 NCT03228914 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | Anterior Ethmoidal Nerve Block in Prevention of Postoperative Agitation NCT03427502 | Lumbini Medical College | N/A |
| Completed | An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps NCT03478930 | Hoffmann-La Roche | Phase 3 |
| Completed | Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban NCT03326063 | Brigham and Women's Hospital | Phase 2 |
| Terminated | Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide NCT03362515 | Thomas Jefferson University | Phase 2 |
| Completed | A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps NCT03280537 | Hoffmann-La Roche | Phase 3 |
| Completed | A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps NCT03280550 | Hoffmann-La Roche | Phase 3 |
| Withdrawn | Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab NCT03369574 | University of Rochester | — |
| Completed | Qualitative Analysis of Subject Experience of Nasal Polyps NCT03221192 | GlaxoSmithKline | — |
| Unknown | Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis NCT03472144 | LifeBridge Health | Phase 3 |
| Completed | Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis NCT03450083 | Johns Hopkins University | Phase 2 |
| Terminated | Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps NCT03102190 | Benjamin Bleier | Phase 1 |
| Completed | Effect of Mepolizumab in Severe Bilateral Nasal Polyps NCT03085797 | GlaxoSmithKline | Phase 3 |
| Unknown | The Activation of Hippo Pathway in Nasal Polyps NCT03151954 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Recruiting | In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps NCT02975310 | Ottawa Hospital Research Institute | N/A |
| Completed | ATP Project (Asthma afTer Polypectomy) NCT02427503 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Anti-Inflammatory Agent in Sinusitis NCT02874144 | Northwestern University | Phase 2 |
| Completed | Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps NCT02855931 | Université de Sherbrooke | N/A |
| Unknown | The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis NCT03374124 | Jianbo Shi | — |
| Active Not Recruiting | Pilot Study of The EPIC Trial NCT02533206 | Ottawa Hospital Research Institute | N/A |
| Completed | Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery NCT02484859 | Recep Tayyip Erdogan University | Phase 4 |
| Terminated | Trial of Verapamil in Chronic Rhinosinusitis NCT02454608 | Benjamin Bleier | N/A |
| Completed | Comparison of Nasal Steroids After FESS in CRSwNP NCT02194062 | Yale University | N/A |
| Withdrawn | Association of Periostin Levels and Chronic Sinusitis NCT02071667 | University of Virginia | — |
| Completed | Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment o NCT02110654 | First Affiliated Hospital, Sun Yat-Sen University | Phase 4 |
| Completed | 12-Month OL Intranasal Fluticasone Propionate BID Using OptiNose Device NCT01623310 | Optinose US Inc. | Phase 3 |
| Completed | An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis NCT01920893 | Sanofi | Phase 2 |
| Terminated | An Open-label Study to Identify Molecular Markers of Steroid Resistance NCT01616160 | Massachusetts General Hospital | Phase 4 |
| Completed | Detection and Use of Nasal Nitrous Oxide and the Electronic Nose NCT02476929 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Completed | Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps NCT01732536 | Intersect ENT | Phase 2 / Phase 3 |
| Completed | The Diagnostics of Extraesophageal Reflux With the Restech System NCT01819454 | University Hospital Ostrava | N/A |
| Unknown | The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis NCT01564849 | Hillel Yaffe Medical Center | — |
| Completed | Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinus NCT01198912 | University Hospital, Ghent | Phase 2 |
| Completed | A Study of the Effectiveness and Safety of Mometasone Furoate Nasal Spray (MFNS, SCH 032088) for the Treatment NCT01386125 | Organon and Co | Phase 3 |
| Completed | The Effect of Preoperative Oral Prednisone on the Operative Field During Nasal Polypectomy. NCT00440219 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Phase 3 |
| Completed | Effects and Safety of Budesonide Inhalation Suspension Via Transnasal Nebulization in Nasal Polyps NCT02024659 | Beijing Tongren Hospital | Phase 2 / Phase 3 |
| Terminated | Treatment of Early Nasal Polyposis With Topical Triamcinolone NCT01222871 | Steward St. Elizabeth's Medical Center of Boston, Inc. | Phase 1 / Phase 2 |
| Completed | Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflam NCT01295866 | Beijing Tongren Hospital | — |
| Completed | Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis NCT01066104 | Massachusetts General Hospital | Phase 2 |
| Completed | Mepolizumab in Nasal Polyposis NCT01362244 | GlaxoSmithKline | Phase 2 |
| Withdrawn | Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study NCT00841802 | Northwestern University | Phase 4 |
| Completed | Biopsies and Polyps NCT00835445 | Laval University | — |
| Completed | Mint Tea for the Treatment of Nasal Polyps NCT00465543 | Hamilton Health Sciences Corporation | Phase 2 |
| Completed | A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery Systems in Nasal Polyps NCT00788463 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |
| Completed | Study of Nasonex® for the Treatment of Nasal Polyps in Pediatric Subjects Between Ages of 6 and Less Than 18 Y NCT00378378 | Organon and Co | Phase 3 |
| Completed | The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNA NCT00739921 | University of California, San Francisco | N/A |
| Completed | Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction NCT02879929 | Central Hospital, Nancy, France | — |
| Completed | Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease NCT00215787 | Head and Neck Surgery Associates | N/A |
| Completed | Medical Polypectomy and Predictors of Response NCT00788749 | University of Dundee | Phase 4 |
| Completed | Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218) NCT00731185 | Organon and Co | Phase 3 |
| Completed | Squamous Cell Carcinoma Antigen Analysis at the University Hospital Ostrava NCT01827423 | University Hospital Ostrava | N/A |