NCT03694847

Asthma With Nasal Polyposis

Comparative Characteristics of Asthmatic Patients With and Without Nasal Polyposis: an Observational, Cross-sectional Study of the Quebec Heart and Lung Institute-Laval University Asthma Database.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,293 (actual)
• Sponsor: Louis-Philippe Boulet · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Asthma is often associated with various comorbidities that may influence its clinical expression. Among those, chronic rhinosinusitis with nasal polyposis (CRSwNP) is observed in 5% of cases. Asthmatic patients with CRSwNP appear to have more severe and poorly controlled asthma, as well as greater bronchial and systemic inflammation, especially those using inhaled corticosteroids as control medication. However, this remains to be validated. In the last decade, there has been interest labeled for phenotyping of asthma and CRSwNP. However, there is scarce data on the phenotype of asthma with CRSwNP. This study aims to describe the phenotype of asthmatic patients with CRSwNP according to the clinical, physiological and inflammatory characteristics and whether there is a more severe phenotype related to the dose of inhaled corticosteroids and the percentage of induced sputum eosinophils.

Detailed description

This study will compare the characteristics of asthmatic patients with CRSwNP with those without CRSwNP.

Conditions

• Asthma
• Nasal Polyps

Timeline

• Start date: 2018-07-19
• Primary completion: 2018-09-15
• Completion: 2018-09-15
• First posted: 2018-10-03
• Last updated: 2018-10-03

Locations

1 site across 1 country: Canada