NCT05672030

Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

Role of Interleukin 5 (IL-5) and IL-5R Signaling in Non-eosinophil Upper Airway Cells in Chronic Rhinosinusitis With Nasal Polyps

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Detailed description

Further characterization of the role of IL-5Rα expression and function on human plasma cells will determine whether inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to plasma cell proliferation. Further characterization of human upper airway epithelial cell IL-5Rα expression and function will determine whether or not inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to epithelial dysfunction. IL-5Rα expression has been identified on several relevant sinus tissue effector cells, including on nasal polyp plasma cells and epithelial cells, and the aim of this study is to further the field by determining the consequences of IL-5 signaling on those cells.

Conditions

• Nasal Polyps
• Aspirin-exacerbated Respiratory Disease

Interventions

Type	Name	Description
OTHER	Non-Interventional	No intervention.

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2023-01-05
• Last updated: 2025-11-24
• Results posted: 2025-11-24

Locations

1 site across 1 country: United States